Significant survival prolongation in pigs with fulminant hepatic failure treated with a novel microgravity-based bioartificial liver

Artificial Organs

Volumn 30, Issue 12, 2006, Pages 906-914

  Hochleitner, Boris ^a,b   Hengster, Paul ^a   Bucher, Herwig ^a   Ladurner, Ruth ^a   Schneeberger, Stefan ^a   Krismer, Anette ^a   Kleinsasser, Alex ^a   Barnas, Usso ^a   Klima, Günter ^a   Margreiter, Raimund ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b Department of General Surgery ^*  (Austria)

Author keywords

Animal model; Bioreactor; Fulminant hepatic failure; Liver support; Microgravity based bioreactors; Rotating wall vessel

Indexed keywords

AMMONIA; ARTIFICIAL ORGANS; BIOREACTORS; MAMMALS; MICROGRAVITY; MICROGRAVITY PROCESSING; PHOSPHATASES;

ANIMAL MODEL; BIOARTIFICIAL LIVER; BIOREACTOR; FULMINANT HEPATIC FAILURES; HEPATOCYTES; LIVER SUPPORT; MICROGRAVITY-BASED BIOREACTOR; ROTATING WALL VESSELS; SIMULATED MICROGRAVITY; US PATENTS;

BIOCONVERSION;

ALKALINE PHOSPHATASE; AMMONIA; ASPARTATE AMINOTRANSFERASE; LACTIC ACID;

ALKALINE PHOSPHATASE BLOOD LEVEL; AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOARTIFICIAL LIVER; CELL COUNT; CONTROLLED STUDY; INTRACRANIAL PRESSURE; LACTATE BLOOD LEVEL; LIVER CELL; LIVER FAILURE; LIVER RESECTION; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; SWINE;

ANIMALIA; SUIDAE;

EID: 33845496808     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2006.00323.x     Document Type: Article

References (31)

