Analysis of glomerular VEGF mRNA and protein expression in murine mesangioproliferative glomerulonephritis

Virchows Archiv

Volumn 450, Issue 1, 2007, Pages 81-92

  Haas, Christian S ^c   Câmpean, Valentina ^a   Kuhlmann, Alexander ^a   Dimmler, Arno ^a   Reulbach, Udo ^a   Forster, Christian ^a   Aigner, Thomas ^b   Acker, Till ^d   Plate, Karl ^d   Amann, Kerstin ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

Habu snake venom glomerulonephritis; Laser capture microdissection; Mesangiolysis; Mouse; Real time PCR; VEGF

Indexed keywords

MESSENGER RNA; SNAKE VENOM; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; CONTROL GROUP; CONTROLLED STUDY; DISEASE MODEL; GENE EXPRESSION; GLOMERULUS; GLOMERULUS CAPILLARY; HEALING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY INJURY; LASER CAPTURE MICRODISSECTION; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MICRODISSECTION; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEREOLOGY; TISSUE REPAIR;

ANIMALS; CROTALID VENOMS; DISEASE MODELS, ANIMAL; GLOMERULAR MESANGIUM; GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE; IMMUNOHISTOCHEMISTRY; KIDNEY GLOMERULUS; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33847668352     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-006-0340-0     Document Type: Article

References (44)

