Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia

Neuroscience Letters

Volumn 439, Issue 2, 2008, Pages 160-164

  Zhao, Yuming ^a   Li, Wenming ^a,b   Chow, Peter C Y ^a   Lau, Dickson T K ^a   Lee, Nelson T K ^a   Pang, Yuanping ^c   Zhang, Xuejun ^d   Wang, Xiaoliang ^e   Han, Yifan ^a,b  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^c MAYO CLINIC   (United States)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^e INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Bis(7) tacrine; Cerebral ischemia; Memantine; Multiple targets; Stroke

Indexed keywords

BIS(7)TACRINE; DIMER; MEMANTINE; TACRINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ISCHEMIC ATTACK, TRANSIENT; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; TACRINE; TIME FACTORS;

EID: 44649178199     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.007     Document Type: Article

References (25)

1. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., and Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17 (1986) 472-476
2. Culmsee C., Junker V., Kremers W., Thal S., Plesnila N., and Krieglstein J. Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol. Stroke 35 (2004) 1197-1202
3. Dogan A., Eras M.A., Rao V.L., and Dempsey R.J. Protective effects of memantine against ischemia-reperfusion injury in spontaneously hypertensive rats. Acta Neurochir. (Wien) 141 (1999) 1107-1113
4. Fisher M. Characterizing the target of acute stroke therapy. Stroke 28 (1997) 866-872
5. Fu H.J., Li W.M., Liu Y.L., Lao Y.Z., Liu W., Chen C., Yu H., Lee N.T.K., Chang D.C., Li P., Pang Y.P., Tsim W.K., Li M.T., and Han Y.F. Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. J. Proteome Res. 6 (2007) 2435-2446
6. Fu H.J., Li W.M., Lao Y.Z., Luo J.L., Lee N.T., Kan K.K., Tsang H.W., Tsim K.W., Pang Y.P., Li Z.W., Chang D.C., Li M.T., and Han Y.F. Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. J. Neurochem. 98 (2006) 1400-1410
7. Giovannelli L., Cozzi A., Guarnieri I., Dolara P., and Moroni F. Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors. J. Cereb. Blood Flow Metab. 22 (2002) 697-704
8. Gorgulu A., Kins T., Cobanoglu S., Unal F., Izgi N.I., Yanik B., and Kucuk M. Reduction of edema and infarction by memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat. Acta Neurochir. (Wien) 142 (2000) 1287-1292
9. Green R., and Shuaib A. Therapeutic strategies for the treatment of stroke. Drug Discov. Today 11 (2006) 681-693
10. Hong K.W., Kim K.Y., Lee J.H., Shin H.Y., Kwak Y.G., Kim S.O., Lim H., and Yoo S.E. Neuroprotective effect of (2S,3S,4R)-N-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2Hbenzopyran-4-yl)-N-benzylguanidine (KR-31378), a benzopyran analog, against focal ischemic brain damage in rats. J. Pharmacol. Exp. Ther. 301 (2002) 210-216
11. Li L.L., Sun L.N., Zhou H.Y., Li Z.B., and Wang X.L. Selective alteration of expression of Na(+)/Ca(2+) exchanger isoforms after transient focal cerebral ischemia in rats. Neurosci. Lett. 404 (2006) 249-253
12. Li W.M., Xue J., Niu C.Y., Fu H.J., Lam S.C., Luo J.L., Chan H.N., Xue H.G., Kan K.W., Lee T.K., Li C.Y., Pang Y.P., Li M.T., Tsim W.K., Jiang H.L., Chen K.X., Li X.Y., and Han Y.F. Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-d-aspartate receptors and neuronal nitric-oxide synthase. Mol. Pharmacol. 71 (2007) 1258-1267
13. Li W.M., Lee N.T., Fu H.J., Kan K.K., Pang Y.P., Li M.T., Tsim K.W., Li X., and Han Y.F. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport 17 (2006) 471-474
14. Li W.M., Pi R.B., Chan H.H., Fu H.J., Lee N.T., Tsang H.W., Pu Y., Chang D.C., Li C.Y., Luo J.L., Xiong K.M., Li Z.W., Xue H., Carilier P.R., Pang Y.P., Tsim W.K., Li M.T., and Han Y.H. Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-d-aspartate receptors. J. Biol. Chem. 280 (2005) 18179-18188
15. Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature (London) 430 (2004) 631-639
16. Pang Y.P., Quiram P., Jelacic T., Hong F., and Brimijoin S. Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease. J. Biol. Chem. 271 (1996) 23646-23649
17. Serteser M., Ozben T., Gumuslu S., Balkan S., and Balkan E. The effects of NMDA receptor antagonist MK-801 on lipid peroxidation during focal cerebral ischemia in rats. Neuropsychopharmacol. Biol. Psychiat. 26 (2002) 871-877
18. Stieg P.E., Sathi S., Warach S., Le D.A., and Lipton S.A. Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat. Eur. J. Pharmacol. 375 (1999) 115-120
19. Stroke Therapy Academic Industry Roundtable (STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 30 (1999) 2752-2758
20. Wu D.C., Xiao X.Q., Ng A.K., Chen P.M., Chung W., Lee N.T., Carlier P.R., Pang Y., and Han H.Y. Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor. Neurosci. Lett. 288 (2000) 95-98
21. Xiao X.Q., Lee N.T., Carlier P.R., Pang Y., and Han Y.F. Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine. Neurosci. Lett. 290 (2000) 197-200
22. Yao H., Takasawa R., Fukuda K., Shiokawa D., Sadanaga-Akiyoshi F., Ibayashi S., Tanuma S., and Uchimura H. DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats. Brain Res. Mol. Brain. Res. 91 (2001) 112-118
23. Youdim M.B., and Buccafusco J.J. Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders. Trends. Pharmacol. Sci. 26 (2005) 27-35
24. Zhang H.Y. One-compound-multiple-targets strategy to combat Alzheimer's disease. FEBS Lett. 579 (2005) 5260-5264
25. Zhang Y., Wang L., Li J., and Wang X.L. 2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia. J. Pharmacol. Exp. Ther. 317 (2006) 973-979