Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: Ligand-directed chiral recognition

Chirality

Volumn 23, Issue 1 E, 2011, Pages

  Jozwiak, Krzysztof ^a   Plazinska, Anita ^a   Toll, Lawrence ^b   Jimenez, Lucita ^b   Woo, Anthony Yiu Ho ^c   Xiao, Rui Ping ^c   Wainer, Irving W ^c  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b SRI INTERNATIONAL   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

2 adrenergic agonists; affinity; efficacy; G protein coupled receptors; stereoselective binding; Van't Hoff analysis

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; FENOTEROL; G PROTEIN COUPLED RECEPTOR;

ANIMAL TISSUE; BINDING AFFINITY; BINDING SITE; CELL PROLIFERATION; CHIRALITY; CONTROLLED STUDY; DRUG CONFORMATION; ENANTIOSELECTIVITY; ENTHALPY; ENTROPY; HEART MUSCLE CELL; ISOMER; LIGAND BINDING; MOLECULAR RECOGNITION; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; STEREOCHEMISTRY; STEREOISOMERISM; THERMODYNAMICS;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; CELL LINE, TUMOR; ENTROPY; FENOTEROL; GTP-BINDING PROTEINS; HOT TEMPERATURE; HUMANS; KINETICS; LIGANDS; MODELS, CHEMICAL; RATS; RECEPTORS, ADRENERGIC, BETA-2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; THERMODYNAMICS;

EID: 80055007377     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20963     Document Type: Review

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