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Volumn 93, Issue 2, 2006, Pages 306-317

Simulation of oxygen carrier mediated oxygen transport to C3A hepatoma cells housed within a hollow fiber bioreactor

Author keywords

BLAD; Hepatocyte; Hepatoma; Hollow fiber bioreactor; Model; Oxygen carrier; Oxygen delivery; Oxygen transport; Red blood cell; Simulation

Indexed keywords

ARTIFICIAL ORGANS; BIOMEDICAL ENGINEERING; BLOOD; CELLS; COMPUTER SIMULATION; DISSOLUTION; FINITE ELEMENT METHOD; OXYGEN;

EID: 33645559217     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.20673     Document Type: Article
Times cited : (30)

References (75)
  • 1
    • 0001314221 scopus 로고
    • The hemoglobin system. VI. The oxygen dissociation curve of hemoglobin
    • Adair GS. 1925. The hemoglobin system. VI. The oxygen dissociation curve of hemoglobin. J Biol Chem 63:529-545.
    • (1925) J Biol Chem , vol.63 , pp. 529-545
    • Adair, G.S.1
  • 2
    • 0036772334 scopus 로고    scopus 로고
    • Engineering liver therapies for the future
    • Allen JW, Bhatia SN. 2002. Engineering liver therapies for the future. Tissue Eng 8(5):725-737.
    • (2002) Tissue Eng , vol.8 , Issue.5 , pp. 725-737
    • Allen, J.W.1    Bhatia, S.N.2
  • 3
    • 0037420747 scopus 로고    scopus 로고
    • Formation of steady-state oxygen gradients in vitro-Application to liver zonation
    • Allen JW, Bhatia SN. 2003. Formation of steady-state oxygen gradients in vitro-Application to liver zonation. Biotechnol Bioeng 82(3):253-262.
    • (2003) Biotechnol Bioeng , vol.82 , Issue.3 , pp. 253-262
    • Allen, J.W.1    Bhatia, S.N.2
  • 4
    • 0034861615 scopus 로고    scopus 로고
    • Advances in bioartificial liver devices
    • Allen JW, Hassanein T, Bhatia SN. 2001. Advances in bioartificial liver devices. Hepatology 34(3):447-455.
    • (2001) Hepatology , vol.34 , Issue.3 , pp. 447-455
    • Allen, J.W.1    Hassanein, T.2    Bhatia, S.N.3
  • 5
    • 0347413685 scopus 로고    scopus 로고
    • Determination of size distribution and encapsulation efficiency of liposome-encapsulated hemoglobin blood substitutes using asymmetric flow field-flow fractionation coupled with multi-angle static light scattering
    • Arifin DR, Palmer AF. 2003. Determination of size distribution and encapsulation efficiency of liposome-encapsulated hemoglobin blood substitutes using asymmetric flow field-flow fractionation coupled with multi-angle static light scattering. Biotechnol Progr 19(6):1798-1811.
    • (2003) Biotechnol Progr , vol.19 , Issue.6 , pp. 1798-1811
    • Arifin, D.R.1    Palmer, A.F.2
  • 6
    • 22944465780 scopus 로고    scopus 로고
    • Polymersome encapsulated hemoglobin: A novel type of oxygen carrier
    • Arifin D, Palmer A. 2005a. Polymersome encapsulated hemoglobin: A novel type of oxygen carrier. Biomacromolecules 6(4):2172-2181.
    • (2005) Biomacromolecules , vol.6 , Issue.4 , pp. 2172-2181
    • Arifin, D.1    Palmer, A.2
  • 7
    • 20044381699 scopus 로고    scopus 로고
    • Physical properties and stability mechanisms of poly(ethylene glycol) conjugated liposome encapsulaed hemoglobin dispersions
    • Arifin DR, Palmer AF. 2005b. Physical properties and stability mechanisms of poly(ethylene glycol) conjugated liposome encapsulaed hemoglobin dispersions. Artif Cells Blood Substit Biotechnol 33:137-162.
    • (2005) Artif Cells Blood Substit Biotechnol , vol.33 , pp. 137-162
    • Arifin, D.R.1    Palmer, A.F.2
  • 8
    • 20044375019 scopus 로고    scopus 로고
    • Stability of liposome encapsulated hemoglobin dispersions
    • Arifin DR, Palmer AF. 2005c. Stability of liposome encapsulated hemoglobin dispersions. Artif Cells Blood Substit Biotechnol 33(2):113-136.
