An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon

International Journal of Pharmaceutics

Volumn 239, Issue 1-2, 2002, Pages 197-205

  Zhang, Hua ^a   Alsarra, Ibrahim A ^a   Neau, Steven H ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Almond emulsin beta glucosidase; Chitosan; Colon specific drug delivery; Hydrogel beads; Multiparticulates; Rat microbial enzymes

Indexed keywords

BETA GLUCOSIDASE; BOVINE SERUM ALBUMIN; CHITINASE; CHITOSAN; FLUORESCEIN ISOTHIOCYANATE; INTESTINE ENZYME; POLYELECTROLYTE; TRIPOLYPHOSPHATE;

ACCELERATION; ARTICLE; CECUM; COLON; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SCREENING; ENZYMATIC DEGRADATION; HYDROGEL; IN VITRO STUDY; INTESTINE ABSORPTION; MACROMOLECULE; MALE; NONHUMAN; PARTICULATE MATTER; PH; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SIMULATION;

ANIMALS; CECUM; CHITIN; CHITOSAN; COLON; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FLUORESCEIN-5-ISOTHIOCYANATE; HYDROGELS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INTESTINAL ABSORPTION; PARTICLE SIZE; RATS; SERUM ALBUMIN, BOVINE; VISCOSITY;

EID: 0037018961     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00112-6     Document Type: Article

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