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Volumn 82, Issue 17, 2008, Pages 8537-8547

Small-molecule inhibitor which reactivates p53 in human T-cell leukemia virus type 1-transformed cells

Author keywords

[No Author keywords available]

Indexed keywords

AMINOACRIDINE; PROTEIN P53;

EID: 50149108780     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00690-08     Document Type: Article
Times cited : (21)

References (49)
  • 1
    • 0028858129 scopus 로고
    • Characterization of T cells immortalized by Taxi of human T-cell leukemia virus type 1
    • Akagi, T., H. Ono, and K. Shimotohno. 1995. Characterization of T cells immortalized by Taxi of human T-cell leukemia virus type 1. Blood 86:4243-4249.
    • (1995) Blood , vol.86 , pp. 4243-4249
    • Akagi, T.1    Ono, H.2    Shimotohno, K.3
  • 3
    • 25444474750 scopus 로고    scopus 로고
    • Cellular immune response to HTLV-1
    • Bangham, C. R., and M. Osame. 2005. Cellular immune response to HTLV-1. Oncogene 24:6035-6046.
    • (2005) Oncogene , vol.24 , pp. 6035-6046
    • Bangham, C.R.1    Osame, M.2
  • 4
    • 0031731595 scopus 로고    scopus 로고
    • Regulation of gene expression by HTLV-I Tax protein
    • Bex, F., and R. B. Gaynor. 1998. Regulation of gene expression by HTLV-I Tax protein. Methods 16:83-94.
    • (1998) Methods , vol.16 , pp. 83-94
    • Bex, F.1    Gaynor, R.B.2
  • 6
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S. R., A. Brunet, and M. E. Greenberg. 1999. Cellular survival: a play in three Akts. Genes Dev. 13:2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 7
    • 0034329302 scopus 로고    scopus 로고
    • Gene expression array of HTLV type 1-infected T cells: Up-regulation of transcription factors and cell cycle genes
    • de La Fuente, C., L. Deng, F. Santiago, L. Arce, L. Wang, and F. Kashanchi. 2000. Gene expression array of HTLV type 1-infected T cells: up-regulation of transcription factors and cell cycle genes. AIDS Res. Hum. Retrovir. 16:1695-1700.
    • (2000) AIDS Res. Hum. Retrovir , vol.16 , pp. 1695-1700
    • de La Fuente, C.1    Deng, L.2    Santiago, F.3    Arce, L.4    Wang, L.5    Kashanchi, F.6
  • 9
    • 0028889114 scopus 로고
    • Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I
    • Grossman, W. J., J. T. Kimata, F. H. Wong, M. Zutter, T. J. Ley, and L. Ratner. 1995. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 92:1057-1061.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1057-1061
    • Grossman, W.J.1    Kimata, J.T.2    Wong, F.H.3    Zutter, M.4    Ley, T.J.5    Ratner, L.6
  • 13
    • 0035139943 scopus 로고    scopus 로고
    • Hostile takeovers: Viral appropriation of the NF-κB pathway
    • Hiscott, J., H. Kwon, and P. Genin. 2001. Hostile takeovers: viral appropriation of the NF-κB pathway. J. Clin. Investig. 107:143-151.
    • (2001) J. Clin. Investig , vol.107 , pp. 143-151
    • Hiscott, J.1    Kwon, H.2    Genin, P.3
  • 14
    • 0034948701 scopus 로고    scopus 로고
    • Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: Cellular signaling through NF-κB
    • Jeang, K. T. 2001. Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κB. Cytokine Growth Factor Rev. 12:207-217.
    • (2001) Cytokine Growth Factor Rev , vol.12 , pp. 207-217
    • Jeang, K.T.1
  • 15
    • 3543010169 scopus 로고    scopus 로고
    • Life, death, and tax: Role of HTLV-I oncoprotein in genetic instability and cellular transformation
    • Jeang, K. T., C. Z. Giam, F. Majone, and M. Aboud. 2004. Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation. J. Biol. Chem. 279:31991-31994.
