NeuroD1 in the endocrine pancreas: Localization and dual function as an activator and repressor

Developmental Dynamics

Volumn 233, Issue 3, 2005, Pages 946-953

  Itkin Ansari, Pamela ^a,d   Marcora, E ^b   Geron, I ^a   Tyrberg, B ^a   Demeterco, C ^a   Hao, E ^a   Padilla, C ^a   Ratineau, C ^c   Leiter, A ^c   Lee, J E ^b   Levine, F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c TUFTS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cell; cell; Differentiation; Insulin; Islet; NeuroD1; Pancreas; PDX 1; Somatostatin

Indexed keywords

GENOMIC DNA; INSULIN; MESSENGER RNA; NEUROGENIC DIFFERENTIATION FACTOR; SOMATOSTATIN; TRANSCRIPTION FACTOR PDX 1;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

AGING; AMYLOID; ANIMALS; ANIMALS, NEWBORN; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; NERVE TISSUE PROTEINS; PANCREAS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SOMATOSTATIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

MUS MUSCULUS;

EID: 20744456269     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.20443     Document Type: Article

References (48)

1. Alpert S, Hanahan D, Teitelman G. 1988. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53:295-308.
2. Beattie GM, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez AD, Bossie S, Mally MI, Levine F, Hayek A. 1999. Sustained proliferation of PDX-1+ cells derived from human islets. Diabetes 48:1013-1019.
3. Berts A, Ball A, Dryselius G, Gylfe E, Hellman B. 1996. Glucose stimulation of somatostatin-producing islet cells involves oscillatory Ca2+ signaling. Endocrinology 137:693-697.
4. Bhathena SJ, Awoke S, Voyles NR, Wilkins SD, Recant L, Oie HK, Gazdar AF. 1984. Insulin, glucagon, and somatostatin secretion by cultured rat islet cell tumor and its clones. Proc Soc Exp Biol Med 175:35-38.
5. Burns JC, Friedmann T, Driever W, Burrascano M, Yee JK. 1993. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and non-mammalian cells [see comments]. Proc Natl Acad Sci U S A 90:8033-6037.
6. Chiang MK, Melton DA. 2003. Single-cell transcript analysis of pancreas development. Dev Cell 4:383-393.
7. Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P. 2003. Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev 17:2591-2603.
8. de Krijger RR, Aanstoot HJ, Kranenburg G, Reinhard M, Visser WJ, Bruining GJ. 1992. The midgestational human fetal pancreas contains cells coexpressing islet hormones. Dev Biol 153:368-375.
9. Dor Y, Brown J, Martinez OI, Melton DA. 2004. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46.
10. Dufayet de la Tour D, Halvorsen T, Demeterco C, Tyrberg B, Itkin-Ansari P, Loy M, Yoo S-J, Hao E, Bossie S, Levine F. 2001. β-cell differentiation from a human pancreatic cell line in vitro and in vivo. Mol Endocrinol 15:476-483.
11. Dumonteil E, Laser B, Constant I, Philippe J. 1998. Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2. J Biol Chem 273:19945-19954.
12. Duvillie B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier JM, Monthioux E, Jami J, Joshi RL, Bucchini D. 1997. Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci USA 94:5137-5140.
13. Engel I, Murre C. 1999. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas. Proc Natl Acad Sci USA 96:996-1001.
14. Fernandes A, King LC, Guz Y, Stein R, Wright CV, Teitelman G. 1997. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138:1750-1762.
15. German MS, Moss LG, Wang J, Rutter WJ. 1992a. The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes. Mol Cell Biol 12:1777-1788.
16. German MS, Wang J, Chadwick RB, Rutter WJ. 1992b. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev 6:2165-2176.
17. Glick E, Leshkowitz D, Walker MD. 2000. Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter. J Biol Chem 275:2199-2204.
18. Gu G, Dubauskaite J, Melton DA. 2002. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457.
19. Guz Y, Nasir I, Teitelman G. 2001. Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 142: 4956-4968.
20. Hawley RG, Lieu FHL, Fong AZC, Hawley TS. 1994. Versatile retroviral vectors for potential use in gene therapy. Gene Ther 1:136-138.
