Bioartificial liver devices: Perspectives on the state of the art

Frontiers of Medicine in China

Volumn 5, Issue 1, 2011, Pages 15-19

  Ding, Yi Tao ^a   Shi, Xiao Lei ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Acute liver failure; Bioartificial livers; Bioreactor; Hepatocyte

Indexed keywords

ACUTE LIVER FAILURE; ARTIFICIAL LIVER; BIOREACTOR; EQUIPMENT DESIGN; HUMAN; LIVER CELL; PHYSIOLOGY; REVIEW; STANDARD;

BIOREACTORS; EQUIPMENT DESIGN; HEPATOCYTES; HUMANS; LIVER FAILURE, ACUTE; LIVER, ARTIFICIAL;

EID: 80055074554     PISSN: 16737342     EISSN: 16737458     Source Type: Journal    
DOI: 10.1007/s11684-010-0110-x     Document Type: Review

References (43)

1. Pathikonda M, Munoz S J. Acute liver failure. Ann Hepatol, 2010, 9(1): 7-14
2. Gerlach J C, Zeilinger K, Patzer Ii J F. Bioartificial liver systems: why, what, whither? Regen Med, 2008, 3(4): 575-595
3. Chamuleau R A, Deurholt T, Hoekstra R. Which are the right cells to be used in a bioartificial liver? Metab Brain Dis, 2005, 20(4): 327-335
4. Poyck P P, Hoekstra R, van Wijk A C, Attanasio C, Calise F, Chamuleau R A, van Gulik T M. Functional and morphological comparison of three primary liver cell types cultured in the AMC bioartificial liver. Liver Transpl, 2007, 13(4): 589-598
5. Sauer I M, Zeilinger K, Obermayer N, Pless G, Grünwald A, Pascher A, Mieder T, Roth S, Goetz M, Kardassis D, Mas A, Neuhaus P, Gerlach J C. Primary human liver cells as source for modular extracorporeal liver support-a preliminary report. Int J Artif Organs, 2002, 25(10): 1001-1005
6. Wang H H, Wang Y J, Liu H L, Liu J, Huang Y P, Guo H T, Wang Y M. Detection of PERV by polymerase chain reaction and its safety in bioartificial liver support system. World J Gastroenterol, 2006, 12(8): 1287-1291
7. Hoekstra R, Chamuleau R A. Recent developments on human cell lines for the bioartificial liver. Int J Artif Organs, 2002, 25(3): 182-191
8. Kobayashi N, Okitsu T, Nakaji S, Tanaka N. Hybrid bioartificial liver: establishing a reversibly immortalized human hepatocyte line and developing a bioartificial liver for practical use. J Artif Organs, 2003, 6(4): 236-244
9. Fonsato V, Herrera M B, Buttiglieri S, Gatti S, Camussi G, Tetta C. Use of a rotary bioartificial liver in the differentiation of human liver stem cells. Tissue Eng Part C Methods, 2010, 16(1): 123-132
10. Sharma R, Greenhough S, Medine C N, Hay D C. Threedimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver construction. J Biomed Biotechnol, 2010, doi:10.1155/2010/236147
11. Kobayashi N, Westerman K A, Tanaka N, Fox I J, Leboulch P. A reversibly immortalized human hepatocyte cell line as a source of hepatocyte-based biological support. Addict Biol, 2001, 6(4): 293-300
12. Watanabe T, Shibata N, Westerman K A, Okitsu T, Allain J E, Sakaguchi M, Totsugawa T, Maruyama M, Matsumura T, Noguchi H, Yamamoto S, Hikida M, Ohmori A, Reth M, Weber A, Tanaka N, Leboulch P, Kobayashi N. Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers. Transplantation, 2003, 75(11): 1873-1880
13. Totsugawa T, Yong C, Rivas-Carrillo J D, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Westerman K A, Kohara M, Reth M, Tanaka N, Leboulch P, Kobayashi N. Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination. J Hepatol, 2007, 47(1): 74-82
