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Volumn 86, Issue 11, 2008, Pages 2432-2440

Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats

Author keywords

Acetylcholinesterase inhibitor; Calcium; Huperzine A; Ischemia; Mitochondria

Indexed keywords

CYTOCHROME C OXIDASE; HUPERZINE A; OXOGLUTARATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

EID: 49349110270     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21681     Document Type: Article
Times cited : (30)

References (63)
  • 1
    • 0029097980 scopus 로고
    • Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain
    • Almeida A, Allen KL, Bates TE, Clark JB. 1995. Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. J Neurochem 65:1698-1703.
    • (1995) J Neurochem , vol.65 , pp. 1698-1703
    • Almeida, A.1    Allen, K.L.2    Bates, T.E.3    Clark, J.B.4
  • 2
    • 0034535252 scopus 로고    scopus 로고
    • Quantitative biochemical and ultrastructural comparison of mitochondrial permeability transition in isolated brain and liver mitochondria: Evidence for reduced sensitivity of brain mitochondria
    • Berman SB, Watkins SC, Hastings TG. 2000. Quantitative biochemical and ultrastructural comparison of mitochondrial permeability transition in isolated brain and liver mitochondria: evidence for reduced sensitivity of brain mitochondria. Exp Neurol 164:415-425.
    • (2000) Exp Neurol , vol.164 , pp. 415-425
    • Berman, S.B.1    Watkins, S.C.2    Hastings, T.G.3
  • 4
    • 0037427445 scopus 로고    scopus 로고
    • Mitochondria and ischemic reperfusion damage in the adult and in the developing brain
    • Blomgren K, Zhu C, Hallin U, Hagberg H. 2003. Mitochondria and ischemic reperfusion damage in the adult and in the developing brain. Biochem Biophys Res Commun 304:551-559.
    • (2003) Biochem Biophys Res Commun , vol.304 , pp. 551-559
    • Blomgren, K.1    Zhu, C.2    Hallin, U.3    Hagberg, H.4
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 6
    • 33846237937 scopus 로고    scopus 로고
    • Acute treatment and long-term management of stroke in developing countries
    • Brainin M, Teuschl Y, Kalra L. 2007. Acute treatment and long-term management of stroke in developing countries. Lancet Neurol 6:553-561.
    • (2007) Lancet Neurol , vol.6 , pp. 553-561
    • Brainin, M.1    Teuschl, Y.2    Kalra, L.3
  • 7
    • 0141815741 scopus 로고    scopus 로고
    • Production of reactive oxygen species by mitochondria: Central role of complex III
    • Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ. 2003. Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem 278:36027-36031.
    • (2003) J Biol Chem , vol.278 , pp. 36027-36031
    • Chen, Q.1    Vazquez, E.J.2    Moghaddas, S.3    Hoppel, C.L.4    Lesnefsky, E.J.5
  • 8
    • 0344392793 scopus 로고    scopus 로고
    • Reduction of mitochondrial electron transport complex activity is restricted to the ischemic focus after transient focal cerebral ischemia in rats: A histochemical volumetric analysis
    • Christensen T, Diemer NH. 2003. Reduction of mitochondrial electron transport complex activity is restricted to the ischemic focus after transient focal cerebral ischemia in rats: a histochemical volumetric analysis. Neurochem Res 28:1805-1812.
    • (2003) Neurochem Res , vol.28 , pp. 1805-1812
    • Christensen, T.1    Diemer, N.H.2
  • 9
    • 19444383084 scopus 로고    scopus 로고
    • Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35
    • Clementi ME, Marini S, Coletta M, Orsini F, Giardina B, Misiti F. 2005. Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: role of the redox state of methionine-35. FEBS Lett 579:2913-2918.
    • (2005) FEBS Lett , vol.579 , pp. 2913-2918
    • Clementi, M.E.1    Marini, S.2    Coletta, M.3    Orsini, F.4    Giardina, B.5    Misiti, F.6
  • 10
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA. 1999. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391-397.
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 11
    • 0023696871 scopus 로고
    • Effect of a deficiency of thiamine on brain pyruvate dehydrogenase: Enzyme assay by three different methods
    • Elnageh KM, Gaitonde MK. 1988. Effect of a deficiency of thiamine on brain pyruvate dehydrogenase: enzyme assay by three different methods. J Neurochem 51:1482-1489.
    • (1988) J Neurochem , vol.51 , pp. 1482-1489
    • Elnageh, K.M.1    Gaitonde, M.K.2
  • 12
    • 0027484368 scopus 로고
    • Assay conditions for the mitochondrial NADH:coenzyme Q oxidoreductase
    • Estornell E, Fato R, Pallotti F, Lenaz G. 1993. Assay conditions for the mitochondrial NADH:coenzyme Q oxidoreductase. FEBS Lett 332: 127-131.
