Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: Re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase

Biochemical Journal

Volumn 367, Issue 1, 2002, Pages 19-30

  Knight, Kirsty ^a   Scrutton, Nigel S ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Calmodulin; Flavoprotein; Transient kinetics

Indexed keywords

ABSORPTION SPECTROSCOPY; FLUORESCENCE; NITROGEN OXIDES; PHOTODIODES;

DISPROPORTIONATION;

ENZYMES;

CALMODULIN; CYTOCHROME P450; CYTOCHROME REDUCTASE; FLAVOPROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; RIBOFLAVIN DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONCENTRATION RESPONSE; ELECTRON TRANSPORT; ENZYME KINETICS; FLOW KINETICS; LIGAND BINDING; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PURIFICATION; RAT; ANIMAL; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; KINETICS; METABOLISM; NERVE CELL; PLASMID; PROTEIN TERTIARY STRUCTURE; SPECTROFLUOROMETRY; SPECTROPHOTOMETRY; TIME;

ANIMALS; CALMODULIN; CATALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; FLAVINS; FLAVOPROTEINS; KINETICS; MODELS, CHEMICAL; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; NEURONS; NITRIC OXIDE SYNTHASE; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; RATS; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY; TIME FACTORS;

EID: 0036797554     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020667     Document Type: Article

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