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Volumn 239, Issue 1-2, 2011, Pages 61-67

The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis

Author keywords

Blood brain barrier; Blood spinal cord barrier; Experimental autoimmune encephalomyelitis; Fasudil; Multiple sclerosis

Indexed keywords

EVANS BLUE; FASUDIL; MESSENGER RNA; MYELIN; MYOSIN LIGHT CHAIN; OCCLUDIN; PROTEIN ROCK2; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

EID: 80054953599     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.08.015     Document Type: Article
Times cited : (28)

References (55)
  • 1
    • 34248643192 scopus 로고    scopus 로고
    • Immunopathogenesis of multiple sclerosis
    • Agrawal S.M., Yong V.W. Immunopathogenesis of multiple sclerosis. Int. Rev. Neurobiol. 2007, 79:99-126.
    • (2007) Int. Rev. Neurobiol. , vol.79 , pp. 99-126
    • Agrawal, S.M.1    Yong, V.W.2
  • 2
    • 68049132843 scopus 로고    scopus 로고
    • Ninjurin1 is expressed in myeloid cells and mediates endothelium adhesion in the brains of EAE rats
    • 18
    • Ahn B.J., Lee H.J., Shin M.W., Choi J.H., Jeong J.W., Kim K.W. Ninjurin1 is expressed in myeloid cells and mediates endothelium adhesion in the brains of EAE rats. Biochem. Biophys. Res. Commun. 2009, 387(2):321-325. 18.
    • (2009) Biochem. Biophys. Res. Commun. , vol.387 , Issue.2 , pp. 321-325
    • Ahn, B.J.1    Lee, H.J.2    Shin, M.W.3    Choi, J.H.4    Jeong, J.W.5    Kim, K.W.6
  • 3
    • 78650173611 scopus 로고    scopus 로고
    • Disruption of central nervous system barriers in multiple sclerosis
    • Alvarez J.I., Cayrol R., Prat A. Disruption of central nervous system barriers in multiple sclerosis. Biochim. Biophys. Acta 2010, 10.1016/j.bbadis.2010.06.017.
    • (2010) Biochim. Biophys. Acta
    • Alvarez, J.I.1    Cayrol, R.2    Prat, A.3
  • 5
    • 0029799520 scopus 로고    scopus 로고
    • Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein
    • Balda M.S., Whitney J.A., Flores C., Gonzalez S., Cereijido M., Matter K. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J. Cell Biol. 1996, 134:1031-1049.
    • (1996) J. Cell Biol. , vol.134 , pp. 1031-1049
    • Balda, M.S.1    Whitney, J.A.2    Flores, C.3    Gonzalez, S.4    Cereijido, M.5    Matter, K.6
  • 6
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: an overview: structure, regulation, and clinical implications
    • Ballabh P., Braun A., Nedergaard M. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol. Dis. 2004, 16:1-13.
    • (2004) Neurobiol. Dis. , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 7
    • 77950516409 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement
    • Bauer A.T., Burgers H.F., Rabie T., Marti H.H. Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement. J. Cereb. Blood Flow Metab. 2009, 30:837-848.
    • (2009) J. Cereb. Blood Flow Metab. , vol.30 , pp. 837-848
    • Bauer, A.T.1    Burgers, H.F.2    Rabie, T.3    Marti, H.H.4
  • 8
    • 78650185098 scopus 로고    scopus 로고
    • Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE
    • Bennett J., Kollar A., Biron K.E., Reickmann P., Jefferies W.A., McQuaid S. Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE. J. Neuroimmunol. 2010, 10.1016/j.jneuroim.2010.08.011.
    • (2010) J. Neuroimmunol.
    • Bennett, J.1    Kollar, A.2    Biron, K.E.3    Reickmann, P.4    Jefferies, W.A.5    McQuaid, S.6
  • 10
    • 3242705077 scopus 로고    scopus 로고
    • RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin
    • Bruewer M., Hopkins A.M., Hobert M.E., Nusrat A., Madara J.L. RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am. J. Physiol. Cell Physiol. 2004, 287:C327-C335.
    • (2004) Am. J. Physiol. Cell Physiol. , vol.287
    • Bruewer, M.1    Hopkins, A.M.2    Hobert, M.E.3    Nusrat, A.4    Madara, J.L.5
  • 11
    • 0030748172 scopus 로고    scopus 로고
    • COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos
    • Chen Y., Merzdorf C., Paul D.L., Goodenough D.A. COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J. Cell Biol. 1997, 138:891-899.
    • (1997) J. Cell Biol. , vol.138 , pp. 891-899
    • Chen, Y.1    Merzdorf, C.2    Paul, D.L.3    Goodenough, D.A.4
