CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats

Free Radical Biology and Medicine

Volumn 37, Issue 5, 2004, Pages 703-712

  Minamiyama, Yukiko ^a,b   Takemura, Shigekazu ^b   Toyokuni, Shinya ^c   Imaoka, Susumu ^d   Funae, Yoshihiko ^d   Hirohashi, Kazuhiro ^b   Yoshikawa, Toshikazu ^e   Okada, Shigeru ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Osaka Prefecture University   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

4 hydroxy 2 nonenal; 5,5 dimythyl 1 pyrroline n oxide; alanine aminotransferase; ALT; aspartate aminotransferase; AST; CYP3A2; Cytochrome P450; deoxy guanosine; dG; DHE; dihydroethidium; DMPO; EtBr; ethidium bromide; Free radical; HNE; KCZ; Lipopolysaccharide

Indexed keywords

4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 2B1; CYTOCHROME P450 3A; HYDROETHIDINE; KETOCONAZOLE; LIPOPOLYSACCHARIDE; PHENOBARBITAL; PROTEIN INHIBITOR; SUPEROXIDE DISMUTASE; TROLEANDOMYCIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; LIVER CELL NUCLEUS; LIVER INJURY; LIVER MICROSOME; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; ENDOTOXEMIA; ENZYME INDUCTION; LIPOPOLYSACCHARIDES; LIVER; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 3343005604     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.05.022     Document Type: Article

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