    • (2005) Artif Cells Blood Substit Biotechnol , vol.33 , Issue.2 , pp. 113-136
    • Arifin, D.R.1    Palmer, A.F.2
  • 9
    • 0028968239 scopus 로고
    • Critical limitations in biological production of chemicals - Process or genetic solutions
    • Bailey JE. 1995. Critical limitations in biological production of chemicals-Process or genetic solutions. FEMS Microbiol Rev 16(2-3):271-276.
    • (1995) FEMS Microbiol Rev , vol.16 , Issue.2-3 , pp. 271-276
    • Bailey, J.E.1
  • 11
    • 0014989611 scopus 로고
    • Prediction of blood flow in tubes with diameters as small as 29 micron
    • Barbee AR, Cokelet GR. 1971b. Prediction of blood flow in tubes with diameters as small as 29 micron. Microvasc Res 3:17-21.
    • (1971) Microvasc Res , vol.3 , pp. 17-21
    • Barbee, A.R.1    Cokelet, G.R.2
  • 12
    • 0023258224 scopus 로고
    • Human-hemoglobin cross-linked through the polyphosphate-binding site - Functional-properties and evidence for conformers
    • Bellelli A, Brunori M, Condo SG, Giardina B. 1987. Human-hemoglobin cross-linked through the polyphosphate-binding site-Functional-properties and evidence for conformers. J Biol Chem 262(6):2624-2629.
    • (1987) J Biol Chem , vol.262 , Issue.6 , pp. 2624-2629
    • Bellelli, A.1    Brunori, M.2    Condo, S.G.3    Giardina, B.4
  • 14
    • 0017767070 scopus 로고
    • A comparison of two nonclassical models for oxygen consumption in brain and liver tissue
    • Buerk DG, Saidel GM. 1978. A comparison of two nonclassical models for oxygen consumption in brain and liver tissue. Adv Exp Med Biol 94:225-232.
    • (1978) Adv Exp Med Biol , vol.94 , pp. 225-232
    • Buerk, D.G.1    Saidel, G.M.2
  • 17
    • 0026535070 scopus 로고
    • Protein solvation in allosteric regulation - A water effect on hemoglobin
    • Colombo MF, Rau DC, Parsegian VA. 1992. Protein solvation in allosteric regulation-A water effect on hemoglobin. Science 256(5057):655-659.
    • (1992) Science , vol.256 , Issue.5057 , pp. 655-659
    • Colombo, M.F.1    Rau, D.C.2    Parsegian, V.A.3
  • 19
    • 0001412165 scopus 로고
    • One-at-a-time-plans
    • Daniel C. 1973. One-at-a-time-plans. J Am Stat Assoc 68:353-360.
    • (1973) J Am Stat Assoc , vol.68 , pp. 353-360
    • Daniel, C.1
  • 20
    • 0033586944 scopus 로고    scopus 로고
    • Predictive control of hollow-fiber bioreactors for the production of monoclonal antibodies
    • Dowd JE, Weber I, Rodriguez B, Piret JM, Kwok KE. 1999. Predictive control of hollow-fiber bioreactors for the production of monoclonal antibodies. Biotechnol Bioeng 63(4):484-492.
    • (1999) Biotechnol Bioeng , vol.63 , Issue.4 , pp. 484-492
    • Dowd, J.E.1    Weber, I.2    Rodriguez, B.3    Piret, J.M.4    Kwok, K.E.5
  • 21
    • 5444226407 scopus 로고    scopus 로고
    • + on the oxygen binding properties of glutaraldehyde-polymerized bovine hemoglobin-based blood substitutes
    • + on the oxygen binding properties of glutaraldehyde-polymerized bovine hemoglobin-based blood substitutes. Biotechnol Progr 20(5):1543-1549.
    • (2004) Biotechnol Progr , vol.20 , Issue.5 , pp. 1543-1549
    • Eike, J.H.1    Palmer, A.F.2
  • 22
    • 4043084061 scopus 로고    scopus 로고
    • Effect of glutaraldehyde concentration on the physical properties of polymerized hemoglobin-based oxygen carriers
    • Eike JH, Palmer AF. 2004b. Effect of glutaraldehyde concentration on the physical properties of polymerized hemoglobin-based oxygen carriers. Biotechnol Progr 20(4):1225-1232.