  • 12
    • 77954412580 scopus 로고    scopus 로고
    • Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo
    • Deng L., Li G., Li R., Liu Q., He Q., Zhang J. Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo. Cancer Biol. Ther. 2010, 9:875-884.
    • (2010) Cancer Biol. Ther. , vol.9 , pp. 875-884
    • Deng, L.1    Li, G.2    Li, R.3    Liu, Q.4    He, Q.5    Zhang, J.6
  • 13
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
    • Engelhardt B., Ransohoff R.M. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol. 2005, 26:485-495.
    • (2005) Trends Immunol. , vol.26 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 14
    • 34248355132 scopus 로고    scopus 로고
    • Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models
    • Fabis M.J., Scott G.S., Kean R.B., Koprowski H., Hooper D.C. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:5656-5661.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 5656-5661
    • Fabis, M.J.1    Scott, G.S.2    Kean, R.B.3    Koprowski, H.4    Hooper, D.C.5
  • 16
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins B.T., Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 2005, 57:173-185.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 17
    • 0032514134 scopus 로고    scopus 로고
    • Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases
    • Jou T.S., Schneeberger E.E., Nelson W.J. Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 1998, 142:101-115.
    • (1998) J. Cell Biol. , vol.142 , pp. 101-115
    • Jou, T.S.1    Schneeberger, E.E.2    Nelson, W.J.3
  • 18
    • 0141926694 scopus 로고    scopus 로고
    • Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination
    • Kirk J., Plumb J., Mirakhur M., McQuaid S. Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination. J. Pathol. 2003, 201:319-327.
    • (2003) J. Pathol. , vol.201 , pp. 319-327
    • Kirk, J.1    Plumb, J.2    Mirakhur, M.3    McQuaid, S.4
  • 19
    • 33846134731 scopus 로고    scopus 로고
    • Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis
    • Leech S., Kirk J., Plumb J., McQuaid S. Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis. Neuropathol. Appl. Neurobiol. 2007, 33:86-98.
    • (2007) Neuropathol. Appl. Neurobiol. , vol.33 , pp. 86-98
    • Leech, S.1    Kirk, J.2    Plumb, J.3    McQuaid, S.4
  • 20
    • 33746313958 scopus 로고    scopus 로고
    • T-cell trafficking competence is required for CNS invasion
    • Lees J.R., Archambault A.S., Russell J.H. T-cell trafficking competence is required for CNS invasion. J. Neuroimmunol. 2006, 177(1-2):1-10.
    • (2006) J. Neuroimmunol. , vol.177 , Issue.1-2 , pp. 1-10
    • Lees, J.R.1    Archambault, A.S.2    Russell, J.H.3
  • 21
    • 0029789678 scopus 로고    scopus 로고
    • The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
    • Leung T., Chen X.Q., Manser E., Lim L. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 1996, 16:5313-5327.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5313-5327
    • Leung, T.1    Chen, X.Q.2    Manser, E.3    Lim, L.4
  • 23
    • 33947543465 scopus 로고    scopus 로고
    • Inflammatory cell migration into the central nervous system: a few new twists on an old tale
    • Man S., Ubogu E.E., Ransohoff R.M. Inflammatory cell migration into the central nervous system: a few new twists on an old tale. Brain Pathol. 2007, 17:243-250.
    • (2007) Brain Pathol. , vol.17 , pp. 243-250
    • Man, S.1    Ubogu, E.E.2    Ransohoff, R.M.3
  • 24
    • 0038273906 scopus 로고    scopus 로고
    • Holey barrier: claudins and the regulation of brain endothelial permeability
    • Matter K., Balda M.S. Holey barrier: claudins and the regulation of brain endothelial permeability. J. Cell Biol. 2003, 161:459-460.
    • (2003) J. Cell Biol. , vol.161 , pp. 459-460
    • Matter, K.1    Balda, M.S.2
  • 25
    • 58149153012 scopus 로고    scopus 로고
    • Upregulation of water channel aquaporin-4 in experimental autoimmune encephalomyelitis
    • Miyamoto K., Nagaosa N., Motoyama M., Kataoka K., Kusunoki S. Upregulation of water channel aquaporin-4 in experimental autoimmune encephalomyelitis. J. Neurol. Sci. 2009, 276:103-107.
