Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection

Journal of Infectious Diseases

Volumn 183, Issue 7, 2001, Pages 1043-1054

  Engleberg, N Cary ^a,b   Heath, Andrew ^a   Miller, Alita ^b,c   Rivera, Clarise ^b   DiRita, Victor J ^b,c  

^a Departments of Internal Medicine   (United States)

^b The Department of Microbiology and Immunology   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN CSRRS; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL MUTATION; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BACTERIUM MUTANT; DISEASE SEVERITY; FRAMESHIFT MUTATION; INOCULATION; MOUSE; NECROSIS; NONHUMAN; NONSENSE MUTATION; PLASMID; PRIORITY JOURNAL; SKIN INFECTION; SOFT TISSUE INFECTION; STREPTOCOCCUS PYOGENES;

AMINO ACID SUBSTITUTION; ANIMALS; BACTERIAL CAPSULES; BACTERIAL PROTEINS; BACTERIAL TOXINS; CARRIER PROTEINS; CODON, NONSENSE; DISEASE MODELS, ANIMAL; DNA TRANSPOSABLE ELEMENTS; DNA-BINDING PROTEINS; FRAMESHIFT MUTATION; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED HRS; PLASMIDS; SKIN DISEASES, BACTERIAL; SOFT TISSUE INFECTIONS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; TRANSCRIPTION, GENETIC; VIRULENCE;

EID: 0035313287     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/319291     Document Type: Article

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