    • (2004) J. Biol. Chem , vol.279 , pp. 31991-31994
    • Jeang, K.T.1    Giam, C.Z.2    Majone, F.3    Aboud, M.4
  • 16
    • 36749014979 scopus 로고    scopus 로고
    • PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells
    • Jeong, S. J., A. Dasgupta, K. J. Jung, J. H. Um, A. Burke, H. U. Park, and J. N. Brady. 2008. PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology 370:264-272.
    • (2008) Virology , vol.370 , pp. 264-272
    • Jeong, S.J.1    Dasgupta, A.2    Jung, K.J.3    Um, J.H.4    Burke, A.5    Park, H.U.6    Brady, J.N.7
  • 17
    • 27144477415 scopus 로고    scopus 로고
    • Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
    • Jeong, S. J., C. A. Pise-Masison, M. F. Radonovich, H. U. Park, and J. N. Brady. 2005. Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Oncogene 24:6719-6728.
    • (2005) Oncogene , vol.24 , pp. 6719-6728
    • Jeong, S.J.1    Pise-Masison, C.A.2    Radonovich, M.F.3    Park, H.U.4    Brady, J.N.5
  • 18
    • 4444226454 scopus 로고    scopus 로고
    • HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity
    • Jeong, S. J., M. Radonovich, J. N. Brady, and C. A. Pise-Masison. 2004. HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity. Blood 104:1490-1497.
    • (2004) Blood , vol.104 , pp. 1490-1497
    • Jeong, S.J.1    Radonovich, M.2    Brady, J.N.3    Pise-Masison, C.A.4
  • 19
    • 0037428385 scopus 로고    scopus 로고
    • The NF-κB activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536
    • Jiang, X., N. Takahashi, N. Matsui, T. Tetsuka, and T. Okamoto. 2003. The NF-κB activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536. J. Biol. Chem. 278:919-926.
    • (2003) J. Biol. Chem , vol.278 , pp. 919-926
    • Jiang, X.1    Takahashi, N.2    Matsui, N.3    Tetsuka, T.4    Okamoto, T.5
  • 21
    • 0031912087 scopus 로고    scopus 로고
    • In vitro and in vivo oncogenic potential of bovine leukemia virus G4 protein
    • Kerkhofs, P., H. Heremans, A. Burny, R. Kettmann, and L. Willems. 1998. In vitro and in vivo oncogenic potential of bovine leukemia virus G4 protein. J. Virol. 72:2554-2559.
    • (1998) J. Virol , vol.72 , pp. 2554-2559
    • Kerkhofs, P.1    Heremans, H.2    Burny, A.3    Kettmann, R.4    Willems, L.5
  • 23
    • 0035379555 scopus 로고    scopus 로고
    • Madrid, L. V., M. W. Mayo, J. Y. Reuther, and A. S. Baldwin, Jr. 2001. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38. J. Biol. Chem. 276:18934-18940.
    • Madrid, L. V., M. W. Mayo, J. Y. Reuther, and A. S. Baldwin, Jr. 2001. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38. J. Biol. Chem. 276:18934-18940.
  • 24
    • 0036710512 scopus 로고    scopus 로고
    • The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
    • Mayo, L. D., and D. B. Donner. 2002. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem. Sci. 27:462-467.
    • (2002) Trends Biochem. Sci , vol.27 , pp. 462-467
    • Mayo, L.D.1    Donner, D.B.2
  • 25
    • 0023189928 scopus 로고
    • The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice
    • Nerenberg, M., S. H. Hinrichs, R. K. Reynolds, G. Khoury, and G. Jay. 1987. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237:1324-1329.
    • (1987) Science , vol.237 , pp. 1324-1329
    • Nerenberg, M.1    Hinrichs, S.H.2    Reynolds, R.K.3    Khoury, G.4    Jay, G.5
  • 27
    • 2442577087 scopus 로고    scopus 로고
    • Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-κB requires IκB kinase-1-mediated phosphorylation of RelA/p65
