Requirement for Pdx1 in specification of latent endocrine progenitors in zebrafish

BMC Biology

Volumn 9, Issue , 2011, Pages

  Kimmel, Robin A ^a   Onder, Lucas ^b   Wilfinger, Armin ^a   Ellertsdottir, Elin ^c   Meyer, Dirk ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b Kantonsspital St Gallen   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DANIO RERIO; MAMMALIA;

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; HB9 PROTEIN, ZEBRAFISH; HOMEODOMAIN PROTEIN; INSULIN; MESSENGER RNA; MORPHOLINO OLIGONUCLEOTIDE; NERVE PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; NOTCH RECEPTOR; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; ZEBRAFISH PROTEIN;

ANIMAL; ANIMAL EMBRYO; ARTICLE; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL MOTION; DRUG EFFECT; ENDOCRINE SYSTEM; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; MITOSIS; MORPHOGENESIS; MOUSE; PANCREAS ISLET BETA CELL; PATHOLOGY; PRENATAL DEVELOPMENT; STEM CELL; ZEBRA FISH;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY PATTERNING; CELL DIFFERENTIATION; CELL MOVEMENT; EMBRYO, NONMAMMALIAN; ENDOCRINE SYSTEM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; GREEN FLUORESCENT PROTEINS; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; MICE; MITOSIS; MODELS, BIOLOGICAL; MORPHOLINOS; NERVE TISSUE PROTEINS; RECEPTORS, NOTCH; RNA, MESSENGER; STEM CELLS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 80054993971     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/1741-7007-9-75     Document Type: Article

References (49)

