Inhibition of geranylgeranyl transferase-I decreases cell viability of HTLV-1-transformed cells

Viruses

Volumn 3, Issue 10, 2011, Pages 1815-1835

  Edwards, Dustin C ^a   Mckinnon, Katherine M ^a   Fenizia, Claudio ^a   Jung, Kyung Jin ^a   Brady, John N ^a   Pise Masison, Cynthia A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cell cycle; Geranylgeranyltransferase; GGTI 298; HTLV 1; Human T cell leukemia virus type 1; Long terminal repeat; LTR; NF B; P53; Small GTpase; Tax

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; DIMETHYL SULFOXIDE; GERANYLGERANYL TRANSFERASE 1; GGTI 298; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LUCIFERASE; MESSENGER RNA; PROTEIN P53; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RNA 18S; TAX PROTEIN; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL SPECIFICITY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DENSITOMETRY; DNA BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PRENYLATION; VIRUS CELL TRANSFORMATION;

CELL CYCLE; GERANYLGERANYLTRANSFERASE; GGTI-298; HTLV-1; HUMAN T-CELL LEUKEMIA VIRUS TYPE-1; LONG TERMINAL REPEAT; LTR; NF-ΚB; P53; SMALL GTPASE; TAX;

ALKYL AND ARYL TRANSFERASES; BENZAMIDES; CELL CYCLE; CELL LINE, TRANSFORMED; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; I-KAPPA B PROTEINS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; NF-KAPPA B; PHOSPHORYLATION; PROTEIN PRENYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 80055001132     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v3101815     Document Type: Article

References (52)