    • (2004) Biotechnol Progr , vol.20 , Issue.4 , pp. 1225-1232
    • Eike, J.H.1    Palmer, A.F.2
  • 23
    • 2942700266 scopus 로고    scopus 로고
    • 4 concentration and reaction time on physical properties of glutaraldehyde-polymerized hemoglobin
    • 4 concentration and reaction time on physical properties of glutaraldehyde-polymerized hemoglobin. Biotechnol Progr 20(3):946-952.
    • (2004) Biotechnol Progr , vol.20 , Issue.3 , pp. 946-952
    • Eike, J.H.1    Palmer, A.F.2
  • 24
    • 2942722660 scopus 로고    scopus 로고
    • Oxidized mono-, di-, tri-, and polysaccharides as potential hemoglobin cross-linking reagents for the synthesis of high oxygen affinity artificial blood substitutes
    • Eike JH, Palmer AF. 2004d. Oxidized mono-, di-, tri-, and polysaccharides as potential hemoglobin cross-linking reagents for the synthesis of high oxygen affinity artificial blood substitutes. Biotechnol Progr 20(3):953-962.
    • (2004) Biotechnol Progr , vol.20 , Issue.3 , pp. 953-962
    • Eike, J.H.1    Palmer, A.F.2
  • 25
    • 0022450093 scopus 로고
    • A theoretical-analysis of the effect of the particulate nature of blood on oxygen release in capillaries
    • Federspiel WJ, Popel AS. 1986. A theoretical-analysis of the effect of the particulate nature of blood on oxygen release in capillaries. Microvasc Res 32(2):164-189.
    • (1986) Microvasc Res , vol.32 , Issue.2 , pp. 164-189
    • Federspiel, W.J.1    Popel, A.S.2
  • 28
    • 0028027456 scopus 로고
    • A device to measure the oxygen-uptake rate of attached cells-Importance in bioartificial organ design
    • Foy BD, Rotem A, Toner M, Tompkins RG, Yarmush ML. 1994. A device to measure the oxygen-uptake rate of attached cells-Importance in bioartificial organ design. Cell Transplant 3(6):515-527.
    • (1994) Cell Transplant , vol.3 , Issue.6 , pp. 515-527
    • Foy, B.D.1    Rotem, A.2    Toner, M.3    Tompkins, R.G.4    Yarmush, M.L.5
  • 30
    • 0019195078 scopus 로고
    • Flow of blood through narrow capillaries-Rheological mechanisms determining capillary hematocrit and apparent viscosity
    • Gaehtgens P. 1980. Flow of blood through narrow capillaries-Rheological mechanisms determining capillary hematocrit and apparent viscosity. Biorheology 17(1-2):183-189.
    • (1980) Biorheology , vol.17 , Issue.1-2 , pp. 183-189
    • Gaehtgens, P.1
  • 31
    • 0026766117 scopus 로고
    • Metabolic zonation of the liver - Regulation and implications for liver-function
    • Gebhardt R. 1992. Metabolic zonation of the liver-Regulation and implications for liver-function. Pharmacol Ther 53(3):275-354.
    • (1992) Pharmacol Ther , vol.53 , Issue.3 , pp. 275-354
    • Gebhardt, R.1
  • 32
    • 0014939904 scopus 로고
    • The reaction of oxygen with hemoglobin and the kinetic basis of the effect of salt on binding of oxygen
    • Gibson Q. 1970. The reaction of oxygen with hemoglobin and the kinetic basis of the effect of salt on binding of oxygen. J Biol Chem 245(13):3285-3288.
    • (1970) J Biol Chem , vol.245 , Issue.13 , pp. 3285-3288
    • Gibson, Q.1
  • 33
    • 23944449695 scopus 로고    scopus 로고
    • Impact of increased oxygen delivery via bovine red blood cell supplementation of culturing media on select metabolic and synthetic functions of C3A hepatocytes maintained within a hollow fiber bioreactor
    • Gordon J, Palmer A. 2005. Impact of increased oxygen delivery via bovine red blood cell supplementation of culturing media on select metabolic and synthetic functions of C3A hepatocytes maintained within a hollow fiber bioreactor. Artif Cells Blood Substit Immobil Biotechnol 33(3).