1. Guney MA, Gannon M. Pancreas cell fate. Birth Defects Res C Embryo Today 2009, 87:232-248. 10.1002/bdrc.20156, 2755625, 19750517.
2. Solar M, Cardalda C, Houbracken I, Martin M, Maestro MA, De Medts N, Xu X, Grau V, Heimberg H, Bouwens L, Ferrer J. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell 2009, 17:849-860. 10.1016/j.devcel.2009.11.003, 20059954.
3. Hesselson D, Anderson RM, Beinat M, Stainier DY. Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labeling. Proc Natl Acad Sci USA 2009, 106:14896-14901. 10.1073/pnas.0906348106, 2736433, 19706417.
4. Field HA, Dong PD, Beis D, Stainier DY. Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Dev Biol 2003, 261:197-208. 10.1016/S0012-1606(03)00308-7, 12941629.
5. Wang Y, Rovira M, Yusuff S, Parsons MJ. Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing {beta}-cells. Development 2011, 138:609-617. 10.1242/dev.059097, 21208992.
6. Moro E, Gnugge L, Braghetta P, Bortolussi M, Argenton F. Analysis of beta cell proliferation dynamics in zebrafish. Dev Biol 2009, 332:299-308. 10.1016/j.ydbio.2009.05.576, 19500567.
7. Parsons MJ, Pisharath H, Yusuff S, Moore JC, Siekmann AF, Lawson N, Leach SD. Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech Dev 2009, 126:898-912. 10.1016/j.mod.2009.07.002, 19595765.
8. Chen S, Li C, Yuan G, Xie F. Anatomical and histological observation on the pancreas in adult zebrafish. Pancreas 2007, 34:120-125. 10.1097/01.mpa.0000246661.23128.8c, 17198193.
9. Bonal C, Herrera PL. Genes controlling pancreas ontogeny. Int J Dev Biol 2008, 52:823-835. 10.1387/ijdb.072444cb, 18956314.
10. Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn 2011, 240:530-565. 10.1002/dvdy.22584, 21337462.
11. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996, 122:983-995.
12. Ahlgren U, Jonsson J, Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 1996, 122:1409-1416.
13. Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA. The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest 2009, 119:1888-1898. 10.1172/JCI37028, 2701861, 19487809.
14. Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol 2008, 316:74-86. 10.1016/j.ydbio.2008.01.011, 2425677, 18294628.
15. Murtaugh LC. Pancreas and beta-cell development: from the actual to the possible. Development 2007, 134:427-438.
16. Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet 1999, 23:71-75.
17. Li H, Arber S, Jessell TM, Edlund H. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet 1999, 23:67-70.
18. Yee NS, Yusuff S, Pack M. Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Genesis 2001, 30:137-140. 10.1002/gene.1049, 11477692.
19. Lin JW, Biankin AV, Horb ME, Ghosh B, Prasad NB, Yee NS, Pack MA, Leach SD. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev Biol 2004, 270:474-486. 10.1016/j.ydbio.2004.02.023, 15183727.
20. Wendik B, Maier E, Meyer D. Zebrafish mnx genes in endocrine and exocrine pancreas formation. Dev Biol 2004, 268:372-383. 10.1016/j.ydbio.2003.12.026, 15063174.
21. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H. Notch signalling controls pancreatic cell differentiation. Nature 1999, 400:877-881. 10.1038/23716, 10476967.
22. Kim W, Shin YK, Kim BJ, Egan JM. Notch signaling in pancreatic endocrine cell and diabetes. Biochem Biophys Res Commun 2010, 392:247-251. 10.1016/j.bbrc.2009.12.115, 20035712.
23. Zecchin E, Filippi A, Biemar F, Tiso N, Pauls S, Ellertsdottir E, Gnugge L, Bortolussi M, Driever W, Argenton F. Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish. Dev Biol 2007, 301:192-204. 10.1016/j.ydbio.2006.09.041, 17059815.
24. Gradwohl G, Dierich A, LeMeur M, Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 2000, 97:1607-1611. 10.1073/pnas.97.4.1607, 26482, 10677506.
25. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 1997, 11:2323-2334. 10.1101/gad.11.18.2323, 316513, 9308961.
26. Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F. NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor. Dev Dyn 2005, 233:946-953. 10.1002/dvdy.20443, 15906379.
27. Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, Ravassard P, Vermot J, Voz ML, Mellitzer G, Gradwohl G. Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development 2010, 137:203-212. 10.1242/dev.041673, 2799156, 20040487.
28. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 2000, 127:3533-3542.
29. Huang H, Liu N, Lin S. Pdx-1 knockdown reduces insulin promoter activity in zebrafish. Genesis 2001, 30:134-136. 10.1002/gene.1048, 11477691.
30. Obholzer N, Wolfson S, Trapani JG, Mo W, Nechiporuk A, Busch-Nentwich E, Seiler C, Sidi S, Söllner C, Duncan RN, Boehland A, Nicolson T. Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. J Neurosci 2008, 28:2110-2118. 10.1523/JNEUROSCI.5230-07.2008, 18305245.
31. Baird GS, Zacharias DA, Tsien RY. Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci USA 2000, 97:11984-11989. 10.1073/pnas.97.22.11984, 17281, 11050229.
32. Dong PD, Munson CA, Norton W, Crosnier C, Pan X, Gong Z, Neumann CJ, Stainier DY. Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nat Genet 2007, 39:397-402. 10.1038/ng1961, 17259985.
33. Langenberg T, Brand M, Cooper MS. Imaging brain development and organogenesis in zebrafish using immobilized embryonic explants. Dev Dyn 2003, 228:464-474. 10.1002/dvdy.10395, 14579384.
34. Pauls S, Zecchin E, Tiso N, Bortolussi M, Argenton F. Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts. Dev Biol 2007, 304:875-890. 10.1016/j.ydbio.2007.01.024, 17335795.
35. Wan H, Korzh S, Li Z, Mudumana SP, Korzh V, Jiang YJ, Lin S, Gong Z. Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Exp Cell Res 2006, 312:1526-1539. 10.1016/j.yexcr.2006.01.016, 16490192.
36. Pisharath H, Rhee JM, Swanson MA, Leach SD, Parsons MJ. Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mech Dev 2007, 124:218-229. 10.1016/j.mod.2006.11.005, 2583263, 17223324.
37. Kimmel RA, Meyer D. Molecular regulation of pancreas development in zebrafish. Methods Cell Biol 2010, 100:261-280.
38. Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 2008, 314:406-417. 10.1016/j.ydbio.2007.10.038, 2269701, 18155690.
39. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H. beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998, 12:1763-1768. 10.1101/gad.12.12.1763, 316911, 9637677.
40. Hale MA, Kagami H, Shi L, Holland AM, Elsasser HP, Hammer RE, MacDonald RJ. The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. Dev Biol 2005, 286:225-237. 10.1016/j.ydbio.2005.07.026, 16126192.
41. Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev 2006, 20:253-266. 10.1101/gad.1360106, 1356115, 16418487.
42. Ward AB, Warga RM, Prince VE. Origin of the zebrafish endocrine and exocrine pancreas. Dev Dyn 2007, 236:1558-1569. 10.1002/dvdy.21168, 17474119.
43. Chung WS, Stainier DY. Intra-endodermal interactions are required for pancreatic beta cell induction. Dev Cell 2008, 14:582-593. 10.1016/j.devcel.2008.02.012, 2396532, 18410733.
44. Chung WS, Shin CH, Stainier DY. Bmp2 signaling regulates the hepatic versus pancreatic fate decision. Dev Cell 2008, 15:738-748. 10.1016/j.devcel.2008.08.019, 2610857, 19000838.
45. Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 2011, 138:653-665. 10.1242/dev.056499, 21266405.
46. Haas P, Gilmour D. Chemokine signaling mediates self-organizing tissue migration in the zebrafish lateral line. Dev Cell 2006, 10:673-680. 10.1016/j.devcel.2006.02.019, 16678780.
47. Thisse C, Thisse B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc 2008, 3:59-69.
48. Argenton F, Zecchin E, Bortolussi M. Early appearance of pancreatic hormone-expressing cells in the zebrafish embryo. Mech Dev 1999, 87:217-221. 10.1016/S0925-4773(99)00151-3, 10495291.
49. Shin D, Lee Y, Poss KD, Stainier DY. Restriction of hepatic competence by Fgf signaling. Development 2011, 138:1339-1348. 10.1242/dev.054395, 21385764.