Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway

British Journal of Haematology

Volumn 136, Issue 3, 2007, Pages 424-432

  Ishikawa, Chie ^a   Matsuda, Takehiro ^a   Okudaira, Taeko ^a   Tomita, Mariko ^a   Kawakami, Hirochika ^a   Tanaka, Yuetsu ^a   Masuda, Masato ^a   Ohshiro, Kazuiku ^b   Ohta, Takao ^a   Mori, Naoki ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b Children's Medical Center   (Japan)

Author keywords

Adult T cell leukaemia; Bisphosphonate; Human T cell leukaemia virus type I; Incadronate; Mevalonate

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; INCADRONIC ACID; MEVALONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE ATROPHY; BONE LESION; CANCER INHIBITION; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HYPERCALCEMIA; LEUKEMIA CELL; LYMPHOID CELL LINE; MALE; MORBIDITY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRENYLATION; PRIORITY JOURNAL; SCID MOUSE; T CELL LEUKEMIA; T LYMPHOCYTE; TUMOR GROWTH; TUMOR VOLUME;

AGED; ANIMALS; ANTIMETABOLITES; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DIPHOSPHONATES; FEMALE; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; JURKAT CELLS; LEUKEMIA, T-CELL; LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED; MALE; MEVALONIC ACID; MICE; MICE, SCID; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 33846008380     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2006.06445.x     Document Type: Article

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