    • (2005) Artif Cells Blood Substit Immobil Biotechnol , vol.33 , Issue.3
    • Gordon, J.1    Palmer, A.2
  • 34
    • 0033744730 scopus 로고    scopus 로고
    • Comparison of cell growth in T-flasks, in micro hollow fiber bioreactors, and in an industrial scale hollow fiber bioreactor system
    • Gramer MJ, Poeschl DM. 2000. Comparison of cell growth in T-flasks, in micro hollow fiber bioreactors, and in an industrial scale hollow fiber bioreactor system. Cytotechnology 34(1-2):111-119.
    • (2000) Cytotechnology , vol.34 , Issue.1-2 , pp. 111-119
    • Gramer, M.J.1    Poeschl, D.M.2
  • 37
    • 0034064745 scopus 로고    scopus 로고
    • Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver
    • Hay PD, Veitch AR, Smith MD, Cousins RB, Gaylor JDS. 2000. Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver. Artif Organs 24(4):278-288.
    • (2000) Artif Organs , vol.24 , Issue.4 , pp. 278-288
    • Hay, P.D.1    Veitch, A.R.2    Smith, M.D.3    Cousins, R.B.4    Gaylor, J.D.S.5
  • 38
    • 0035117829 scopus 로고    scopus 로고
    • Oxygen transfer in a convection-enhanced hollow fiber bioartificial liver
    • Hay PD, Veitch AR, Gaylor JDS. 2001. Oxygen transfer in a convection-enhanced hollow fiber bioartificial liver. Artif Organs 25(2):119-130.
    • (2001) Artif Organs , vol.25 , Issue.2 , pp. 119-130
    • Hay, P.D.1    Veitch, A.R.2    Gaylor, J.D.S.3
  • 39
    • 0003043542 scopus 로고
    • The combinations of haemogobin with oxygen and with carbon monoxide
    • Hill AV 1910. The combinations of haemogobin with oxygen and with carbon monoxide. J Physiol 40:iv-vii.
    • (1910) J Physiol , vol.40
    • Hill, A.V.1
  • 40
    • 0024336445 scopus 로고
    • Functional specialization of different hepatocyte populations
    • Jungermann K, Katz N. 1989. Functional specialization of different hepatocyte populations. Physiol Rev 69(3):708-764.
    • (1989) Physiol Rev , vol.69 , Issue.3 , pp. 708-764
    • Jungermann, K.1    Katz, N.2
  • 41
    • 0033960898 scopus 로고    scopus 로고
    • Oxygen: Modulator of metabolic zonation and disease of the liver
    • Jungermann K, Kietzmann T. 2000. Oxygen: Modulator of metabolic zonation and disease of the liver. Hepatology 31(2):255-260.
    • (2000) Hepatology , vol.31 , Issue.2 , pp. 255-260
    • Jungermann, K.1    Kietzmann, T.2
  • 42
    • 0035143253 scopus 로고    scopus 로고
    • Size-dependent in vivo growth potential of adult rat hepatocytes
    • Katayama S, Tateno C, Asahara T, Yoshizato K. 2001. Size-dependent in vivo growth potential of adult rat hepatocytes. Am J Pathol 158(1):97-105.
    • (2001) Am J Pathol , vol.158 , Issue.1 , pp. 97-105
    • Katayama, S.1    Tateno, C.2    Asahara, T.3    Yoshizato, K.4
  • 44
    • 33645558410 scopus 로고    scopus 로고
    • 1994. Permanent human hepatocyte cell line and its use in a liver assist device (LAD). United States patent 5,290,684
    • Kelly JH; Baylor College of Medicine, assignee. 1994. Permanent human hepatocyte cell line and its use in a liver assist device (LAD). United States patent 5,290,684.
    • Kelly, J.H.1
  • 45
    • 0031593187 scopus 로고    scopus 로고
    • Molecular regulation of liver regeneration
    • Ales Prokop DH, Cherrington Alan D, editors. New York: The New York Academy of Sciences
    • Kren BT, Trembley JH, Fan G, Steer CJ. 1997. Molecular regulation of liver regeneration. In: Ales Prokop DH, Cherrington Alan D, editors. Bioartificial organs: Science, medicine, and technology. New York: The New York Academy of Sciences. pp 361-381.