    • (1993) FEBS Lett , vol.332 , pp. 127-131
    • Estornell, E.1    Fato, R.2    Pallotti, F.3    Lenaz, G.4
  • 13
    • 0033510014 scopus 로고    scopus 로고
    • Mitochondria in neurodegeneration: Acute ischermia and chronic neurodegenerative diseases
    • Fiskum G, Murphy AN, Beal MF. 1999. Mitochondria in neurodegeneration: acute ischermia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab 19:351-369.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 351-369
    • Fiskum, G.1    Murphy, A.N.2    Beal, M.F.3
  • 14
    • 0037073535 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress after global brain ischemia in rats
    • Friberg H, Wieloch T, Castilho RF. 2002. Mitochondrial oxidative stress after global brain ischemia in rats. Neurosci Lett 334:111-114.
    • (2002) Neurosci Lett , vol.334 , pp. 111-114
    • Friberg, H.1    Wieloch, T.2    Castilho, R.F.3
  • 15
    • 18044372996 scopus 로고    scopus 로고
    • Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats
    • Fujiki M, Kobayashi H, Uchida S, Inoue R, Ishii K. 2005. Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats. Brain Res 1043:236-241.
    • (2005) Brain Res , vol.1043 , pp. 236-241
    • Fujiki, M.1    Kobayashi, H.2    Uchida, S.3    Inoue, R.4    Ishii, K.5
  • 16
    • 0037664459 scopus 로고    scopus 로고
    • Reactive oxygen species induce swelling and cytochrome c release but not transmembrane depolarization in isolated rat brain mitochondria
    • Galindo MF, Jordan J, Gonzalez-Garcia C, Cena V. 2003. Reactive oxygen species induce swelling and cytochrome c release but not transmembrane depolarization in isolated rat brain mitochondria. Br J Pharmacol 139:797-804.
    • (2003) Br J Pharmacol , vol.139 , pp. 797-804
    • Galindo, M.F.1    Jordan, J.2    Gonzalez-Garcia, C.3    Cena, V.4
  • 17
    • 33645855623 scopus 로고    scopus 로고
    • Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism
    • Gao X, Tang XC. 2006. Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism. J Neurosci Res 83:1048-1057.
    • (2006) J Neurosci Res , vol.83 , pp. 1048-1057
    • Gao, X.1    Tang, X.C.2
  • 18
    • 77957014831 scopus 로고
    • Preparations of succinate-cytochrome c reductase and the cytochromeb-c1 particle, and reconstitution of succinate-cytochrome c reductase
    • King TE. 1967, Preparations of succinate-cytochrome c reductase and the cytochromeb-c1 particle, and reconstitution of succinate-cytochrome c reductase. Methods Enzymol 10:216-225.
    • (1967) Methods Enzymol , vol.10 , pp. 216-225
    • King, T.E.1
  • 19
    • 0031953601 scopus 로고    scopus 로고
    • Calcium in ischemic cell death
    • Kristian T, Siesjo BK. 1998. Calcium in ischemic cell death. Stroke 29: 705-718.
    • (1998) Stroke , vol.29 , pp. 705-718
    • Kristian, T.1    Siesjo, B.K.2
  • 20
    • 0030130569 scopus 로고    scopus 로고
    • Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat
    • Kuroda S, Katsura K, Hillered L, Bates TE, BK S. 1996a. Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiol Dis 3:149-157.
    • (1996) Neurobiol Dis , vol.3 , pp. 149-157
    • Kuroda, S.1    Katsura, K.2    Hillered, L.3    Bates, T.E.4    BK, S.5
  • 21
    • 0029872044 scopus 로고    scopus 로고
    • Secondary bioenergetic failure after transient focal ischaemia is due to mitochondrial injury
    • Kuroda S, Katsura KI, Tsuchidate R, Siesjö BK. 1996b. Secondary bioenergetic failure after transient focal ischaemia is due to mitochondrial injury. Acta Physiol Scand 156:149-150.
    • (1996) Acta Physiol Scand , vol.156 , pp. 149-150
    • Kuroda, S.1    Katsura, K.I.2    Tsuchidate, R.3    Siesjö, B.K.4
  • 23
    • 0018338308 scopus 로고
    • Preparation of synaptic and nonsynaptic mitochondria from mammalian brain
    • Lai JC, Clark JB. 1979. Preparation of synaptic and nonsynaptic mitochondria from mammalian brain. Methods Enzymol 55:51-60.