1. Alcorta DA, Prakash K, Waga I, Sasai H, Munger W, Jennette JC, Falk RJ (2000) Future molecular approaches to the diagnosis and treatment of glomerular disease. Semin Nephrol 20:20-31
2. Amann K, Nichols C, Tornig J, Schwarz U, Zeier M, Mall G, Ritz E (1996) Effect of ramipril, nifedipine, and moxonidine on glomerular morphology and podocyte structure in experimental renal failure. Nephrol Dial Transplant 11:1003-1011
3. Anders HJ, Vielhauer V, Kretzler M, Cohen CD, Segerer S, Luckow B, Weller L, Grone HJ, Schlondorff D (2001) Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. J Am Soc Nephrol 12:919-931
4. Barnes JL, Hevey KA, Hastings RR, Bocanegra RA (1994) Mesangial cell migration precedes proliferation in Habu snake venom-induced glomerular injury. Lab Invest 70:460-467
5. Basile DP, Donohoe D, Roethe K, Osborn JL (2001) Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am J Physiol Renal Physiol 281:F887-F899
6. Bohle RM, Hartmann E, Kinfe T, Ermert L, Seeger W, Fink L (2000) Cell type-specific mRNA quantitation in non-neoplastic tissues after laser-assisted cell picking. Pathobiology 68:191-195
7. Bradfield JW, Cattell V, Smith J (1977) The mesangial cell in glomerulonephritis. II. Mesangial proliferation caused by Habu snake venom in the rat. Lab Invest 36:487-492
8. Cattell V, Bradfield JW (1977) Focal mesangial proliferative glomerulonephritis in the rat caused by habu snake venom. A morphologic study. Am J Pathol 87:511-524
9. Cooper ME, Vranes D, Youssef S, Stacker SA, Cox AJ, Rizkalla B, Casley DJ, Bach LA, Kelly DJ, Gilbert RE (1999) Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes. Diabetes 48:2229-2239
10. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-991
11. De Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH (2001) Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes. J Am Soc Nephrol 12:993-1000
12. Dimmler A, Haas CS, Cho S, Hattler M, Forster C, Peters H, Schocklmann HO, Amann K (2003) Laser capture microdissection and real-time PCR for analysis of glomerular endothelin-1 gene expression in mesangiolysis of rat anti-Thy 1.1 and murine Habu Snake Venom glomerulonephritis. Diagn Mol Pathol 12:108-117
13. el Nahas AM, Bassett AH, Cope GH, Le Carpentier JE (1991) Role of growth hormone in the development of experimental renal scarring. Kidney Int 40:29-34
14. Esposito C, Striker LJ, Patel A, Peten E, Liu ZH, Sakai H, Striker GE (1996) Molecular analysis of glomerular diseases in renal biopsies: initial results of a collaborative international study. The International Study Group for Molecular Study of Kidney Biopsies. Proc Assoc Am Physicians 108:209-217
15. Ferrara N, Houck K, Jakeman L, Leung DW (1992) Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 13:18-32
16. Fink L, Seeger W, Ermert L, Hanze J, Stahl U, Grimminger F, Kummer W, Bohle RM (1998) Real-time quantitative RT-PCR after laser-assisted cell picking. Nat Med 4:1329-1333
17. Flyvbjerg A, Dagnaes-Hansen F, De Vriese AS, Schrijvers BF, Tilton RG, Rasch R (2002) Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes 51:3090-3094
18. Goumenos DS, Brown CB, Shortland J, el Nahas AM (1994) Myofibroblasts, predictors of progression of mesangial IgA nephropathy? Nephrol Dial Transplant 9:1418-1425
19. Hara A, Wada T, Furuichi K, Sakai N, Kawachi H, Shimizu F, Shibuya M, Matsushima K, Yokoyama H, Egashira K, Kaneko S (2006) Blockade of VEGF accelerates proteinuria, via decrease in nephrin expression in rat crescentic glomerulonephritis. Kidney Int 69:1986-1995
20. Iijima K, Yoshikawa N, Connolly DT, Nakamura H (1993) Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor. Kidney Int 44:959-966
21. Inoue K, Sakurada Y, Murakami M, Shirota M, Shirota K (2003) Detection of gene expression of vascular endothelial growth factor and flk-1 in the renal glomeruli of the normal rat kidney using the laser microdissection system. Virchows Arch 442:159-162
22. Iruela-Arispe L, Gordon K, Hugo C, Duijvestijn AM, Claffey KP, Reilly M, Couser WG, Alpers CE, Johnson RJ (1995) Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis. Am J Pathol 147:1715-1727
23. Janssen U, Eitner F, Kunter U, Ostendorf T, Wolf G, Chaponnier C, Gabbiani G, Kerjaschki D, Floege J (2003) Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis. Nephron Exp Nephrol 93:e158-e167
24. Kelly DJ, Hepper C, Wu LL, Cox AJ, Gilbert RE (2003) Vascular endothelial growth factor expression and glomerular endothelial cell loss in the remnant kidney model. Nephrol Dial Transplant 18:1286-1292
25. Kim YG, Suga SI, Kang DH, Jefferson JA, Mazzali M, Gordon KL, Matsui K, Breiteneder-Geleff S, Shankland SJ, Hughes J, Kerjaschki D, Schreiner GF, Johnson RJ (2000) Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy. Kidney Int 58:2390-2399
26. Kitamura H, Sugisaki Y, Yamanaka N (1995) Endothelial regeneration during the repair process following Habu-snake venom induced glomerular injury. Virchows Arch 427:195-204
27. Kohda Y, Murakami H, Moe OW, Star RA (2000) Analysis of segmental renal gene expression by laser capture microdissection. Kidney Int 57:321-331
28. Kretzler M, Schroppel B, Merkle M, Huber S, Mundel P, Horster M, Schlondorff D (1998) Detection of multiple vascular endothelial growth factor splice isoforms in single glomerular podocytes. Kidney Int Suppl 67:S159-S161
29. Kriz W (2002) Podocyte is the major culprit accounting for the progression of chronic renal disease. Microsc Res Tech 57:189-195
30. Masuda Y, Shimizu A, Mori T, Ishiwata T, Kitamura H, Ohashi R, Ishizaki M, Asano G, Sugisaki Y, Yamanaka N (2001) Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis. Am J Pathol 159:599-608
31. Nakao N, Hiraiwa N, Yoshiki A, Ike F, Kusakabe M (1998) Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture. Am J Pathol 152:1237-1245
32. Noguchi K, Yoshikawa N, Ito-Kariya S, Inoue Y, Hayashi Y, Ito H, Nakamura H, Iijima K (1998) Activated mesangial cells produce vascular permeability factor in early-stage mesangial proliferative glomerulonephritis. J Am Soc Nephrol 9:1815-1825
33. Ostendorf T, Kunter U, Eitner F, Loos A, Regele H, Kerjaschki D, Henninger DD, Janjic N, Floege J (1999) VEGF(165) mediates glomerular endothelial repair. J Clin Invest 104:913-923
34. Ostendorf T, Van Roeyen C, Westenfeld R, Gawlik A, Kitahara M, De Heer E, Kerjaschki D, Floege J, Ketteler M (2004) Inducible nitric oxide synthase-derived nitric oxide promotes glomerular angiogenesis via upregulation of vascular endothelial growth factor receptors. J Am Soc Nephrol 15:2307-2319
35. Peti-Peterdi J (2005) Confocal imaging and function of the juxtaglomerular apparatus. Curr Opin Nephrol Hypertens 14:53-57
36. Shimizu A, Masuda Y, Kitamura H, Ishizaki M, Sugisaki Y, Yamanaka N (1998) Recovery of damaged glomerular capillary network with endothelial cell apoptosis in experimental proliferative glomerulonephritis. Nephron 79:206-214
37. Simon M, Grone HJ, Johren O, Kullmer J, Plate KH, Risau W, Fuchs E (1995) Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney. Am J Physiol 268:F240-F250
38. Tanji N, Ross MD, Cara A, Markowitz GS, Klotman PE, D'Agati VD (2001) Effect of tissue processing on the ability to recover nucleic acid from specific renal tissue compartments by laser capture microdissection. Exp Nephrol 9:229-234
39. Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187:1579-1586
40. Trogan E, Choudhury RP, Dansky HM, Rong JX, Breslow JL, Fisher EA (2002) Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice. Proc Natl Acad Sci USA 99:2234-2239
41. Tsuchida K, Makita Z, Yamagishi S, Atsumi T, Miyoshi H, Obara S, Ishida M, Ishikawa S, Yasumura K, Koike T (1999) Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195. Diabetologia 42:579-588
42. Uchida K, Uchida S, Nitta K, Yumura W, Marumo F, Nihei H (1994) Glomerular endothelial cells in culture express and secrete vascular endothelial growth factor. Am J Physiol 266:F81-F88
43. Wada Y, Morioka T, Oyanagi-Tanaka Y, Yao J, Suzuki Y, Gejyo F, Arakawa M, Oite T (2002) Impairment of vascular regeneration precedes progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis. Kidney Int 61:432-443
44. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J (2000) Vascular-specific growth factors and blood vessel formation. Nature 407:242-248