    • (1997) Bioartificial Organs: Science, Medicine, and Technology , pp. 361-381
    • Kren, B.T.1    Trembley, J.H.2    Fan, G.3    Steer, C.J.4
  • 46
    • 84911539247 scopus 로고
    • The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue
    • Krogh A. 1919. The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J Physiol 52:409-415.
    • (1919) J Physiol , vol.52 , pp. 409-415
    • Krogh, A.1
  • 48
    • 11144330501 scopus 로고    scopus 로고
    • Liposome-encapsulated actin-hemoglobin (LEAcHb) artificial blood substitutes
    • Li SL, Nickels J, Palmer AF. 2005. Liposome-encapsulated actin-hemoglobin (LEAcHb) artificial blood substitutes. Biomaterials 26(17):3759-3769.
    • (2005) Biomaterials , vol.26 , Issue.17 , pp. 3759-3769
    • Li, S.L.1    Nickels, J.2    Palmer, A.F.3
  • 50
    • 0036187869 scopus 로고    scopus 로고
    • Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: Effects of glutamine
    • Markley MA, Pierro A, Eaton S. 2002. Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: Effects of glutamine. Clin Sci 102(3):337-344.
    • (2002) Clin Sci , vol.102 , Issue.3 , pp. 337-344
    • Markley, M.A.1    Pierro, A.2    Eaton, S.3
  • 51
    • 0034987185 scopus 로고    scopus 로고
    • Red blood cell aggregation measurements in whole blood and in fibrinogen solutions by different methods
    • Marton Z, Kesmarky G, Vekasi J, Cser A, Russai R, Horvath B, Toth K. 2001. Red blood cell aggregation measurements in whole blood and in fibrinogen solutions by different methods. Clin Hemorheol Microcirc 24(2):75-83.
    • (2001) Clin Hemorheol Microcirc , vol.24 , Issue.2 , pp. 75-83
    • Marton, Z.1    Kesmarky, G.2    Vekasi, J.3    Cser, A.4    Russai, R.5    Horvath, B.6    Toth, K.7
  • 52
    • 0014367798 scopus 로고
    • The influence of hemoglobin diffusion on oxygen uptake and release by red cells
    • Moll W. 1968. The influence of hemoglobin diffusion on oxygen uptake and release by red cells. Respir Physiol 6(1):1-15.
    • (1968) Respir Physiol , vol.6 , Issue.1 , pp. 1-15
    • Moll, W.1
  • 53
    • 0034307432 scopus 로고    scopus 로고
    • Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells
    • Morrison SJ, Csete M, Groves AK, Melega W, Wold B, Anderson DJ. 2000. Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. J Neurosci 20(19):7370-7376.
    • (2000) J Neurosci , vol.20 , Issue.19 , pp. 7370-7376
    • Morrison, S.J.1    Csete, M.2    Groves, A.K.3    Melega, W.4    Wold, B.5    Anderson, D.J.6
  • 54
    • 0034609028 scopus 로고    scopus 로고
    • A model for high-pressure ultrafiltration of blood
    • Moussy Y. 2000. A model for high-pressure ultrafiltration of blood. Biotechnol Bioeng 69(1):21-30.
    • (2000) Biotechnol Bioeng , vol.69 , Issue.1 , pp. 21-30
    • Moussy, Y.1
  • 55
    • 0028200582 scopus 로고
    • Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver
    • Nyberg SL, Remmel RP, Mann HJ, Peshwa MV, Hu WS, Cerra FB. 1994. Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver. Ann Surg 220(1):59-67.
    • (1994) Ann Surg , vol.220 , Issue.1 , pp. 59-67
    • Nyberg, S.L.1    Remmel, R.P.2    Mann, H.J.3    Peshwa, M.V.4    Hu, W.S.5    Cerra, F.B.6
  • 56
    • 0033562516 scopus 로고    scopus 로고
    • Transfer of porcine endogenous retrovirus across hollow fiber membranes-Significance to a bioartificial liver
    • Nyberg SL, Hibbs JR, Hardin JA, Germer JJ, Persing DH. 1999. Transfer of porcine endogenous retrovirus across hollow fiber membranes-Significance to a bioartificial liver. Transplantation 67(9):1251-1255.