    • (1979) Methods Enzymol , vol.55 , pp. 51-60
    • Lai, J.C.1    Clark, J.B.2
  • 24
    • 0022972426 scopus 로고
    • Brain alpha-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution, and effects of inhibitors
    • Lai JC, Cooper AJ. 1986. Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors. J Neurochem 47:1376-1386.
    • (1986) J Neurochem , vol.47 , pp. 1376-1386
    • Lai, J.C.1    Cooper, A.J.2
  • 25
    • 0033600277 scopus 로고    scopus 로고
    • The changing landscape of ischaemic brain injury mechanisms
    • Lee JM, Zipfel GJ, Choi DW. 1999. The changing landscape of ischaemic brain injury mechanisms. Nature 399(Suppl):A7-14.
    • (1999) Nature , vol.399 , Issue.SUPPL.
    • Lee, J.M.1    Zipfel, G.J.2    Choi, D.W.3
  • 26
    • 0033830318 scopus 로고    scopus 로고
    • Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia
    • Li PA, Kristian T, He QP, Siesjo BK. 2000. Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia. Exp Neurol 165:153-163.
    • (2000) Exp Neurol , vol.165 , pp. 153-163
    • Li, P.A.1    Kristian, T.2    He, Q.P.3    Siesjo, B.K.4
  • 27
    • 34547136698 scopus 로고    scopus 로고
    • Galantamine postischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils
    • Lorrio S, Sobrado M, Arias E, Roda JM, Garcia AG, Lopez MG. 2007. Galantamine postischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils. J Pharmacol Exp Ther 322:591-599.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 591-599
    • Lorrio, S.1    Sobrado, M.2    Arias, E.3    Roda, J.M.4    Garcia, A.G.5    Lopez, M.G.6
  • 29
    • 0033495895 scopus 로고    scopus 로고
    • Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion
    • Matsumoto S, Friberg H, Ferrand-Drake M, Wieloch T. 1999. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 19:736-741.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 736-741
    • Matsumoto, S.1    Friberg, H.2    Ferrand-Drake, M.3    Wieloch, T.4
  • 30
    • 0031938318 scopus 로고    scopus 로고
    • Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils
    • Nanri M, Yamamoto J, Miyake H, Watanabe H. 1998. Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils. Jpn J Pharmacol 76:23-29.
    • (1998) Jpn J Pharmacol , vol.76 , pp. 23-29
    • Nanri, M.1    Yamamoto, J.2    Miyake, H.3    Watanabe, H.4
  • 32
  • 33
    • 0024207765 scopus 로고
    • Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion
    • Obrenovitch TP, Garofalo O, Harris RJ, Bordi L, Ono M, Momma F, Bachelard HS, Symon L. 1988. Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion. J Cereb Blood Flow Metab 8:866-874.
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 866-874
    • Obrenovitch, T.P.1    Garofalo, O.2    Harris, R.J.3    Bordi, L.4    Ono, M.5    Momma, F.6    Bachelard, H.S.7    Symon, L.8
  • 34
    • 0035227198 scopus 로고    scopus 로고
    • Isolation and subfractionation of mitochondria from animal cells and tissue culture lines
    • Pallotti F, Lenaz G. 2001. Isolation and subfractionation of mitochondria from animal cells and tissue culture lines. Methods Cell Biol 65:1-35.
    • (2001) Methods Cell Biol , vol.65 , pp. 1-35
    • Pallotti, F.1    Lenaz, G.2
  • 35
    • 0033984710 scopus 로고    scopus 로고
    • The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles
    • Paradies G, Petrosillo G, Pistolese M, Ruggiero FM. 2000. The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles. FEBS Lett 466:323-326.
    • (2000) FEBS Lett , vol.466 , pp. 323-326
    • Paradies, G.1    Petrosillo, G.2    Pistolese, M.3    Ruggiero, F.M.4
  • 36
    • 0142178155 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway: A missing link in neuroimmunomodulation
    • Pavlov VA, Wang H, Czura CJ, Friedman SG, Tracey KJ. 2003. The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol Med 9:125-134.
    • (2003) Mol Med , vol.9 , pp. 125-134
    • Pavlov, V.A.1    Wang, H.2    Czura, C.J.3    Friedman, S.G.4    Tracey, K.J.5
  • 37
    • 0031665617 scopus 로고    scopus 로고
    • A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: Evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-Doppler flowmetry
    • Schmid-Elsaesser R, Zausinger S, Hungerhuber E, Baethmann A, Reulen HJ. 1998. A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-Doppler flowmetry. Stroke 29:2162-2170.
