Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease

American Journal of Nephrology

Volumn 28, Issue 6, 2008, Pages 998-1006

  Heyman, Samuel N ^a,d   Khamaisi, Mogher ^a   Rosen, Seymour ^b   Rosenberger, Christian ^c  

^a HEBREW UNIVERSITY   (Israel)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Chronic kidney disease; Hypoxia, renal parenchymal; Oxygenation, renal tissue

Indexed keywords

ERYTHROPOIETIN; HEME OXYGENASE; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PIMONIDAZOLE;

AGING; ANEMIA; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DISEASE COURSE; GENE EXPRESSION; GLOMERULOPATHY; HUMAN; HYPERTENSION; HYPOXEMIA; IMMUNOHISTOCHEMISTRY; INTERSTITIAL NEPHRITIS; KIDNEY HYPERTROPHY; KIDNEY MEDULLA; KIDNEY PARENCHYMA; KIDNEY PERFUSION; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSTRUCTIVE UROPATHY; OXYGEN ELECTRODE; OXYGEN TENSION; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; RENAL PROTECTION; RENOVASCULAR DISEASE; REVIEW; TISSUE DISTRIBUTION; TISSUE OXYGENATION; TISSUE REACTION;

ANOXIA; DISEASE PROGRESSION; GLOMERULAR FILTRATION RATE; HUMANS; ISCHEMIA; KIDNEY; KIDNEY FAILURE, CHRONIC; MODELS, BIOLOGICAL; OXYGEN; OXYGEN CONSUMPTION; RECEPTOR, ENDOTHELIN B;

EID: 47149092668     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000146075     Document Type: Review

References (63)

1. Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 1982;307:652-659.
2. Dunn BR, Anderson S, Brenner BM: The hemodynamic basis of progressive renal disease. Semin Nephrol 1986;6:122-138.
3. Schainuck LI, Striker GE, Cutler RE, Benditt EP: Structural-functional correlations in renal disease. II. The correlations. Hum Pathol 1970;1:631-641.
4. Remuzzi G, Bertani T: Pathophysiology of progressive nephropathies. N Engl J Med 1998;339:1448-1456.
5. Parmar MS: Strategies to Retard Progression of Chronic Kidney Disease. MKSAP in Nephrology and Hypertension, ed 2. 1998. http://www.uninet.edu/cin2002/ html/conf/parmar/parmar.html.
6. Fine LG, Bandyopadhay D, Norman JT: Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney Int 2000;57(suppl 75):S22-S26.
7. Brezis M, Rosen S: Hypoxia of the renal medulla - its implications for disease. N Engl J Med 1995;332:647-655.
8. O'Connor PM: Renal oxygen delivery: matching delivery to metabolic demand. Clin Exp Pharmacol Physiol 2006;33:961-967.
9. Rosenberger C, Rosen S, Heyman SN: Renal parenchymal oxygenation and hypoxia adaptation in acute kidney injury. Clin Exp Pharmacol Physiol 2006;33:980-988.
10. 2 and renal oxygen usage in the hypertensive rat kidney. Kidney Int 2001;59:230-237.
11. Heyman SN, Brezis M, Epstein FH, Spokes K, Silva P, Rosen S: Early renal medullary hypoxic injury from radiocontrast and indomethacin. Kidney Int 1991;40:632-642.
12. Agmon Y, Brezis M: Effects of nonsteroidal anti-inflammatory drugs upon intrarenal blood flow: selective medullary hypoperfusion. Exp Nephrol 1993;1:357-363.
13. Haase VH: Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol 2006;291:F271-F281.
14. Maxwell P: HIF-1: an oxygen response system with special relevance to the kidney. J Am Soc Nephrol 2003;14:2712-2722.
15. Rosenberger C, Rosen S, Heyman S: Current understanding of HIF in renal disease. Kidney Blood Press Res 2005;28:325-340.
16. Bachmann S, Le Hir M, Eckardt KU: Colocalization of erythropoietin mRNA and ecto-5′-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin. J Histochem Cytochem 1993;41:335-341.
17. Rosenberger C, Mandriota S, Jurgensen JS, Wiesener MS, Horstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, Eckardt KU: Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 2002;13:1721-1732.
18. Rosenberger C, Griethe W, Gruber G, Wiesener MS, Frei U, Bachmann S, Eckardt KU: Cellular responses to hypoxia after renal segmental infarction. Kidney Int 2003;64:874-886.
19. Rosenberger C, Heyman SN, Rosen S, Shina A, Gruber G, Goldfarb M, Griethe W, Frei U, Bachmann S, Eckardt KU: Up-regulation of HIF in experimental acute renal failure: Evidence for a protective transcriptional response to hypoxia. Kidney Int 2005;67:531-542.
20. Rosenberger C, Goldfarb M, Shina A, Bachmann S, Frei U, Eckardt KU, Schrader T, Rosen S, Heyman SN: Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transpl 2008;23:1135-1143.
21. Manotham K, Ongvilawan B, Urusopone P, Chetsurakram S, Tanamai J, Limkuansuwan P, Tungasanga K, Aiam-Ong S: Intrarenal hypoxia in CKD patients, a BOLD MRI study. J Am Soc Nephrol 2006;17:164A.
22. 2 indicating a novel, potentially renoprotective action. Nephron Physiol 2003;94:p39-p46.
23. Textor SC, Glockner JF, Lerman LO, Misra S, McKusick MA, Riederer SJ, Grande JP, Gomez I, Romero JC: The use of magnetic resonance to evaluate tissue oxygenation in renal artery stenosis. J Am Soc Nephrol 2008;19:780-788.
24. Basile DP, Donohoe D, Roethe K, Osborn JL: Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am J Physiol Renal Physiol 2001;281:F887-F899.
25. Matsumoto M, Tanaka T, Yamamoto T, Noiri E, Miyata T, Inagi R, Fujita T, Nangaku M: Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis J Am Soc Nephrol 2004;15:1574-1581.
26. Ohashi R, Kitamura H, Yamanaka N: Peritubular capillary injury during the progression of experimental glomerulonephritis in rats. J Am Soc Nephrol 2000;11:47-56.
27. Manotham K, Tanaka T, Matsumoto M, Ohse T, Miyata T, Inagi R, Kurokawa K, Fujita T, Nangaku M: Evidence of tubular hypoxia in the early phase of the remnant kidney model. J Am Soc Nephrol 2004;15:1277-1288.
28. Goldfarb M, Rosenberger C, Abassi Z, Shina A, Zilbersat F, Eckhardt KU, Rosen S, Heyman SN: Acute-on-chronic renal failure in the rat: functional compensation and hypoxia tolerance. Am J Nephrol 2006;26:22-33.
29. Kairaitis LK, Wang Y, Gassman M, Tay YC, Harris DC: HIF-1a expression follows microvascular loss in advanced murine adriamycin nephrosis. Am J Physiol Renal Physiol 2005;288:F198-F206.
30. Zhong Z, Arteel GE, Connor HD, Yin M, Frankenberg MV, Stachlewitz RF, Raleigh JA, Mason RP, Thurman RG: Cyclosporin A increases hypoxia and free radical production by rat kidneys: prevention by dietary glycine. Am J Physiol 1998;275:F595-F604.
31. Yuan H-T, Li X-Z, Pitera JE, Long DA, Woolf AS: Peritubular capillary loss after mouse acute nephrotoxicity correlates with downregulation of vascular endothelial growth factor A and hypoxia-inducible factor-1a. Am J Pathol 2003;163:2289-2301.
32. Epstein FH, Prasad P: Effects of furosemide on medullary oxygenation in younger and older subjects. Kidney Int 2000;57:2080-2083.
33. Tanaka T, Kato H, Kojima I, Ohse T, Son D, Tawakami T, Yatagawa T, Inagi R, Fujita T, Nangaku M: Hypoxia and expression of hypoxia-inducible factor in the aging kidney. J Gerontol A Biol Sci Med Sci 2006;61:795-805.
