Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets

Brain Research

Volumn 1421, Issue , 2011, Pages 100-109

  Zhao, Yuming ^a   Dou, Juan ^c,f   Luo, Jialie ^b   Li, Wenming ^b,f   Chan, Hugh H N ^a   Cui, Wei ^b   Zhang, Huan ^b   Han, Renwen ^b   Carlier, Paul R ^d   Zhang, Xuejun ^e   Han, Yifan ^a,b  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^c SUN YAT SEN UNIVERSITY   (China)

^d VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^e INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bis(12) hupyridone; Ischemia; Neuroprotectant; NMDA receptor; Stroke

Indexed keywords

BIS(12) HUPYRIDONE; CHOLINESTERASE INHIBITOR; DIMER; DIZOCILPINE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING SITE; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; EXCITOTOXICITY; GRANULE CELL; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINESTERASE; ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CEREBELLUM; DNA FRAGMENTATION; ENZYME INHIBITORS; IN SITU NICK-END LABELING; MALE; NEURONS; NEUROPROTECTIVE AGENTS; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

RATTUS;

EID: 80054969251     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.09.014     Document Type: Article

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