    • (1998) Stroke , vol.29 , pp. 2162-2170
    • Schmid-Elsaesser, R.1    Zausinger, S.2    Hungerhuber, E.3    Baethmann, A.4    Reulen, H.J.5
  • 38
    • 0029897272 scopus 로고    scopus 로고
    • Cholinergic control of cerebral blood flow in stroke, trauma and aging
    • Scremin OU, Jenden DJ. 1996. Cholinergic control of cerebral blood flow in stroke, trauma and aging. Life Sci 58:2011-2018.
    • (1996) Life Sci , vol.58 , pp. 2011-2018
    • Scremin, O.U.1    Jenden, D.J.2
  • 39
    • 0030861927 scopus 로고    scopus 로고
    • Cholinergic modulation of cerebral cortical blood flow changes induced by trauma
    • Scremin OU, Li MG, Jenden DJ. 1997. Cholinergic modulation of cerebral cortical blood flow changes induced by trauma. J Neurotrauma 14:573-586.
    • (1997) J Neurotrauma , vol.14 , pp. 573-586
    • Scremin, O.U.1    Li, M.G.2    Jenden, D.J.3
  • 41
    • 0025471534 scopus 로고
    • Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation
    • Sims NR. 1990. Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation. J Neurochem 55:698-707.
    • (1990) J Neurochem , vol.55 , pp. 698-707
    • Sims, N.R.1
  • 42
    • 0036175596 scopus 로고    scopus 로고
    • Mitochondrial contributions to tissue damage in stroke
    • Sims NR, Anderson MF. 2002. Mitochondrial contributions to tissue damage in stroke. Neurochem Int 40:511-526.
    • (2002) Neurochem Int , vol.40 , pp. 511-526
    • Sims, N.R.1    Anderson, M.F.2
  • 43
    • 0032189043 scopus 로고    scopus 로고
    • The antioxidant defences of brain mitochondria during short-term forebrain ischemia and recirculation in the rat
    • Sims NR, Williams VK, Zaidan E, Powell JA. 1998. The antioxidant defences of brain mitochondria during short-term forebrain ischemia and recirculation in the rat. Brain Res Mol Brain Res 60:141-149.
    • (1998) Brain Res Mol Brain Res , vol.60 , pp. 141-149
    • Sims, N.R.1    Williams, V.K.2    Zaidan, E.3    Powell, J.A.4
  • 45
    • 0029053984 scopus 로고
    • Post-ischemic administration of the acetylcholinesterase inhibitor ENA-713 prevents delayed neuronal death in the gerbil hippocampus
    • Tanaka K, Mizukawa K, Ogawa N, Mori A. 1995. Post-ischemic administration of the acetylcholinesterase inhibitor ENA-713 prevents delayed neuronal death in the gerbil hippocampus. Neurochem Res 20:663-667.
    • (1995) Neurochem Res , vol.20 , pp. 663-667
    • Tanaka, K.1    Mizukawa, K.2    Ogawa, N.3    Mori, A.4
  • 46
    • 0029964226 scopus 로고    scopus 로고
    • Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines
    • Trounce IA, Kim YL, Jun AS, Wallace DC. 1996. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines. Methods Enzymol 264:484-509.
    • (1996) Methods Enzymol , vol.264 , pp. 484-509
    • Trounce, I.A.1    Kim, Y.L.2    Jun, A.S.3    Wallace, D.C.4
  • 47
    • 0030893633 scopus 로고    scopus 로고
    • Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate
    • Ved HS, Koenig ML, Dave JR, Doctor BP. 1997. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Nemoreport 8:963-968.
    • (1997) Nemoreport , vol.8 , pp. 963-968
    • Ved, H.S.1    Koenig, M.L.2    Dave, J.R.3    Doctor, B.P.4
  • 49
    • 0003093544 scopus 로고    scopus 로고
    • Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
    • Wang LM, Han YF, Tang XC. 2000. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur J Pharmacol 398:65-72.
    • (2000) Eur J Pharmacol , vol.398 , pp. 65-72
    • Wang, L.M.1    Han, Y.F.2    Tang, X.C.3
  • 50
    • 0037072513 scopus 로고    scopus 로고
    • Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia
    • Wang LS, Zhou J, Shao XM, Tang XC. 2002. Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res 949:162-170.
    • (2002) Brain Res , vol.949 , pp. 162-170
    • Wang, L.S.1    Zhou, J.2    Shao, X.M.3    Tang, X.C.4
  • 51
    • 20944446415 scopus 로고    scopus 로고
    • Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease
    • Wang R, Tang XC. 2005. Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease. Neurosignals 14:71-82.