    • (1999) Transplantation , vol.67 , Issue.9 , pp. 1251-1255
    • Nyberg, S.L.1    Hibbs, J.R.2    Hardin, J.A.3    Germer, J.J.4    Persing, D.H.5
  • 57
    • 22944461112 scopus 로고    scopus 로고
    • Engineering temperature-sensitive hydrogel nanoparticles entrapping hemoglobin as a novel type of oxygen carrier
    • Patton J, Palmer A. 2005a. Engineering temperature-sensitive hydrogel nanoparticles entrapping hemoglobin as a novel type of oxygen carrier. Biomacromolecules 6(4):2201-2212.
    • (2005) Biomacromolecules , vol.6 , Issue.4 , pp. 2201-2212
    • Patton, J.1    Palmer, A.2
  • 58
    • 14044255326 scopus 로고    scopus 로고
    • Photopolymerization of bovine hemoglobin entrapped nanoscale hydrogel particles within liposomal reactors for use as an artificial blood substitute
    • Patton JN, Palmer AF. 2005b. Photopolymerization of bovine hemoglobin entrapped nanoscale hydrogel particles within liposomal reactors for use as an artificial blood substitute. Biomacromolecules 6(1):414-424.
    • (2005) Biomacromolecules , vol.6 , Issue.1 , pp. 414-424
    • Patton, J.N.1    Palmer, A.F.2
  • 59
    • 0035680559 scopus 로고    scopus 로고
    • Advances in bioartificial liver assist devices. Bioartificial Organs III: Tissue Sourcing, Immunoisolation, and Clinical Trials
    • Patzer JF. 2001. Advances in bioartificial liver assist devices. Bioartificial Organs III: Tissue Sourcing, Immunoisolation, and Clinical Trials. Ann NY Acad Sci 944:320-333.
    • (2001) Ann NY Acad Sci , vol.944 , pp. 320-333
    • Patzer, J.F.1
  • 60
    • 1242342176 scopus 로고    scopus 로고
    • Oxygen consumption in a hollow fiber bioartificial liver-revisited
    • Patzer JF. 2004. Oxygen consumption in a hollow fiber bioartificial liver-revisited. Artif Organs 28(1):83-98.
    • (2004) Artif Organs , vol.28 , Issue.1 , pp. 83-98
    • Patzer, J.F.1
  • 61
    • 0026416462 scopus 로고
    • Model of oxygen-transport limitations in hollow fiber bioreactors
    • Piret JM, Cooney CL. 1991. Model of oxygen-transport limitations in hollow fiber bioreactors. Biotechnol Bioeng 37(1):80-92.
    • (1991) Biotechnol Bioeng , vol.37 , Issue.1 , pp. 80-92
    • Piret, J.M.1    Cooney, C.L.2
  • 62
    • 0024368187 scopus 로고
    • Theory of oxygen-transport to tissue
    • Popel AS. 1989. Theory of oxygen-transport to tissue. Crit Rev Biomed Eng 17(3):257-321.
    • (1989) Crit Rev Biomed Eng , vol.17 , Issue.3 , pp. 257-321
    • Popel, A.S.1
  • 63
    • 0034978754 scopus 로고    scopus 로고
    • Allometry of mammalian cellular oxygen consumption
    • Porter RK. 2001. Allometry of mammalian cellular oxygen consumption. Cell Mol Life Sci 58(5-6):815-822.
    • (2001) Cell Mol Life Sci , vol.58 , Issue.5-6 , pp. 815-822
    • Porter, R.K.1
  • 64
    • 0000560829 scopus 로고
    • Filtration, diffusion, and molecular seiving through porous cellulose membranes
    • Renkin EM. 1954. Filtration, diffusion, and molecular seiving through porous cellulose membranes. J Gen Physiol 38:225-243.
    • (1954) J Gen Physiol , vol.38 , pp. 225-243
    • Renkin, E.M.1
  • 65
    • 0030828096 scopus 로고    scopus 로고
    • Bioartificial liver support: Developments in hepatocyte culture and bioreactor design
    • Riordan S, Williams R. 1997. Bioartificial liver support: Developments in hepatocyte culture and bioreactor design. Br Med Bull 53(4):730-744.