21. Herrera PL. 2002. Denning the cell lineages of the islets of Langerhans using transgenic mice. Int J Dev Biol 46:97-103.
22. Itkin-Ansari P, Demeterco C, Bossie S, de la Tour DD, Beattie GM, Movassat J, Mally MI, Hayek A, Levine F. 2000. PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell line. Mol Endocrinol 14:814-822.
23. Itkin-Ansari P, Geron I, Hao E, Demeterco C, Tyrberg B, Levine F. 2003. Progress towards a transplantable human beta-cell line. Ann N Y Acad Sci 1005:138-147.
24. Jensen J, Serup P, Karlsen C, Nielsen TF, Madsen OD. 1996. mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell- specific homeodomain transcription factor. J Biol Chem 271:18749-18758.
25. Kim SK, Hebrok M. 2001. Intercellular signals regulating pancreas development and function. Genes Dev 15:111-127.
26. Lee JE, Hollenberg SM, Snider L, Turner DL, Lipnick N, Weintraub H. 1995. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836-843.
27. Lukinius A, Ericsson JLE, Grimelius L, Korsgren O. 1992. Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormones. Dev Biol 153:376-385.
28. Macfarlane WM, Shepherd RM, Cosgrove KE, James RF, Dunne MJ, Docherty K. 2000. Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+. Diabetes 49:418-423.
29. Mathis D, Vence L, Benoist C. 2001. beta-Cell death during progression to diabetes. Nature 414:792-798.
30. Miller CP, McGehee Jr. RE, Habener JF. 1994. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 13:1145-1156.
31. Miyata T, Maeda T, Lee JE. 1999. NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev 13:1647-1652.
32. Naya FJ, Stellrecht CMM, Tsai M-J. 1995. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 9:1009-1019.
33. Naya FJ, Huang HP, Qiu Y, Mutoh H, De-Mayo FJ, Leiter AB, Tsai MJ. 1997. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11:2323-2334.
34. Qiu Y, Sharma A, Stein R. 1998. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol 18:2957-2964.
35. Robertson RP, Harmon J, Tran PO, Poitout V. 2004. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53(Suppl 1): S119-S124.
36. Rudnick A, Ling TY, Odagiri H, Rutter WJ, German MS. 1994. Pancreatic beta cells express a diverse set of homeobox genes. Proc Natl Acad Sci U S A 91:12203-12207.
37. Sander M, Neubuser A, Kalamaras J, Ee HC, Martin GR, German MS. 1997. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11:1662-1673.
38. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS. 2000. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127:3533-3542.
39. Serup P, Jensen J, Andersen FG, Forgensen MC, Blume N, Holst JJ, Madsen OD. 1996. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc Natl Acad Sci U S A 93:9015-9020.
40. Shimizu H, Shimizu C, Burns JC. 1994. Detection of novel RNA viruses: morbilliviruses as a model system. Mol Cell Probes 8:209-214.
41. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P. 1997. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature 386:399-402.
42. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. 1998. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125:2213-2221.
43. Teitelman G. 1996. Induction of beta-cell neogenesis by islet injury. Diabetes Metab Rev 12:91-102.
44. Teitelman G, Lee JK. 1987. Cell lineage analysis of pancreatic islet cell development: glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct. Dev Biol 121:454-466.
45. Teitelman G, Alpert S, Polak JM, Martinez A, Hanahan D. 1993. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118:1031-1039.
46. Upchurch BH, Aponte GW, Leiter AB. 1994. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development 120:245-252.
47. Vallejo M, Miller CP, Beckman W, Habener JF. 1995. Repression of somatostatin gene transcription mediated by two promoter silencer elements. Mol Cell Endocrinol 113:61-72.
48. Watada H, Kajimoto Y, Miyagawa J, Hanafusa T, Hamaguchi K, Matsuoka T, Yamamoto K, Matsuzawa Y, Kawamori R, Yamasaki Y. 1996. PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes 45:1826-1831.