The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the β2-adrenoceptor

Biochemical Pharmacology

Volumn 79, Issue 11, 2010, Pages 1610-1615

  Jozwiak, Krzysztof ^a   Toll, Lawrence ^b   Jimenez, Lucita ^b   Woo, Anthony Yiu Ho ^c   Xiao, Rui Ping ^c   Wainer, Irving W ^c  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b SRI INTERNATIONAL   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Binding mechanisms; Binding thermodynamics; Chirality; Enantiomers; Enantiospecific binding; Thermodynamic agonist antagonist discrimination

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; COMPLEMENTARY DNA; FENOTEROL; ISOPRENALINE; PROPRANOLOL;

ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENTHALPY; ENTROPY; HUMAN; HUMAN CELL; MEMBRANE BINDING; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOISOMERISM; TEMPERATURE SENSITIVITY; THERMODYNAMICS;

ADRENERGIC BETA-AGONISTS; BINDING, COMPETITIVE; CELL LINE; FENOTEROL; HUMANS; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-2; STEREOISOMERISM; THERMODYNAMICS;

EID: 77950078520     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.01.035     Document Type: Article

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