    • O'Mahony, A. M., M. Montano, K. Van Beneden, L. F. Chen, and W. C. Greene. 2004. Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-κB requires IκB kinase-1-mediated phosphorylation of RelA/p65. J. Biol. Chem. 279:18137-18145.
    • (2004) J. Biol. Chem , vol.279 , pp. 18137-18145
    • O'Mahony, A.M.1    Montano, M.2    Van Beneden, K.3    Chen, L.F.4    Greene, W.C.5
  • 28
    • 0036020941 scopus 로고    scopus 로고
    • Orlowski, R. Z., and A. S. Baldwin, Jr. 2002. NF-κB as a therapeutic target in cancer. Trends Mol. Med. 8:385-389.
    • Orlowski, R. Z., and A. S. Baldwin, Jr. 2002. NF-κB as a therapeutic target in cancer. Trends Mol. Med. 8:385-389.
  • 30
    • 0033517189 scopus 로고    scopus 로고
    • NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes, O. N., L. D. Mayo, J. A. Gustin, S. R. Pfeffer, L. M. Pfeffer, and D. B. Donner. 1999. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85.
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 31
    • 33646847837 scopus 로고    scopus 로고
    • Role for Akt/protein kinase B and activator protcin-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein
    • Peloponese, J. M., Jr., and K. T. Jeang. 2006. Role for Akt/protein kinase B and activator protcin-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein. J. Biol. Chem. 281:8927-8938.
    • (2006) J. Biol. Chem , vol.281 , pp. 8927-8938
    • Peloponese Jr., J.M.1    Jeang, K.T.2
  • 32
    • 28444474333 scopus 로고    scopus 로고
    • Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function
    • Pise-Masison, C. A., and J. N. Brady. 2005. Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function. Front. Biosci. 10:919-930.
    • (2005) Front. Biosci , vol.10 , pp. 919-930
    • Pise-Masison, C.A.1    Brady, J.N.2
  • 33
    • 31944442821 scopus 로고    scopus 로고
    • Human T cell leukemia virus type 1: The role of Tax in leukemogcnesis
    • Pise-Masison, C. A., S. J. Jeong, and J. N. Brady. 2005. Human T cell leukemia virus type 1: the role of Tax in leukemogcnesis. Arch. Immunol. Ther. Exp. 53:283-296.
    • (2005) Arch. Immunol. Ther. Exp , vol.53 , pp. 283-296
    • Pise-Masison, C.A.1    Jeong, S.J.2    Brady, J.N.3
  • 34
    • 0034053965 scopus 로고    scopus 로고
    • Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-κB pathway and is dependent on p53 phosphorylation
    • Pise-Masison, C. A., R. Mahieux, H. Jiang, M. Ashcroft, M. Radonovich, J. Duvall, C. Guillerm, and J. N. Brady. 2000. Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-κB pathway and is dependent on p53 phosphorylation. Mol. Cell. Biol. 20:3377-3386.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 3377-3386
    • Pise-Masison, C.A.1    Mahieux, R.2    Jiang, H.3    Ashcroft, M.4    Radonovich, M.5    Duvall, J.6    Guillerm, C.7    Brady, J.N.8
  • 35
    • 0035808412 scopus 로고    scopus 로고
    • Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent
    • Pise-Masison, C. A., R. Mahieux, M. Radonovich, H. Jiang, and J. N. Brady. 2001. Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent. J. Biol. Chem. 276:200-205.
    • (2001) J. Biol. Chem , vol.276 , pp. 200-205
    • Pise-Masison, C.A.1    Mahieux, R.2    Radonovich, M.3    Jiang, H.4    Brady, J.N.5
  • 36
    • 0025037838 scopus 로고
    • The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells
    • Pozzatti, R., J. Vogel, and G. Jay. 1990. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol. Cell. Biol. 10:413-417.
    • (1990) Mol. Cell. Biol , vol.10 , pp. 413-417
    • Pozzatti, R.1    Vogel, J.2    Jay, G.3
  • 37