    • (1997) Br Med Bull , vol.53 , Issue.4 , pp. 730-744
    • Riordan, S.1    Williams, R.2
  • 67
    • 0019295929 scopus 로고
    • Transient oxygen-transport in hemoglobin layers under conditions of the micro-circulation
    • Sheth BV, Heliums JD. 1980. Transient oxygen-transport in hemoglobin layers under conditions of the micro-circulation. Ann Biomed Eng 8(3):183-196.
    • (1980) Ann Biomed Eng , vol.8 , Issue.3 , pp. 183-196
    • Sheth, B.V.1    Heliums, J.D.2
  • 68
    • 0034870946 scopus 로고    scopus 로고
    • Identification and control of dissolved oxygen in hybridoma cell culture in a shear sensitive environment
    • Simon L, Karim MN. 2001. Identification and control of dissolved oxygen in hybridoma cell culture in a shear sensitive environment. Biotechnol Progr 17(4):634-642.
    • (2001) Biotechnol Progr , vol.17 , Issue.4 , pp. 634-642
    • Simon, L.1    Karim, M.N.2
  • 69
    • 0034307725 scopus 로고    scopus 로고
    • Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen
    • Studer L, Csete M, Lee SH, Kabbani N, Walikonis J, Wold B, McKay R. 2000. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J Neurosci 20(19):7377-7383.
    • (2000) J Neurosci , vol.20 , Issue.19 , pp. 7377-7383
    • Studer, L.1    Csete, M.2    Lee, S.H.3    Kabbani, N.4    Walikonis, J.5    Wold, B.6    McKay, R.7
  • 70
    • 0035811241 scopus 로고    scopus 로고
    • Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor
    • Tilles AW, Baskaran H, Roy P, Yarmush ML, Toner M. 2001. Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor. Biotechnol Bioeng 73(5):379-389.
    • (2001) Biotechnol Bioeng , vol.73 , Issue.5 , pp. 379-389
    • Tilles, A.W.1    Baskaran, H.2    Roy, P.3    Yarmush, M.L.4    Toner, M.5
  • 72
    • 0032414344 scopus 로고    scopus 로고
    • Comparison of porcine hepatocytes with human hepatoma (C3A) cells for use in a bioartificial liver support system
    • Wang LS, Sun JH, Li L, Mears D, Horvat M, Sheil AGR. 1998. Comparison of porcine hepatocytes with human hepatoma (C3A) cells for use in a bioartificial liver support system. Cell Transplant 7(5):459-468.
    • (1998) Cell Transplant , vol.7 , Issue.5 , pp. 459-468
    • Wang, L.S.1    Sun, J.H.2    Li, L.3    Mears, D.4    Horvat, M.5    Sheil, A.G.R.6
  • 73
    • 0032979184 scopus 로고    scopus 로고
    • Mass transfer limitations in diffusion-limited isotropic hollow fiber bioreactors
    • Willaert R, Smets A, De Vuyst L. 1999. Mass transfer limitations in diffusion-limited isotropic hollow fiber bioreactors. Biotechnol Tech 13(5):317-323.
    • (1999) Biotechnol Tech , vol.13 , Issue.5 , pp. 317-323
    • Willaert, R.1    Smets, A.2    De Vuyst, L.3
  • 74
    • 0035151025 scopus 로고    scopus 로고
    • Improvement of metabolic performance of cultured hepatocytes by high oxygen tension in the atmosphere
    • Yanagi K, Ohshima N. 2001. Improvement of metabolic performance of cultured hepatocytes by high oxygen tension in the atmosphere. Artif Organs 25(1):1-6.
    • (2001) Artif Organs , vol.25 , Issue.1 , pp. 1-6
    • Yanagi, K.1    Ohshima, N.2
  • 75
    • 0023073341 scopus 로고
    • Use of Adiar four-step kinetics in mathematical simulation of oxygen transport in the mirocirculation
    • Yap E, Heliums J. 1987. Use of Adiar four-step kinetics in mathematical simulation of oxygen transport in the mirocirculation. Adv Exp Med Biol 215:193.
    • (1987) Adv Exp Med Biol , vol.215 , pp. 193
    • Yap, E.1    Heliums, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.