    • (2005) Neurosignals , vol.14 , pp. 71-82
    • Wang, R.1    Tang, X.C.2
  • 52
    • 33846849308 scopus 로고    scopus 로고
    • Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury
    • Wang ZF, Tang XC. 2007. Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury. FEBS Lett 581:596-602.
    • (2007) FEBS Lett , vol.581 , pp. 596-602
    • Wang, Z.F.1    Tang, X.C.2
  • 53
    • 33744517635 scopus 로고    scopus 로고
    • Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
    • Wang ZF, Tang LL, Yan H, Wang YJ, Tang XC. 2006. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice. Pharmacol Biochem Behav 83:603-611.
    • (2006) Pharmacol Biochem Behav , vol.83 , pp. 603-611
    • Wang, Z.F.1    Tang, L.L.2    Yan, H.3    Wang, Y.J.4    Tang, X.C.5
  • 54
    • 2042432480 scopus 로고
    • Cytochrome, oxidase from beef heart mitochondria
    • Wharton DC, Tzagoloff A. 1967. Cytochrome, oxidase from beef heart mitochondria. Methods Enzymol 10:245-250.
    • (1967) Methods Enzymol , vol.10 , pp. 245-250
    • Wharton, D.C.1    Tzagoloff, A.2
  • 55
    • 0034625561 scopus 로고    scopus 로고
    • Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells
    • Xiao XQ, Wang R, Han YF, Tang XC. 2000a. Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells. Neurosci Lett 286:155-158.
    • (2000) Neurosci Lett , vol.286 , pp. 155-158
    • Xiao, X.Q.1    Wang, R.2    Han, Y.F.3    Tang, X.C.4
  • 56
    • 0034284410 scopus 로고    scopus 로고
    • Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury
    • Xiao XQ, Wang R, Tang XC. 2000b. Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury. J Neurosci Res 61:564-569.
    • (2000) J Neurosci Res , vol.61 , pp. 564-569
    • Xiao, X.Q.1    Wang, R.2    Tang, X.C.3
  • 57
    • 49349095868 scopus 로고    scopus 로고
    • Analyze of intervention effect of huperzine A on vascular dementia
    • Yin FM, Du YY, Wang LE. 2001. Analyze of intervention effect of huperzine A on vascular dementia. Mod Rehabil 5:75-75.
    • (2001) Mod Rehabil , vol.5 , pp. 75-75
    • Yin1    FM, D.Y.2    Wang, L.E.3
  • 58
    • 0033612939 scopus 로고    scopus 로고
    • Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia
    • Yoshimoto T, Siesjo BK. 1999. Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia. Brain Res 839:283-291.
    • (1999) Brain Res , vol.839 , pp. 283-291
    • Yoshimoto, T.1    Siesjo, B.K.2
  • 59
    • 39149123780 scopus 로고    scopus 로고
    • Non-cholinergic effects of huperzine A: Beyond inhibition of acetylcholinesterase
    • Zhang HY, Yan H, Tang XC. 2008. Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. Cell Mol Neurobiol 28:173-183.
    • (2008) Cell Mol Neurobiol , vol.28 , pp. 173-183
    • Zhang, H.Y.1    Yan, H.2    Tang, X.C.3
  • 60
    • 0242489050 scopus 로고    scopus 로고
    • In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain
    • Zhang S, Fu J, Zhou Z. 2004. In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain. Toxicol In Vitro 18:71-77.
    • (2004) Toxicol In Vitro , vol.18 , pp. 71-77
    • Zhang, S.1    Fu, J.2    Zhou, Z.3
  • 61
    • 49349104734 scopus 로고    scopus 로고
    • Clinical observation of effect of huperzine A on 29 vascular dementia patients
    • Zhong ZG, Liang KZ. 2004. Clinical observation of effect of huperzine A on 29 vascular dementia patients. J Hainan Med Coll 10:251-252.
    • (2004) J Hainan Med Coll , vol.10 , pp. 251-252
    • Zhong, Z.G.1    Liang, K.Z.2
  • 62
    • 0035919804 scopus 로고    scopus 로고
    • Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation
    • Zhou J, Fu Y, Tang XC. 2001a. Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation. Neuroreport 12:2073-2077.
    • (2001) Neuroreport , vol.12 , pp. 2073-2077
    • Zhou, J.1    Fu, Y.2    Tang, X.C.3
  • 63
    • 0035834265 scopus 로고    scopus 로고
    • Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils
    • Zhou J, Zhang HY, Tang XC. 2001b. Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett 313:137-140.
    • (2001) Neurosci Lett , vol.313 , pp. 137-140
    • Zhou, J.1    Zhang, H.Y.2    Tang, X.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.