    • (2009) J. Neurol. Sci. , vol.276 , pp. 103-107
    • Miyamoto, K.1    Nagaosa, N.2    Motoyama, M.3    Kataoka, K.4    Kusunoki, S.5
  • 27
    • 18944372230 scopus 로고    scopus 로고
    • Rho kinase, a promising drug target for neurological disorders
    • Mueller B.K., Mack H., Teusch N. Rho kinase, a promising drug target for neurological disorders. Nat. Rev. Drug Discov. 2005, 4:387-398.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 387-398
    • Mueller, B.K.1    Mack, H.2    Teusch, N.3
  • 29
    • 33846515216 scopus 로고    scopus 로고
    • Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology
    • Padden M., Leech S., Craig B., Kirk J., Brankin B., McQuaid S. Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology. Acta Neuropathol. 2007, 113:177-186.
    • (2007) Acta Neuropathol. , vol.113 , pp. 177-186
    • Padden, M.1    Leech, S.2    Craig, B.3    Kirk, J.4    Brankin, B.5    McQuaid, S.6
  • 30
    • 42449112111 scopus 로고    scopus 로고
    • Inhibition of Rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis
    • Paintlia A.S., Paintlia M.K., Singh A.K., Singh I. Inhibition of Rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol. Pharmacol. 2008, 73:1381-1393.
    • (2008) Mol. Pharmacol. , vol.73 , pp. 1381-1393
    • Paintlia, A.S.1    Paintlia, M.K.2    Singh, A.K.3    Singh, I.4
  • 32
    • 33747368249 scopus 로고    scopus 로고
    • Blood-brain barrier: structural components and function under physiologic and pathologic conditions
    • Persidsky Y., Ramirez S.H., Haorah J., Kanmogne G.D. Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J. Neuroimmune Pharmacol. 2006, 1:223-236.
    • (2006) J. Neuroimmune Pharmacol. , vol.1 , pp. 223-236
    • Persidsky, Y.1    Ramirez, S.H.2    Haorah, J.3    Kanmogne, G.D.4
  • 34
    • 0036211141 scopus 로고    scopus 로고
    • Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis
    • Plumb J., McQuaid S., Mirakhur M., Kirk J. Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol. 2002, 12:154-169.
    • (2002) Brain Pathol. , vol.12 , pp. 154-169
    • Plumb, J.1    McQuaid, S.2    Mirakhur, M.3    Kirk, J.4
  • 35
    • 0033977406 scopus 로고    scopus 로고
    • Further evidence for a role of nitric oxide in experimental allergic encephalomyelitis: aminoguanidine treatment modifies its clinical evolution
    • Pozza M., Bettelli C., Aloe L., Giardino L., Calza L. Further evidence for a role of nitric oxide in experimental allergic encephalomyelitis: aminoguanidine treatment modifies its clinical evolution. Brain Res. 2000, 855:39-46.
    • (2000) Brain Res. , vol.855 , pp. 39-46
    • Pozza, M.1    Bettelli, C.2    Aloe, L.3    Giardino, L.4    Calza, L.5
  • 36
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff R.M., Kivisakk P., Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 2003, 3:569-581.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 39
    • 0035796895 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis
    • Scott G.S., Hake P., Kean R.B., Virag L., Szabo C., Hooper D.C. Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. J. Neuroimmunol. 2001, 117:78-86.
    • (2001) J. Neuroimmunol. , vol.117 , pp. 78-86
    • Scott, G.S.1    Hake, P.2    Kean, R.B.3    Virag, L.4    Szabo, C.5    Hooper, D.C.6
  • 40
    • 42249101897 scopus 로고    scopus 로고
    • The Peyer's patch is a critical immunoregulatory site formucosal tolerance in experimental autoimmune encephalomyelitis (EAE)
    • Song F., Wardrop R.M., Gienapp I.E., Stuckman S.S., Meyer A.L., Shawler T., Whitacre C.C. The Peyer's patch is a critical immunoregulatory site formucosal tolerance in experimental autoimmune encephalomyelitis (EAE). Autoimmun. 2008 Jun, 30(4):230-237.
    • (2008) Autoimmun. , vol.30 , Issue.4 , pp. 230-237
    • Song, F.1    Wardrop, R.M.2    Gienapp, I.E.3    Stuckman, S.S.4    Meyer, A.L.5    Shawler, T.6    Whitacre, C.C.7
  • 42
    • 34247555353 scopus 로고    scopus 로고
    • Differentiation and function of Th17 T cells
    • Stockinger B., Veldhoen M. Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 2007, 19:281-286.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 281-286