1. Jauregui HO, Mullon CJ, Trenkler D, et al. In vivo evaluation of a hollow fiber liver assist device. Hepatology 1995;21:460-9.
2. Sielaff TD, Hu MY, Amiot B, et al. Gel-entrapment bioartificial liver therapy in galactosamine hepatitis. J Surg Res 1995;59:179-84.
3. Uchino J, Tsuburaya T, Kumagai F, et al. A hybrid bioartificial liver composed of multiplated hepatocyte monolayers. ASAIO Trans 1988;34:972-7.
4. Takahashi M, Matsue H, Matsushita M, et al. Does a porcine hepatocyte hybrid artificial liver prolong the survival time of anhepatic rabbits? ASAIO J 1992;38:M468-72.
5. van de Kerkhove MP, Chamuleau RA, van Gulik TM. Clinical application of bioartificial liver support systems. In: Jones EA, Meijer AJ, Chamuleau RA, eds. Encephalopathy and Nitrogen Metabolism in Liver Failure, Vol. 38. Dordrecht, The Netherlands: Kluwer Academic Publishers, 2003;389-414.
6. Ellis AJ, Hughes RD, Wendon JA, et al. Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure. Hepatology 1996;24:1446-51.
7. Watanabe FD, Mullon CJ, Hewitt WR, et al. Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial. Ann Surg 1997;225:484-91.
8. Xue YL, Zhao SF, Luo Y, et al. TECA hybrid artificial liver support system in treatment of acute liver failure. World J Gastroenterol 2001;7:826-9.
9. Mazariegos GV, Kramer DJ, Lopez RC, et al. Safety observations in phase I clinical evaluation of the Excorp Medical Bioartificial Liver Support System after the first four patients. ASAIO J 2001;47:471-5.
10. Morsiani E, Pazzi P, Puviani AC, et al. Early experiences with a porcine hepatocyte-based bioartificial liver in acute hepatic failure patients. Int J Artif Organs 2002;25:192-202.
11. Mundt A, Puhl G, Muller A, et al. A method to assess biochemical activity of liver cells during clinical application of extracorporeal hybrid liver support. Int J Artif Organs 2002;25:542-8.
12. Donini A, Baccarani U, Risaliti A, Degrassi A, Bresadola F. Temporary neurological improvement in a patient with acute or chronic liver failure treated with a bioartificial liver device. Am J Gastroenterol 2000;95:1102-4.
13. Flendrig LM, te Velde AA, Chamuleau RA. Semipermeable hollow fiber membranes in hepatocyte bioreactors: a prerequisite for a successful bioartificial liver? Artif Organs 1997;21:1177-81.
14. van de Kerkhove MP, Di Florio E, Scuderi V, et al. Phase I clinical trial with the AMC-bioartificial liver. Int J Artif Organs 2002;25:950-9.
15. Hochleitner B, Hengster P, Duo L, Bucher H, Klima G, Margreiter R. A novel bioartificial liver with culture of porcine hepatocyte aggregates under simulated microgravity. Artif Organs 2005;29:58-66.
16. Seglen PO. Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp Cell Res 1973;82:391-8.
17. Coward SM, Selden C, Mantalaris A, Hodgson HJ. Proliferation rates of HepG2 cells encapsulated in alginate are increased in a microgravity environment compared with static cultures. Artif Organs 2005;29:152-8.
18. Terblanche J, Hickman R. Animal models of fulminant hepatic failure. Dig Dis Sci 1991;36:770-4.
19. van de Kerkhove MP, Hoekstra R, van Gulik TM, Chamuleau RA. Large animal models of fulminant hepatic failure in artificial and bioartificial liver support research. Biomaterials 2004;25:1613-25.
20. Karrer FM, Rhenman B, Buckley AR, Steinbronn KK, Putnam CW. A reproducible large animal model of acute hepatic failure. Curr Surg 1984;41:464-7.
21. Filipponi F, Fabbri LP, Marsili M, et al. A new surgical model of acute liver failure in the pig: experimental procedure and analysis of liver injury. Eur Surg Res 1991;23:58-64.
22. Ladurner R, Hochleitner B, Schneeberger S, et al. Extended liver resection and hepatic ischemia in pigs: a new, potentially reversible model to induce acute liver failure and study artificial liver support systems. Eur Surg Res 2005;37:365-9.
23. Khalili TM, Navarro A, Ting P, et al. Bioartificial liver treatment prolongs survival and lowers intracranial pressure in pigs with fulminant hepatic failure. Artif Organs 2001;25:566-70.
24. Sen S, Rose C, Ytrebo LM, et al. Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Crit Care Med 2006;34:158-64.
25. Stange J, Mitzner SR, Risler T, et al. Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver support. Artif Organs 1999;23:319-30.
26. Flendrig LM, Calise F, Di Florio E, et al. Significantly improved survival time in pigs with complete liver ischemia treated with a novel bioartificial liver. Significantly improved survival time in pigs with complete liver ischemia treated with a novel bioartificial liver. Int J Artif Organs 1999;22:701-9.
27. Sosef MN, Abrahamse LS, van de Kerkhove MP, Hartman R, Chamuleau RA, van Gulik TM. Assessment of the AMC-bioartificial liver in the anhepatic pig. Transplantation 2002;27:204-9.
28. Naka S, Takeshita K, Yamamoto T, Tani T, Kodama M. Bioartificial liver support system using porcine hepatocytes entrapped in a three-dimensional hollow fiber module with collagen gel: an evaluation in the swine acute liver failure model. Artif Organs 1999;23:822-8.
29. Kamohara Y, Fujioka H, Eguchi S, Kawashita Y, Furui J, Kanematsu T. Comparative study of bioartificial liver support and plasma exchange for treatment of pigs with fulminant hepatic failure. Artif Organs 2000;24:265-70.
30. Gerlach JC, Botsch M, Kardassis D, et al. Experimental evaluation of a cell module for hybrid liver support. Int J Artif Organs 2001;24:793-8.
31. Fruhauf NR, Oldhafer KJ, Holtje M, et al. A bioartificial liver support system using primary hepatocytes: a preclinical study in a new porcine hepatectomy model. Surgery 2004;136:47-56.