Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis

PLoS Pathogens

Volumn 7, Issue 10, 2011, Pages

  Horstmann, Nicola ^a   Sahasrabhojane, Pranoti ^a   Suber, Bryce ^a   Kumaraswami, Muthiah ^b   Olsen, Randall J ^b   Flores, Anthony ^c   Musser, James M ^b   Brennan, Richard G ^a   Shelburne, Samuel A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b HOUSTON METHODIST HOSPITAL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CONTROL OF VIRULENCE REGULATOR PROTEIN; DNA; RECOMBINANT PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG; VIRULENCE FACTOR; AMINO ACID; BACTERIAL DNA; BACTERIAL RNA; CSRR PROTEIN, STREPTOCOCCUS PYOGENES; REPRESSOR PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA HELIX; FEMALE; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN VARIANT; STREPTOCOCCUS GROUP A; SURVIVAL TIME; WILD TYPE; ANIMAL; CHEMISTRY; DISEASE MODEL; GENETICS; LONGEVITY; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; PATHOGENICITY; PROTEIN SECONDARY STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PYOGENES; VIRULENCE;

MUS; STREPTOCOCCUS SP. 'GROUP A';

AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; DNA, BACTERIAL; FEMALE; LONGEVITY; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STRUCTURE, SECONDARY; REPRESSOR PROTEINS; RNA, BACTERIAL; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; VIRULENCE;

EID: 80055064690     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002311     Document Type: Article

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