Effects of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) on haemodynamics and permselectivity of the isolated perfused rat kidney

Nephrology Dialysis Transplantation

Volumn 13, Issue 4, 1998, Pages 875-885

  Klanke, Bernd ^a   Simon, Matthias ^b   Röckl, Wolfgang ^c   Weich, Herbert A ^c   Stolte, Hilmar ^a   Gröne, Hermann Josef ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Endothelium dependent vasodilatation; Endothelium derived relaxing factor; Glomerular permeability; N(W) nitro L arginine; Vascular endothelial growth factor; Vascular permeability factor

Indexed keywords

ALBUMIN; DICLOFENAC; ENDOTHELIUM DERIVED RELAXING FACTOR; MITOGENIC AGENT; N 5501; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; PROSTAGLANDIN SYNTHASE INHIBITOR; RECOMBINANT VASCULOTROPIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL TISSUE; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; GLUCOSURIA; HEMODYNAMICS; HYPOXIA; ISOLATED KIDNEY; KIDNEY ARTERY; KIDNEY BLOOD VESSEL; KIDNEY EPITHELIUM; KIDNEY PERFUSION; MALE; NONHUMAN; OXYGEN CONSUMPTION; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SODIUM EXCRETION; URINARY EXCRETION;

ANIMALS; ENDOTHELIAL GROWTH FACTORS; HEMODYNAMIC PROCESSES; HUMANS; KIDNEY; LYMPHOKINES; MALE; OXYGEN CONSUMPTION; PERFUSION; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SODIUM; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0031950215     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/13.4.875     Document Type: Article

References (39)

1. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161: 851-858
2. Conn G, Bayne ML, Soderman DD et al. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci USA 1990; 87: 2628-2632
3. Keck PJ, Hauser SD, Krivi G et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989; 246: 1309-1312
4. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-1309
5. Tischer E, Mitchell R, Hartman T et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991; 266: 11947-11954
6. Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocrinol Rev 1992; 13:18-32
7. Sugihara T, Kaul SC, Mitsui Y, Wadhwa R. Enhanced expression of multiple forms of VEGF is associated with spontaneous immortalization of murine fibroblasts. Biochim Biophys Acta 1994; 1224: 365 370
8. Fava RA, Olsen NJ, Spencer-Green G et al. Vascular permeability factor endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue J Exp Med 1994; 180: 341-346
9. Iijima K, Yoshikawa N, Connolly DT, Nakamura H. Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor. Kidney Int 1993; 44: 959-966
10. Brown LF, Berse B, Tognazzi K et al. Vascular permeability factor mRNA and protein expression in human kidney. Kidney Int 1992; 42: 1457-1461
11. Simon M, Gröne H-J, Jöhren O et al. Expression of vascular endothelial growth factor and its recept in human renal ontogenesis and in adult kidney. Am J Physiol 1995; 268: F240-F250
12. chida K, Uchida S, Nitta K, Yumura W, Marumo F, Nihei H. Glomerular endothelial cells in culture express and secrete vascular endothelial growth factor. Am J Physiol 1994; 266: F81-F88
13. Senger DR. Molecular framework for angiogenesis. A complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines. Am J Pathol 1996; 149: 1-7
14. Peters KG, De Vries C, Williams LT. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci USA 1993; 90: 8915-8919
15. Yamane A, Seetharam L, Yamaguchi S et al. A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-I). Oncogene 1994; 9: 2683-2690
16. Matthews W, Jordan CT, Gavin M, Jenkins NA, Copeland NG, Lemischka IR. A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci USA 1991; 88: 9026-9030
17. Shen H, Clauss M, Ryan J et al. Characterization of vascular permeability factor vascular endothelial growth factor receptors on mononuclear phagocytes. Blood 1993; 81: 2767-2773
18. Connolly DT. Vascular permeability factor: a unique regulator of blood vessel function. J Cell Biochem 1991; 47: 219-223
19. Roberts WG, Palade GE. Increased microvascular permeability an endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 1995; 108: 2369-2379
20. Pepper MS, Ferrara N, Orci L, Montesano R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 1991; 181: 902-906
21. Ryan GB, Karnovsky MJ. Distribution of endogenous albumin in the rat glomerulus. Role of hemodynamic factors in glomerular barrier function Kidney Int 1976; 9: 36-45
22. Ku DD, Zaleski JK, Liu S, Brock TA. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am J Physiol 1993; 265: H586-H592
23. Radermacher J, Klanke B, Schurek HJ, Stolte H, Frölich JC. Importance of NO/EDRF for glomerular and tubular function: studies in the isolated perfused rat kidney. Kidney Int 1992; 41: 1549-1559
24. Schurek HJ, Alt JM. Effect of albumin on the function of perfused rat kidney. Am J Physiol 1981; 240: F569-F576
25. Schmidt FH. Die enzymatische Bestimmung von Glucose und Fructose nebeneinander. Klin Wochenschr 1961; 39: 1244-1247
26. Fiebich BL, Jager B, Schöllmann C et al. Synthesis and assembly of functional active human vascular endothelial growth factor homodimers in insect cells. Eur J Biochem 1993; 211: 19-26
27. Radermacher J, Förstermann U, Frölich JC. Endothelium-derived relaxing factor influences renal vascular resistance. Am J Physiol 1990; 259: F9-F17
28. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 1976; 72: 248-254
29. 2+ and von Willebrand factor release in human endothelial cells. Am J Pathol 1991; 138: 213-221
30. Vanhoutte PM, Miller VM. Alpha 2-adrenoceptors and endothelium-derived relaxing factor. Am J Med 1989; 87[Suppl. 3C]: 1S-5S
31. Suga S, Nakao K, Itoh H et al. Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-β. Possible existence of 'Vascular natriuretic peptide system'. J Clin Invest 1992; 90: 1145-1149
32. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983; 219: 983-985
33. Connolly DT, Olander JV, Heuvelman D et al. Human vascular permeability factor. Isolation from U937 cells. J Biol Chem 1989; 264: 20017-20024
34. Kanwar YS. Biology of disease: biophysiology of glomerular filtration and proteinuria. Lab Invest 1984; 51: 7-21
35. Farquhar MG, Wissig SL, Palade GE. Glomerular permeability. I. Ferritin transfer across the normal glomeriular capillary wall. J Exp Med 1961; 113: 47-66
36. Sonnenburg-Hatzopoulos C, Assel E, Schurek HJ, Stolte H. Glomerular albumin leakage and morphology after neutralization of polyanions. II. Discrepancy of protamine induced albuminuria and fine structure of the glomerular filtration barrier. J Submicrosc Cytol 1984; 16: 741-751
37. Schurek HJ. Mechanisms of glomerular proteinuria and hematuria. Kidney Int. 1994; [Suppl. 47] 46: S12 S16
38. Schurek HJ, Neumann KH, Flohr H, Zeh M, Slolte H. The physiological and pathophysiological basis of glomerular permeability for plasma proteins and erythrocytes. Eur J Clin Chem Clin Biochem 1992; 30: 627-633
39. Larsson L, Maunsbach AB. The ultrastructural development of the glomerular filtration barrier in the rat kidney: a morphometric analysis. J Ultrastruct Res 1980; 72: 392-406