1. Edlich, R.F.; Arnette, J.A.; Williams, F.M. Global epidemic of human T-cell lymphotropic virus type-I (HTLV-I). J. Emerg. Med. 2000, 18, 109-119.
2. Poiesz, B.J.; Ruscetti, F.W.; Gazdar, A.F.; Bunn, P.A.; Minna, J.D.; Gallo, R.C. Detection and isolation of type c retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. U. S. A. 1980, 77, 7415-7419.
3. Yoshida, M.; Miyoshi, I.; Hinuma, Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc. Natl. Acad. Sci. U. S. A. 1982, 79, 2031-2035.
4. Gessain, A.; Barin, F.; Vernant, J.C.; Gout, O.; Maurs, L.; Calender, A.; de The, G. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985, 2, 407-410.
5. Nakamura, F.; Kajihara, H.; Nakamura, M.; Sasaki, H.; Kumamoto, T.; Okada, K. HTLV-1 associated myelopathy in an HTLV-1 and HBV double carrier family: Report of a case and the mode of vertical transmission of both viruses. J. Gastroenterol. Hepatol. 1989, 4, 387-390.
6. Osame, M.; Usuku, K.; Izumo, S.; Ijichi, N.; Amitani, H.; Igata, A.; Matsumoto, M.; Tara, M. HTLV-I associated myelopathy, a new clinical entity. Lancet 1986, 1, 1031-1032.
7. Murphy, E.L.; Hanchard, B.; Figueroa, J.P.; Gibbs, W.N.; Lofters, W.S.; Campbell, M.; Goedert, J.J.; Blattner, W.A. Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human t-lymphotropic virus type I. Int. J. Cancer 1989, 43, 250-253.
8. Marriott, S.J.; Semmes, O.J. Impact of HTLV-I tax on cell cycle progression and the cellular DNA damage repair response. Oncogene 2005, 24, 5986-5995.
9. Grassmann, R.; Aboud, M.; Jeang, K.T. Molecular mechanisms of cellular transformation by HTLV-1 tax. Oncogene 2005, 24, 5976-5985.
10. Jeong, S.J.; Pise-Masison, C.A.; Radonovich, M.F.; Park, H.U.; Brady, J.N. Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Oncogene 2005, 24, 6719-6728.
11. Tabakin-Fix, Y.; Azran, I.; Schavinky-Khrapunsky, Y.; Levy, O.; Aboud, M. Functional inactivation of p53 by human T-cell leukemia virus type 1 tax protein: Mechanisms and clinical implications. Carcinogenesis 2006, 27, 673-681.
12. Taylor, J.M.; Nicot, C. HTLV-1 and apoptosis: Role in cellular transformation and recent advances in therapeutic approaches. Apoptosis 2008, 13, 733-747.
13. Dasgupta, A.; Jung, K.J.; Jeong, S.J.; Brady, J.N. Inhibition of methyltransferases results in induction of G2/M checkpoint and programmed cell death in human T-lymphotropic virus type 1-transformed cells. J. Virol. 2008, 82, 49-59.
14. Jung, K.J.; Dasgupta, A.; Huang, K.; Jeong, S.J.; Pise-Masison, C.; Gurova, K.V.; Brady, J.N. Small-molecule inhibitor which reactivates p53 in human T-cell leukemia virus type 1-transformed cells. J. Virol. 2008, 82, 8537-8547.
15. Vogt, A.; Sun, J.; Qian, Y.; Hamilton, A.D.; Sebti, S.M. The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. J. Biol. Chem. 1997, 272, 27224-27229.
16. Vitale, M.; Di Matola, T.; Rossi, G.; Laezza, C.; Fenzi, G.; Bifulco, M. Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism. Endocrinology 1999, 140, 698-704.
17. Dan, H.C.; Jiang, K.; Coppola, D.; Hamilton, A.; Nicosia, S.V.; Sebti, S.M.; Cheng, J.Q. Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene 2004, 23, 706-715.
18. Konstantinopoulos, P.A.; Karamouzis, M.V.; Papavassiliou, A.G. Post-translational modifications and regulation of the Ras superfamily of GTPases as anticancer targets. Nat. Rev. Drug Discov. 2007, 6, 541-555.
19. Khwaja, A.; Sharpe, C.C.; Noor, M.; Hendry, B.M. The role of geranylgeranylated proteins in human mesangial cell proliferation. Kidney Int. 2006, 70, 1296-1304.
20. Forsberg, M.; Blomgran, R.; Lerm, M.; Sarndahl, E.; Sebti, S.M.; Hamilton, A.; Stendahl, O.; Zheng, L. Differential effects of invasion by and phagocytosis of salmonella typhimurium on apoptosis in human macrophages: Potential role of Rho-GTPases and Akt. J. Leuk. Biol. 2003, 74, 620-629.
21. Ramirez, S.; Ait-Si-Ali, S.; Robin, P.; Trouche, D.; Harel-Bellan, A. The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element. J. Biol. Chem. 1997, 272, 31016-31021.
22. Hill, C.S.; Wynne, J.; Treisman, R. The Rho family GTPases RhoA, Rac1, and Cdc42Hs regulate transcriptional activation by SRF. Cell 1995, 81, 1159-1170.
23. Minden, A.; Lin, A.; Claret, F.X.; Abo, A.; Karin, M. Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 1995, 81, 1147-1157.
24. Perona, R.; Montaner, S.; Saniger, L.; Sanchez-Perez, I.; Bravo, R.; Lacal, J.C. Activation of the nuclear factor-kappaB by Rho, Cdc42, and Rac-1 proteins. Genes Dev. 1997, 11, 463-475.
25. Kashanchi, F.; Brady, J.N. Transcriptional and post-transcriptional gene regulation of HTLV-1. Oncogene 2005, 24, 5938-5951.
26. Casey, P.J.; Seabra, M.C. Protein prenyltransferases. J. Biol. Chem. 1996, 271, 5289-5292.
27. Stark, W.W., Jr.; Blaskovich, M.A.; Johnson, B.A.; Qian, Y.; Vasudevan, A.; Pitt, B.; Hamilton, A.D.; Sebti, S.M.; Davies, P. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. Am. J. Physiol. 1998, 275, L55-L63.