14. Enosawa S, Miyashita T, Saito T, Omasa T, Matsumura T. The significant improvement of survival times and pathological parameters by bioartificial liver with recombinant HepG2 in porcine liver failure model. Cell Transplant, 2006, 15(10): 873-880
15. Thomas R J, Bennett A, Thomson B, Shakesheff K M. Hepatic stellate cells on poly(DL-lactic acid) surfaces control the formation of 3D hepatocyte co-culture aggregates in vitro. Eur Cell Mater, 2006, 11: 16-26, discussion 26
16. Nedredal G I, Elvevold K, Ytrebø L M, Fuskevåg O M, Pettersen I, Bertheussen K, Langbakk B, Smedsrød B, Revhaug A. Significant contribution of liver nonparenchymal cells to metabolism of ammonia and lactate and cocultivation augments the functions of a bioartificial liver. Am J Physiol Gastrointest Liver Physiol, 2007, 293(1): G75-G83
17. Gu J, Shi X, Zhang Y, Ding Y. Heterotypic interactions in the preservation of morphology and functionality of porcine hepatocytes by bone marrow mesenchymal stem cells in vitro. J Cell Physiol, 2009, 219(1): 100-108
18. Gu J, Shi X, Chu X, Zhang Y, Ding Y. Contribution of bone marrow mesenchymal stem cells to porcine hepatocyte culture in vitro. Biochem Cell Biol, 2009, 87(4): 595-604
19. Gu J, Shi X, Zhang Y, Chu X, Hang H, Ding Y. Establishment of a three-dimensional co-culture system by porcine hepatocytes and bone marrow mesenchymal stem cells in vitro. Hepatol Res, 2009, 39(4): 398-407
20. Allen J W, Hassanein T, Bhatia S N. Advances in bioartificial liver devices. Hepatology, 2001, 34(3): 447-455
21. Park J K, Lee D H. Bioartificial liver systems: current status and future perspective. J Biosci Bioeng, 2005, 99(4): 311-319
22. Park J, Li Y, Berthiaume F, Toner M, Yarmush M L, Tilles A W. Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates. Biotechnol Bioeng, 2008, 99(2): 455-467
23. Kinasiewicz A, Smietanka A, Gajkowska B, Werynski A. Impact of oxygenation of bioartificial liver using perfluorocarbon emulsion perftoran on metabolism of human hepatoma C3A cells. Artif Cells Blood Substit Immobil Biotechnol, 2008, 36(6): 525-534
24. Sauer I M, Kardassis D, Zeillinger K, Pascher A, Gruenwald A, Pless G, Irgang M, Kraemer M, Puhl G, Frank J, Müller A R, Steinmüller T, Denner J, Neuhaus P, Gerlach J C. Clinical extracorporeal hybrid liver support-phase I study with primary porcine liver cells. Xenotransplantation, 2003, 10(5): 460-469
25. Poyck P P, Mareels G, Hoekstra R, vanWijk A C, van der Hoeven T V, van Gulik T M, Verdonck P R, Chamuleau R A. Enhanced oxygen availability improves liver-specific functions of the AMC bioartificial liver. Artif Organs, 2008, 32(2): 116-126
26. De Bartolo L, Jarosch-Von Schweder G, Haverich A, Bader A. A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: cell viability and tissue-specific functions. Biotechnol Prog, 2000, 16(1): 102-108
27. Sullivan J P, Gordon J E, Palmer A F. Simulation of oxygen carrier mediated oxygen transport to C3A hepatoma cells housed within a hollow fiber bioreactor. Biotechnol Bioeng, 2006, 93(2): 306-317
28. Sullivan J P, Gordon J E, Bou-Akl T, Matthew H W, Palmer A F. Enhanced oxygen delivery to primary hepatocytes within a hollow fiber bioreactor facilitated via hemoglobin-based oxygen carriers. Artif Cells Blood Substit Immobil Biotechnol, 2007, 35(6): 585-606
