Tasty and healthy TR(i)Ps. the human quest for culinary pungency

EMBO Reports

Volumn 12, Issue 11, 2011, Pages 1094-1101

  Nilius, Bernd ^a   Appendino, Giovanni ^b  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; CURCUMIN; ESSENTIAL OIL; LEPTIN; OLIVE OIL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4;

ABDOMINAL OBESITY; APPETITE; ARTICLE; BITTER TASTE; CIRCULATION; CURCUMA LONGA; DIET SUPPLEMENTATION; FATTY LIVER; FLAVOR; FOOD COMPOSITION; FOOD INTAKE; FOOD PREFERENCE; FOOD QUALITY; FOOD TEXTURE; GLOSSOPHARYNGEAL NERVE; GUSTATORY SYSTEM; HUMAN; INSULIN RESISTANCE; LICKING; LIPID DIET; NEUROMODULATION; NONHUMAN; ORGANOLEPTIC PROPERTY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SOMATOSENSORY SYSTEM; SWEETNESS; TASTE ACUITY; TASTE BUD; TASTE DISCRIMINATION; THERMOGENESIS; TRIGEMINAL NERVE; WEIGHT REDUCTION;

ANIMALS; BIOLOGICAL EVOLUTION; CAPSAICIN; HEALTH; HUMANS; SIGNAL TRANSDUCTION; SPICES; TASTE; TASTE PERCEPTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 80255141859     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2011.200     Document Type: Article

References (37)

1. Aggarwal BB (2011a) Do dietary spices impair the patient-reported outcomes for stapled hemorrhoidopexy? A randomized controlled study. Surg Endosc 25: 1535-1540
2. Aggarwal BB (2011b) Healing Spices. New York, USA: Sterling
3. Artaria C, Maramaldi G, Appendino G (2011) Sichuan pepper as a "skin" spice. J Appl Cosmetol 29: 87-89
4. Bassoli A, Borgonovo G, Caimi S, Scaglioni L, Morini G, Moriello AS, Marzo VD, Petrocellis LD (2009) Taste-guided identification of high potency TRPA TRPA1 agonists from Perilla frutescens. Bioorg Med Chem 17: 1636-1639
5. Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PAPA (2005) Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 437: 45-46 (Pubitemid 41613421)
6. Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS (2010) The cells and peripheral representation of sodium taste in mice. Nature 464: 297-301
7. Chaudhari N, Roper SD (2010) The cell biology of taste. J Cell Biol 1906: 285-296
8. Chu KM, Ngan MP, Wai MK, Yeung CK, Andrews P PL, Percie du Sert N, Rudd JA (2009) Olvanil: a non-pungent trpv1 activator has anti-emetic properties in the ferret. Neuropharmacology 459: 369-375
9. Cioffi DL (2007) The skinny on TRP V1. Circ Res 100: 934-936
10. Cuomo J, Appendino G, Schneider E, McKinnon T TB, Brown MJ, Togni S, Dixon BM (2001) Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod 74: 664-669
11. Drahl C (2011) Behind olive's bite. www.cen-online.org, 21 March, pp46-47
12. Duke J (2010) Reductionist's rant: principles of spice therapy. J Am Herbalists Guild 9: 60-61
13. Feart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, Scarmeas N, Barberger-Gateau P P (2009) Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA 302: 638-648
14. Galgani JE, Ryan DH, Ravussin E (2010) Effect of capsinoids on energy metabolism in human subjects. Br Nutr J 103: 38-42
15. Garami A, Pakai E, Oliveira DL, Steiner AA AA , Wanner SP, Almeida MC, Lesnikov VA, Gavva NR, Romanovsky AA (2011) Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci 31: 1721-1733
16. Janssen S, Laermans J, Verhulst P-J, Thijs T, Tack J, Depoortere I (2011) Bitter taste receptors and a-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc Natl Acad Sci USA 108: 2094-2099
17. Jordt SE, Julius D (2002) Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 108: 421-430 (Pubitemid 34178405)
18. Kang JH, Tsuyoshi G, Han IS, Kawada T, Kim Y YM, Yu R (2010) Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring) 18: 780-787
19. Kobata K, Todo T, Yazawa S, Iwai K, Watanabe T (1998) Novel capsaicinoid-like substances, capsiate and dihydrocapsiate, from the fruits of a nonpungent cultivar, CH-19 Sweet of pepper (Capsicum annuum L.). J Agric Food Chem 46: 1695-1697 (Pubitemid 128492905)
20. Kobata K, Sutoh K, Todo T, Yazawa S, Iwai K, Watanabe T (1999) Nordihydrocapsiate, a new capsinoid from the fruits of a nonpungent pepper, capsicum annuum. J Nat Prod 62: 335-336 (Pubitemid 29137926)
21. Lang Y, Kisaka H, Sugiyama R, Nomura K, Morita A A, Watanabe T, Tanaka Y, Yazawa S, Miwa T (2009) Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in Capsicum annuum cv. CH-19 Sweet. Plant J 59: 953-961
22. Mattson MP (2008) Dietary factors, hormesis and health. Ageing Res Rev 7: 43-48
23. McGee H (2001) On Food and Cooking: the Science and Lore of the Kitchen. New York, USA: Scribner
24. Milton G (1999) Nathaniel's Nutmeg-How One Man's Courage Changed the Course of History. London, UK: Sceptre
25. Narukawa M, Koizumi K, Iwasaki Y, Kubota K, Watanabe T (2010) Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA TRPA1. Biosci Biotechnol Biochem 74: 1694-1696
26. Ohkawara S, Tanaka-Kagawa T, Furukawa Y, Nishimura T, Jinno H (2010) Activation of the human transient receptor potential vanilloid subtype 1 by essential oils. Biol Pharm Bull 33: 1434-1437
27. Peng J, Li YJ (2010) The vanilloid receptor TRP V1: role in cardiovascular and gastrointestinal protection. Eur Pharmacol J 627: 1-7
28. Peyrot des Gachons C, Uchida K, Bryant B, Shima A A, Sperry JB, Dankulich-Nagrudny L, Tominaga M, Smith AB 3rd, Beauchamp GK, Breslin PAPA (2011) Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. Neurosci J 31: 999-1009
29. Scarmeas N, Luchsinger JA, Schupf N, Brickman A AM, Cosentino S, Tang MX, Stern Y (2009) Physical activity, diet, and risk of Alzheimer disease. JAMA 302: 627-637
30. Sessa WC (2010) A new way to lower blood pressure: pass the chili peppers please! Cell Metab 12: 109-110
31. Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y, Sato H, Takahashi M (2009) Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 89: 45-50
32. Tanaka Y, Munetaka H, Miwa T, Watanabe T, Yazawa S (2010) Newly mutated putative aminotransferase in nonpungent pepper (Capsicum annuum) results in biosynthesis of capsinoids, capsaicinoid analogues. J Agric Food Chem 58: 1761-1767
33. Turner J (2004) Spice: the History of a Temptation. New York, USA: Harper Collins
34. Ursu D, Knopp K, Beattie RE, Liu B, Sher E (2010) Pungency of TRPTRPTRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity. Eur Pharmacol J 641: 114-122
35. Watanabe T, Ohnuki K, Kobata K (2011) Studies on the metabolism and toxicology of emerging capsinoids. Expert Opin Drug Metab Toxicol 7: 533-542
36. Yang D et al (2010) Activation of TRPTRPTRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab 12: 130-141
37. Zhang LL et al (2007) Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ Res 100: 1063-1070 (Pubitemid 46598931)