28. Nonaka, M.; Uota, S.; Saitoh, Y.; Takahashi, M.; Sugimoto, H.; Amet, T.; Arai, A.; Miura, O.; Yamamoto, N.; Yamaoka, S. Role for protein geranylgeranylation in adult T-cell leukemia cell survival. Exp. Cell Res. 2009, 315, 141-150.
29. Miquel, K.; Pradines, A.; Sun, J.; Qian, Y.; Hamilton, A.D.; Sebti, S.M.; Favre, G. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. Cancer Res. 1997, 57, 1846-1850.
30. Sun, J.; Qian, Y.; Chen, Z.; Marfurt, J.; Hamilton, A.D.; Sebti, S.M. The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity. J. Biol. Chem. 1999, 274, 6930-6934.
31. Li, X.; Liu, L.; Tupper, J.C.; Bannerman, D.D.; Winn, R.K.; Sebti, S.M.; Hamilton, A.D.; Harlan, J.M. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. J. Biol. Chem. 2002, 277, 15309-15316.
32. van de Donk, N.W.; Schotte, D.; Kamphuis, M.M.; van Marion, A.M.; van Kessel, B.; Bloem, A.C.; Lokhorst, H.M. Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells. Clin. Cancer Res. 2003, 9, 5735-5748.
33. van de Donk, N.W.; Kamphuis, M.M.; van Kessel, B.; Lokhorst, H.M.; Bloem, A.C. Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels. Blood 2003, 102, 3354-3362.
34. Ageberg, M.; Rydstrom, K.; Linden, O.; Linderoth, J.; Jerkeman, M.; Drott, K. Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines. Exp. Cell Res. 2011, 317, 1179-1191.
35. Liu, L.; Moesner, P.; Kovach, N.L.; Bailey, R.; Hamilton, A.D.; Sebti, S.M.; Harlan, J.M. Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s). J. Biol. Chem. 1999, 274, 33334-33340.
36. Efuet, E.T.; Keyomarsi, K. Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome. Cancer Res. 2006, 66, 1040-1051.
37. Allal, C.; Pradines, A.; Hamilton, A.D.; Sebti, S.M.; Favre, G. Farnesylated Rhob prevents cell cycle arrest and actin cytoskeleton disruption caused by the geranylgeranyltransferase I inhibitor GGTI-298. Cell Cycle 2002, 1, 430-437.
38. Nomura, M.; Ohashi, T.; Nishikawa, K.; Nishitsuji, H.; Kurihara, K.; Hasegawa, A.; Furuta, R.A.; Fujisawa, J.; Tanaka, Y.; Hanabuchi, S.; Harashima, N.; Masuda, T.; Kannagi, M. Repression of tax expression is associated both with resistance of human T-cell leukemia virus type 1-infected T cells to killing by tax-specific cytotoxic T lymphocytes and with impaired tumorigenicity in a rat model. J. Virol. 2004, 78, 3827-3836.
39. Aznar, S.; Fernandez-Valeron, P.; Espina, C.; Lacal, J.C. Rho GTPases: Potential candidates for anticancer therapy. Cancer Lett. 2004, 206, 181-191.
40. Wu, K.; Bottazzi, M.E.; de la Fuente, C.; Deng, L.; Gitlin, S.D.; Maddukuri, A.; Dadgar, S.; Li, H.; Vertes, A.; Pumfery, A.; Kashanchi, F. Protein profile of tax-associated complexes. J. Biol. Chem. 2004, 279, 495-508.
41. Klener, P.; Szynal, M.; Cleuter, Y.; Merimi, M.; Duvillier, H.; Lallemand, F.; Bagnis, C.; Griebel, P.; Sotiriou, C.; Burny, A.; Martiat, P.; Van den Broeke, A. Insights into gene expression changes impacting B-cell transformation: Cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells. J. Virol. 2006, 80, 1922-1938.
42. Ishikawa, C.; Matsuda, T.; Okudaira, T.; Tomita, M.; Kawakami, H.; Tanaka, Y.; Masuda, M.; Ohshiro, K.; Ohta, T.; Mori, N. Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway. Br. J. Haematol. 2007, 136, 424-432.
43. Uchiyama, T.; Ishikawa, T.; Imura, A. Adhesion properties of adult T cell leukemia cells. Leuk. Lymphoma 1995, 16, 407-412.
44. Tanaka, Y.; Mine, S.; Figdor, C.G.; Wake, A.; Hirano, H.; Tsukada, J.; Aso, M.; Fujii, K.; Saito, K.; van Kooyk, Y.; Eto, S. Constitutive chemokine production results in activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells. Blood 1998, 91, 3909-3919.
45. Infante, E.; Heasman, S.J.; Ridley, A.J. Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b. J. Leuk. Biol. 2011, 89, 577-586.
46. Van Prooyen, N.; Gold, H.; Andresen, V.; Schwartz, O.; Jones, K.; Ruscetti, F.; Lockett, S.; Gudla, P.; Venzon, D.; Franchini, G. Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission. Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 20738-20743.
47. Kim, S.J.; Nair, A.M.; Fernandez, S.; Mathes, L.; Lairmore, M.D. Enhancement of LFA-1-mediated T cell adhesion by human T lymphotropic virus type 1 p12I1. J. Immunol. 2006, 176, 5463-5470.
48. AlphaEase FC, 6.0.0; 2006, Alpha Innotech: Santa Clara, CA, USA.
49. Modfit lt, 3.2; 2008, Verity Software House: Topsham, ME, USA.
50. Flowjo, 9.3.2; 2008, Tree Star: Ashland, OR, USA.
51. Rende, F.; Cavallari, I.; Corradin, A.; Silic-Benussi, M.; Toulza, F.; Toffolo, G.M.; Tanaka, Y.; Jacobson, S.; Taylor, G.P.; D'Agostino, D.M.; Bangham, C.R.; Ciminale, V. Kinetics and intracellular compartmentalization of HTLV-1 gene expression: Nuclear retention of HBZ mRNAs. Blood 2011, 117, 4855-4859.
52. Cho, W.K.; Zhou, M.; Jang, M.K.; Huang, K.; Jeong, S.J.; Ozato, K.; Brady, J.N. Modulation of the Brd4/P-TEFb interaction by the human T-lymphotropic virus type 1 tax protein. J. Virol. 2007, 81, 11179-11186.