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives, C., and P. A. Hall. 1999. The p53 pathway. J. Pathol. 187:112-126.
    • (1999) J. Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 38
    • 0034329283 scopus 로고    scopus 로고
    • Studies of the immortalizing activity of HTLV type 1 Tax, using an infectious molecular clone and transgenic mice
    • Ratner, L., T. Portis, M. Robek, J. Harding, and W. Grossman. 2000. Studies of the immortalizing activity of HTLV type 1 Tax, using an infectious molecular clone and transgenic mice. AIDS Res. Hum Retrovir. 16:1647-1651.
    • (2000) AIDS Res. Hum Retrovir , vol.16 , pp. 1647-1651
    • Ratner, L.1    Portis, T.2    Robek, M.3    Harding, J.4    Grossman, W.5
  • 39
    • 0033517190 scopus 로고    scopus 로고
    • NF-κB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova, J. A., and S. S. Makarov. 1999. NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401:86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 40
    • 0032589462 scopus 로고    scopus 로고
    • IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain
    • Sakurai, H., H. Chiba, H. Miyoshi, T. Sugita, and W. Toriumi. 1999. IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain. J. Biol. Chem. 274:30353-30356.
    • (1999) J. Biol. Chem , vol.274 , pp. 30353-30356
    • Sakurai, H.1    Chiba, H.2    Miyoshi, H.3    Sugita, T.4    Toriumi, W.5
  • 41
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
    • Sizemore, N., S. Leung, and G. R. Stark. 1999. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol. Cell. Biol. 19:4798-4805.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 4798-4805
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 43
    • 0023224532 scopus 로고
    • The role of inhibitors in the fluorescent staining of benign naevus and malignant melanoma cells with 9-amino acridinc and acridine orange
    • Steven, F. S., U. Suresh, T. L. Wong, and M. M. Griffin. 1987. The role of inhibitors in the fluorescent staining of benign naevus and malignant melanoma cells with 9-amino acridinc and acridine orange. J. Enzyme Inhib. 1:275-287.
    • (1987) J. Enzyme Inhib , vol.1 , pp. 275-287
    • Steven, F.S.1    Suresh, U.2    Wong, T.L.3    Griffin, M.M.4
  • 45
  • 46
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden, K. H., and X. Lu. 2002. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2:594-604.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 47
    • 0035177432 scopus 로고    scopus 로고
    • Acridine-a neglected antibacterial chromophore
    • Wainwright, M. 2001. Acridine-a neglected antibacterial chromophore. J. Antimicrob. Chemother. 47:1-13.
    • (2001) J. Antimicrob. Chemother , vol.47 , pp. 1-13
    • Wainwright, M.1
  • 48
    • 42249093865 scopus 로고    scopus 로고
    • Wu, W., K. Kehn-Hall, C. Pedati, L. Zweier, I. Castro, Z. Klase, C. S. Dowd, L. Dubrovsky, M. Bukrinsky, and F. Kashanchi. 2008. Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation. Virol. J. 5:41.
    • Wu, W., K. Kehn-Hall, C. Pedati, L. Zweier, I. Castro, Z. Klase, C. S. Dowd, L. Dubrovsky, M. Bukrinsky, and F. Kashanchi. 2008. Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation. Virol. J. 5:41.
  • 49
    • 0035064503 scopus 로고    scopus 로고
    • Multiple viral strategies of HTLV-1 for dysregulation of cell growth control
    • Yoshida, M. 2001. Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu. Rev. Immunol. 19:475-496.
    • (2001) Annu. Rev. Immunol , vol.19 , pp. 475-496
    • Yoshida, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.