    • Stockinger, B.1    Veldhoen, M.2
  • 44
    • 0032894607 scopus 로고    scopus 로고
    • Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage
    • Tachibana E., Harada T., Shibuya M., Saito K., Takayasu M., Suzuki Y., Yoshida J. Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage. Acta Neurochir. 1999, 141:13-19.
    • (1999) Acta Neurochir. , vol.141 , pp. 13-19
    • Tachibana, E.1    Harada, T.2    Shibuya, M.3    Saito, K.4    Takayasu, M.5    Suzuki, Y.6    Yoshida, J.7
  • 45
    • 4143102440 scopus 로고    scopus 로고
    • The role of claudins in determining paracellular charge selectivity
    • Van Itallie C.M., Anderson J.M. The role of claudins in determining paracellular charge selectivity. Proc. Am. Thorac. Soc. 2004, 1:38-41.
    • (2004) Proc. Am. Thorac. Soc. , vol.1 , pp. 38-41
    • Van Itallie, C.M.1    Anderson, J.M.2
  • 46
    • 0038730794 scopus 로고    scopus 로고
    • Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view
    • Vorbrodt A.W., Dobrogowska D.H. Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view. Brain Res. Brain Res. Rev. 2003, 42:221-242.
    • (2003) Brain Res. Brain Res. Rev. , vol.42 , pp. 221-242
    • Vorbrodt, A.W.1    Dobrogowska, D.H.2
  • 47
    • 0034823910 scopus 로고    scopus 로고
    • Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia
    • Walsh S.V., Hopkins A.M., Chen J., Narumiya S., Parkos C.A., Nusrat A. Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Gastroenterology 2001, 121:566-579.
    • (2001) Gastroenterology , vol.121 , pp. 566-579
    • Walsh, S.V.1    Hopkins, A.M.2    Chen, J.3    Narumiya, S.4    Parkos, C.A.5    Nusrat, A.6
  • 48
    • 0031047483 scopus 로고    scopus 로고
    • A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier
    • Wong V., Gumbiner B.M. A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J. Cell Biol. 1997, 136:399-409.
    • (1997) J. Cell Biol. , vol.136 , pp. 399-409
    • Wong, V.1    Gumbiner, B.M.2
  • 51
    • 33947493391 scopus 로고    scopus 로고
    • Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    • Yang Y., Estrada E.Y., Thompson J.F., Liu W., Rosenberg G.A. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J. Cereb. Blood Flow Metab. 2007, 27:697-709.
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 697-709
    • Yang, Y.1    Estrada, E.Y.2    Thompson, J.F.3    Liu, W.4    Rosenberg, G.A.5
  • 52
    • 77956337125 scopus 로고    scopus 로고
    • Association between contrast-enhanced MR images and blood-brain barrier disruption following transcranial focused ultrasound
    • Yang F.Y., Horng S.C., Lin Y.S., Kao Y.H. Association between contrast-enhanced MR images and blood-brain barrier disruption following transcranial focused ultrasound. J. Magn. Reson. Imaging 2010, 32:593-599.
    • (2010) J. Magn. Reson. Imaging , vol.32 , pp. 593-599
    • Yang, F.Y.1    Horng, S.C.2    Lin, Y.S.3    Kao, Y.H.4
  • 53
    • 77952357821 scopus 로고    scopus 로고
    • Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor
    • Yu J.Z., Ding J., Ma C.G., Sun C.H., Sun Y.F., Lu C.Z., Xiao B.G. Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor. J. Neurosci. Res. 2010, 88:1664-1672.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 1664-1672
    • Yu, J.Z.1    Ding, J.2    Ma, C.G.3    Sun, C.H.4    Sun, Y.F.5    Lu, C.Z.6    Xiao, B.G.7
  • 54
    • 40149087183 scopus 로고    scopus 로고
    • Lesional accumulation of RhoA(1) cells in brains of experimental autoimmune encephalomyelitis and multiple sclerosis
    • Zhang Z., Schittenhelm J., Meyermann R., Schluesener H.J. Lesional accumulation of RhoA(1) cells in brains of experimental autoimmune encephalomyelitis and multiple sclerosis. Neuropathol. Appl. Neurobiol. 2008, 34:231-240.
    • (2008) Neuropathol. Appl. Neurobiol. , vol.34 , pp. 231-240
    • Zhang, Z.1    Schittenhelm, J.2    Meyermann, R.3    Schluesener, H.J.4
  • 55
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative
    • Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative. Disord. Neuron 2008, 57:178-201.
    • (2008) Disord. Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


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