Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 48, 2010, Pages 20738-20743

  Van Prooyen, Nancy ^a,b   Gold, Heather ^a   Andresen, Vibeke ^a   Schwartz, Owen ^c   Jones, Kathryn ^d   Ruscetti, Frank ^e   Lockett, Stephen ^e   Gudla, Prabhakar ^d   Venzon, David ^f   Franchini, Genoveffa ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d SAIC FREDERICK INC   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Human leukemia retrovirus; Orf I

Indexed keywords

GAG PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; LYMPHOCYTE ANTIGEN; PROTEIN P8;

CELL CONTACT; CELL SURFACE; CLINICAL ASSESSMENT; CONFERENCE PAPER; CONJUGATION; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOSURVEILLANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; T LYMPHOCYTE; VIRUS TRANSMISSION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 78650552900     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1009635107     Document Type: Article

References (47)

1. Poiesz BJ, et al. (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77:7415-7419.
2. Gallo RC (1986) The first human retrovirus. Sci Am 255:88-98.
3. Gessain A, et al. (1985) Antibodies to human T-lymphotropic virus type I in patients with tropical spastic paraparesis. Lancet 2:407-410.
4. Koralnik IJ, et al. (1992) Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I. Proc Natl Acad Sci USA 89:8813-8817.
5. Ciminale V, et al. (1995) Expression and characterization of proteins produced by mRNAs spliced into the X region of the human T-cell leukemia/lymphotropic virus type II. Virology 209:445-456.
6. Nicot C, et al. (2004) HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat Med 10:197-201.
7. Gaudray G, et al. (2002) The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol 76:12813-12822.
8. Fukumoto R, et al. (2009) In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein. Blood 113:3726-3734.
9. Fukumoto R, et al. (2007) Inhibition of T-cell receptor signal transduction and viral expression by the linker for activation of T cells-interacting p12(I) protein of human Tcell leukemia/lymphoma virus type 1. J Virol 81:9088-9099.
10. Albrecht B, et al. (2002) Activation of nuclear factor of activated T cells by human Tlymphotropic virus type 1 accessory protein p12(I). J Virol 76:3493-3501.
11. Mulloy JC, Crownley RW, Fullen J, Leonard WJ, Franchini G (1996) The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor β and gammac chains and affects their expression on the cell surface. J Virol 70: 3599-3605.
12. Nicot C, et al. (2001) HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells. Blood 98:823-829.
13. Kim SJ, Nair AM, Fernandez S, Mathes L, Lairmore MD (2006) Enhancement of LFA-1- mediated T cell adhesion by human T lymphotropic virus type 1 p12I1. J Immunol 176: 5463-5470.
14. Banerjee P, Feuer G, Barker E (2007) Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cellmediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells. J Virol 81:9707-9717.
15. Johnson JM, et al. (2001) Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein. J Virol 75:6086-6094.
16. Sowinski S, et al. (2008) Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nat Cell Biol 10:211-219.
17. Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH (2004) Nanotubular highways for intercellular organelle transport. Science 303:1007-1010.
18. Watkins SC, Salter RD (2005) Functional connectivity between immune cells mediated by tunneling nanotubules. Immunity 23:309-318.
19. Valeri V, et al. (2010) Requirement of the human T-cell leukemia virus p12 and p30 genes for infectivity of human dendritic cells and Macaques but not rabbits. Blood, 10.1182/blood-2010-05-284141.
20. Astier-Gin T, Portail JP, Lafond F, Guillemain B (1995) Identification of HTLV-I- or HTLV-II-producing cells by cocultivation with BHK-21 cells stably transfected with a LTR-lacZ gene construct. J Virol Methods 51:19-29.
21. Taylor JM, et al. (2009) Novel role for interleukin-2 receptor-Jak signaling in retrovirus transmission. J Virol 83:11467-11476.
22. Derse D, Hill SA, Lloyd PA, Chung Hk, Morse BA (2001) Examining human Tlymphotropic virus type 1 infection and replication by cell-free infection with recombinant virus vectors. J Virol 75:8461-8468.
23. Bukoreshtliev NV, et al. (2009) Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells. FEBS Lett 583:1481-1488.
24. Sherer NM, Mothes W (2008) Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis. Trends Cell Biol 18:414-420.
25. Barnard AL, Igakura T, Tanaka Y, Taylor GP, Bangham CR (2005) Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes. Blood 106:988-995.
26. Nejmeddine M, Barnard AL, Tanaka Y, Taylor GP, Bangham CR (2005) Human Tlymphotropic virus, type 1, tax protein triggers microtubule reorientation in the virological synapse. J Biol Chem 280:29653-29660.
27. Nejmeddine M, et al. (2009) HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse. Blood 114: 1016-1025.
28. Mazurov D, Heidecker G, Derse D (2006) HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane. Virology 346:194-204.
29. Heidecker G, Lloyd PA, Fox K, Nagashima K, Derse D (2004) Late assembly motifs of human T-cell leukemia virus type 1 and their relative roles in particle release. J Virol 78:6636-6648.
30. Ali A, et al. (1993) Dendritic cells infected in vitro with human T cell leukaemia/ lymphoma virus type-1 (HTLV-1); enhanced lymphocytic proliferation and tropical spastic paraparesis. Clin Exp Immunol 94:32-37.
31. Jones KS, Petrow-Sadowski C, Huang YK, Bertolette DC, Ruscetti FW (2008) Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells. Nat Med 14:429-436.
32. Igakura T, et al. (2003) Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science 299:1713-1716.
33. Pais-Correia AM, et al. (2010) Biofilm-like extracellular viral assemblies mediate HTLV- 1 cell-to-cell transmission at virological synapses. Nat Med 16:83-89.
34. Hope TJ (2007) Bridging efficient viral infection. Nat Cell Biol 9:243-244.
35. Gerdes HH, Bukoreshtliev NV, Barroso JF (2007) Tunneling nanotubes: A new route for the exchange of components between animal cells. FEBS Lett 581:2194-2201.
36. Davis DM, Sowinski S (2008) Membrane nanotubes: Dynamic long-distance connections between animal cells. Nat Rev Mol Cell Biol 9:431-436.
37. Rudnicka D, et al. (2009) Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses. J Virol 83:6234-6246.
38. Markham PD, Salahuddin SZ, Macchi B, Robert-Guroff M, Gallo RC (1984) Transformation of different phenotypic types of human bone marrow T-lymphocytes by HTLV-1. Int J Cancer 33:13-17.
39. Fenard D, et al. (2005) Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. J Immunol 175:6050-6057.
40. Thoulouze MI, et al. (2006) Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse. Immunity 24:547-561.
41. Yarchoan R, et al. (1986) Alterations in cytotoxic and helper T cell function after infection of T cell clones with human T cell leukemia virus, type I. J Clin Invest 77: 1466-1473.
42. Cho NH, et al. (2004) Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri. J Exp Med 200:681-687.
43. Xu W, et al. (2009) HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nat Immunol 10: 1008-1017.
44. Hanon E, et al. (2000) Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity 13:657-664.
45. Nagai M, Brennan MB, Sakai JA, Mora CA, Jacobson S (2001) CD8(+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I. Blood 98:1858-1861.
46. Bunn PA, Jr., et al. (1983) Clinical course of retrovirus-associated adult T-cell lymphoma in the United States. N Engl J Med 309:257-264.
47. Gonda MA, Aaronson SA, Ellmore N, Zeve VH, Nagashima K (1976) Ultrastructural studies of surface features of human normal and tumor cells in tissue culture by scanning and transmission electron microscopy. J Natl Cancer Inst 56:245-263.