34. Rathaus M, Greenfeld Z, Podjarny E, Brezis M, Bernheim J: Sodium loading and renal prostaglandins in old rats. Prostaglandins Leukot Essent Fatty Acids 1993;49:815-819.
35. Baylis C: Nitric oxide deficiency in chronic kidney disease. Am J Physiol Renal Physiol 2008;294:F1-F9.
36. Adler S, Huang H, Wolin MS, Kaminski PM: Oxidant stress leads to impaired regulation of renal cortical oxygen consumption by nitric oxide in the aging kidney. J Am Soc Nephrol 2004;15:52-60.
37. Palm F, Cederberg J, Hansell P, Liss P, Carlsson PO: Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension. Diabetologia 2003;46:1153-1160.
38. Ries M, Basseau F, Tyndal B, Jones R, Deminiere C, Catargi B, Combe C, Moonen CW, Grenier N: Renal diffusion and BOLD MRI in experimental diabetic nephropathy. Blood oxygen leveled pendent. J Magn Reson Imaging 2003;17:104-113.
39. Epstein FH, Veves A, Prasad PV: Effect of diabetes on renal medullary oxygenation during water diuresis. Diabetes Care 2002;25:575-578.
40. Rosenberger C, Khamaisi M, Abassi Z, Weksler-Zengen S, Goldfarb M, Shilo V, Shina A, Zilbertrest F, Eckhardt KW, Rosen S, Heyman SN: Adaptation to hypoxia in the diabetic rat kidney. Kidney Int 2008;73:34-42.
41. Katavetin P, Miyata T, Inagi R, Tanaka T, Sassa R, Ingelfinger JR, Fujita T, Nangaku M: High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway. J Am Soc Nephrol 2006;17:1405-1413.
42. Palm F: Intrarenal oxygen in diabetes and a possible link to diabetic nephropathy. Clin Exp Pharmacol Physiol 2006;33:997-1001.
43. Palm F, Friederich M, Carlsson PO, Hansell P, Teerlink T, Liss P: Reduced nitric oxide in diabetic kidneys due to increased hepatic arginine metabolism: implications for renomedullary oxygen availability. Am J Physiol Renal Physiol 2008;294:F30-F37.
44. Welch WJ: Intrarenal oxygen and hypertension. Clin Exp Pharmacol Physiol 2006;33:1002-1005.
45. Stillman LE, Brezis M, Heyman SN, Epstein FH, Spokes K, Rosen S: Effects of salt depletion on the kidney: changes in medullary oxygenation and thick ascending limb size. J Am Soc Nephrol 1994;4:1538-1545.
46. Rosenberger C, Pratschke J, Rudolph B, Rosen S, Heyman SN, Babel N, Schindler R, Eckhardt KW, Frei U, Reinke P: Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies. J Am Soc Nephrol 2007;18:343-351.
47. Sadowski EA, Fain SB, Alford SK, Korosec FR, Fine J, Muehrer R, Djamali A, Hofmann RM, Becker BN, Grist TM: Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experience. Radiology 2005;236:911-919.
48. 2 during acute normovolemic hemodilution. Am J Physiol Renal Physiol 2007;292:F796-F803.
49. Pedersen M, Dissing TH, Morkenborg J, Stodkilde-Jorgensen H, Hansen LH, Pedersen LB, Grenier N, Frokiaer J: Validation of quantitative BOLD MRI measurements in kidney: application to unilateral ureteral obstruction. Kidney Int 2005;67:2305-2312.
50. Nangaku M: Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 2006;17:17-25.
51. Norman JT, Fine LG: Intrarenal oxygenation in chronic renal failure. Clin Exp Pharmacol Physiol 2006;33:989-996.
52. Rosenberger C, Goldfarb M, Khamaisi M, Shina A, Shilo V, Rosen S, Heyman SN: Acute kidney injury in the diabetic rat: studies in the isolated perfused and intact kidney. Am J Nephrol 2008;28:831-839.
53. Melin J, Hellberg O, Fellstrom B: Hyperglycaemia and renal ischaemia-reperfusion injury. Nephrol Dial Transplant 2003;18:460-462.
54. Rosenberger C, Shina A, Rosen S, Goldfarb M, Eckardt K, Heyman SN: Hypoxia inducible factors and tubular cell survival in isolated perfused kidneys. Kidney Int 2006;70:60-70.
55. Doi K, Noiri E, Nakao A, Fujita T, Kobayashi S, Tokunaga K: Functional polymorphisms in the vascular endothelial growth factor gene are associated with development of end-stage renal disease in males. J Am Soc Nephrol 2006;17:823-830.
56. Khamaisi M, Raz I, Shilo V, Shina A, Rosenberger C, Dahan R, Abassi Z, Meidan R, Lecht S, Heyman SN: Diabetes and radiocontrast media increase endothelin converting enzyme-1 in the kidney. Kidney Int 2008;74:91-100.
57. Gurbanov K, Rubinstein I, Hoffman A, Abassi Z, Better O, Winaver J: Differential regulation of renal regional blood flow by endothelin-1. Am J Physiol 1996;271:F1166-F1172.
58. Izuhara Y, Nangaku M, Inagi R, Tominaga N, Aizawa T, Kurokawa K, van Ypersele de Strihou C, Miyata T: Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering. J Am Soc Nephrol 2005;16:3631-3641.
59. Rüster C, Wolf G: Renin-angiotensin-aldosterone system and progression of renal disease. J Am Soc Nephrol 2006;17:2985-2991.
60. Gouva C, Nikolopoulos P, Ioannidis JP, Siamopoulos KC: Treating anemia early in renal failure patients slows the decline of renal function: a randomized controlled trial. Kidney Int 2004;66:753-760.
61. Bahlmann FH, Song R, Boehm SM, et al: Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure. Circulation 2004;110:1006-1012.
62. Bernhardt W, Câmpean V, Kany S, Jürgensen JS, Weidemann A, Warnecke C, Arend M, Klaus S, Günzler V, Amann K, Willam C, Wiesener M, Eckardt KU: Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol 2006;17:1970-1978.
63. Juillard L, Lerman LO, Kruger DG, Haas JA, Rucker BC, Polzin JA, Riederer SJ, Romero JC: Blood oxygen level-dependent measurement of acute intra-renal ischemia. Kidney Int 2004;65:944-950.