Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity

European Journal of Pharmacology

Volumn 641, Issue 2-3, 2010, Pages 114-122

  Ursu, Daniel ^a   Knopp, Kelly ^a   Beattie, Ruth E ^a   Liu, Bin ^a   Sher, Emanuele ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Capsaicin; Eye wipe; Kinetics; Lipophilicity; Pungency; TRPV1

Indexed keywords

ARVANIL; CAPSAICIN; OLVANIL; PIPERINE; RESINIFERATOXIN; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR AGONIST;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CHO CELL; CONTROLLED STUDY; DEPOLARIZATION; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG POTENCY; DRUG STRUCTURE; IN VIVO STUDY; LIPOPHILICITY; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ACTION POTENTIALS; ALKALOIDS; ANIMALS; BENZODIOXOLES; CAPSAICIN; DITERPENES; GANGLIA, SPINAL; KINETICS; LIPID METABOLISM; MALE; NEURONS, AFFERENT; PAIN; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POLYUNSATURATED ALKAMIDES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SENSORY RECEPTOR CELLS; SOLUBILITY; TRPV CATION CHANNELS;

EID: 77954084750     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.029     Document Type: Article

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