29. Sullivan J P, Harris D R, Palmer A F. Convection and hemoglobinbased oxygen carrier enhanced oxygen transport in a hepatic hollow fiber bioreactor. Artif Cells Blood Substit Immobil Biotechnol, 2008, 36(4): 386-402
30. Chu X H, Shi X L, Feng Z Q, Gu Z Z, Ding Y T. Chitosan nanofiber scaffold enhances hepatocyte adhesion and function. Biotechnol Lett, 2009, 31(3): 347-352
31. Feng Z Q, Chu X, Huang N P, Wang T, Wang Y, Shi X, Ding Y, Gu Z Z. The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function. Biomaterials, 2009, 30(14): 2753-2763
32. Chu X H, Shi X L, Feng Z Q, Gu J Y, Xu H Y, Zhang Y, Gu Z Z, Ding Y T. In vitro evaluation of a multi-layer radial-flow bioreactor based on galactosylated chitosan nanofiber scaffolds. Biomaterials, 2009, 30(27): 4533-4538
33. Park J, Berthiaume F, Toner M, Yarmush M L, Tilles A W. Microfabricated grooved substrates as platforms for bioartificial liver reactors. Biotechnol Bioeng, 2005, 90(5): 632-644
34. Park J, Berthiaume F, Toner M, Yarmush M L, Tilles A W. Microfabricated grooved substrates as platforms for bioartificial liver reactors. Biotechnol Bioeng, 2005, 90(5): 632-644
35. Hochleitner B, Hengster P, Bucher H, Ladurner R, Schneeberger S, Krismer A, Kleinsasser A, Barnas U, Klima G, Margreiter R. Significant survival prolongation in pigs with fulminant hepatic failure treated with a novel microgravity-based bioartificial liver. Artif Organs, 2006, 30(12): 906-914
36. Hochleitner B, Hengster P, Duo L, Bucher H, Klima G, Margreiter R. A novel bioartificial liver with culture of porcine hepatocyte aggregates under simulated microgravity. Artif Organs, 2005, 29(1): 58-66
37. Shinohara H, Shimada M, Ikemoto T, Morine Y, Imura S, Fujii M, Imaizumi T, Murayama M, Aiba Y. New type of artificial liver support system (ALSS) using the photocatalytic effect of titanium oxide. Dig Dis Sci, 2007, 52(9): 2271-2275
38. Sussman N L, Gislason G T, Conlin C A, Kelly J H. The Hepatix extracorporeal liver assist device: initial clinical experience. Artif Organs, 1994, 18(5): 390-396
39. Watanabe F D, Mullon C J, Hewitt W R, Arkadopoulos N, Kahaku E, Eguchi S, Khalili T, Arnaout W, Shackleton C R, Rozga J, Solomon B, Demetriou A A. Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial. Ann Surg, 1997, 225(5): 484-491, discussion 491-494
40. Patzer J F, Mazariegos G V, Lopez R. Preclinical evaluation of the Excorp Medical, Inc., bioartifical liver support system. Am Coll Surg, 2002, 195: 299-310
41. Morsiani E, Pazzi P, Puviani A C, Brogli M, Valieri L, Gorini P, Scoletta P, Marangoni E, Ragazzi R, Azzena G, Frazzoli E, Di Luca D, Cassai E, Lombardi G, Cavallari A, Faenza S, Pasetto A, Girardis M, Jovine E, Pinna A D. Early experiences with a porcine hepatocyte-based bioartificial liver in acute hepatic failure patients. Int J Artif Organs, 2002, 25(3): 192-202
42. Ding Y T, Qiu Y D, Chen Z, Xu Q X, Zhang H Y, Tang Q, Yu D C. The development of a new bioartificial liver and its application in 12 acute liver failure patients. World J Gastroenterol, 2003, 9(4): 829-832
43. Xu Q, Yu D, Qiu Y, Zhang H, Ding Y. Function of a new internal bioartificial liver: an in vitro study. Ann Clin Lab Sci, 2003, 33(3): 306-312