Basics and dynamics of neonatal and pediatric pharmacology

Handbook of Experimental Pharmacology

Volumn 205, Issue , 2011, Pages 3-49

  Seyberth, Hannsjörg W ^a,b   Kauffman, Ralph E ^c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b University of Missouri at Kansas City ^*  (Germany)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Classification; Developmental changes; Long term safety; Maturation; Neonatal pharmacology; Ontogeny; Pediatric pharmacotherapeutics; Pediatric population; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ANABOLIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CAFFEINE; CHLOROTHIAZIDE; CYCLOSPORIN; DEXAMETHASONE; DOXORUBICIN; ERYTHROMYCIN; FUROSEMIDE; IBUPROFEN; INDOMETACIN; LUNG SURFACTANT; MORPHINE; PENICILLIN G; PHENOBARBITAL; PHENYTOIN; PHOSPHODIESTERASE INHIBITOR; POTASSIUM CHANNEL; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; PSYCHOSTIMULANT AGENT; SULFAFURAZOLE; THEOPHYLLINE; UNINDEXED DRUG; WARFARIN;

ACCIDENT; ACUTE GLOMERULONEPHRITIS; APNEA; ARTICLE; ASTHMA; ATTENTION DEFICIT DISORDER; BILIRUBIN BLOOD LEVEL; BLOOD CLOTTING; BODY COMPOSITION; BREAST FEEDING; BRONCHIOLITIS; CARDIOTOXICITY; CHEMOTHERAPY; CHILD DEVELOPMENT; CHILDHOOD CANCER; CHRONIC LUNG DISEASE; CIGARETTE SMOKING; DEPRESSION; DEVELOPMENTAL STAGE; DIABETES MELLITUS; DISEASE PREDISPOSITION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; DRUG METABOLISM; DRUG OVERDOSE; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG TARGETING; EATING DISORDER; EPILEPSY; EVOLUTIONARY ADAPTATION; GESTATIONAL AGE; GLUCOSE METABOLISM; GROWTH RETARDATION; HEART ARRHYTHMIA; HEART FAILURE; HUMAN; HYPOGLYCEMIA; KERNICTERUS; KIDNEY TUBULE ABSORPTION; LIVER METABOLISM; MALIGNANT NEOPLASTIC DISEASE; MATURATION; NEUROTRANSMISSION; ONTOGENY; PAIN THRESHOLD; PEDIATRIC PHARMACOLOGY; PEDIATRICS; PHARMACEUTICAL CARE; PHYSIOLOGICAL PROCESS; POPULATION DYNAMICS; PREMATURITY; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PUBERTY; RESPIRATION DEPRESSION; RESPIRATORY DISTRESS SYNDROME; RESPIRATORY TRACT INFECTION; RETROLENTAL FIBROPLASIA; RHEUMATIC DISEASE; SEIZURE; SEXUAL BEHAVIOR; SIDE EFFECT; SMOOTH MUSCLE CONTRACTION; SUBSTANCE ABUSE; SUDDEN INFANT DEATH SYNDROME; SUICIDE; TERM BIRTH;

EID: 80054931352     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-20195-0_1     Document Type: Article

References (216)

1. Abraham A, Stafford B (2007) Eating disorders. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
2. Ahlfors CE (2004) Effect of ibuprofen on bilirubin-albumin binding. J Pediatr 144:386-388 (Pubitemid 38333899)
3. Ahmad I, Nemet D, Eliakim A, Koeppel R, Grochow D, Coussens M, Gallitto S, Rich J, Pontello A, Leu SY, Cooper DM, Waffarn F (2010) Body composition and its components in preterm and term newborns: A cross-sectional, multimodal investigation. Am J Hum Biol 22:69-75
4. al-Alaiyan S, al-Rawithi S, Raines D, Yusuf A, Legayada E, Shoukri MM, el-Yazigi A (2001) Caffeine metabolism in premature infants. J Clin Pharmacol 41:620-627 (Pubitemid 32493356)
5. Alcorn J, McNamara PJ (2002) Ontogeny of hepatic and renal systemic clearance pathways in infants: Part II. Clin Pharmacokinet 41:1077-1094 (Pubitemid 35251856)
6. Alemzadeh R, Wyatt DT (2007) Diabets mellitus in children. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
7. Allegaert K, van den Anker JN, Naulaers G, de Hoon J (2007) Determinants of drug metabolism in early neonatal life. Curr Clin Pharmacol 2:23-29 (Pubitemid 46723127)
8. Anderson GD, Lynn AM (2009) Optimizing pediatric dosing: A developmental pharmacologic approach. Pharmacotherapy 29:680-690
9. Asmar BI, Abdel-Haq NM (2005) Macrolides, chloramphenicol, and tetracyclines. In: Yaffe SJ, Aranda JV (eds) Neonatal and pediatric pharmacology - therapeutic principles in practice, 3rd edn. Lippincott Williams & Wilkins, Philadelphia
10. Axelsson I, Jakobsson I, Lindberg T, Polberger S, Benediktsson B, Raiha N (1989) Macromolecular absorption in preterm and term infants. Acta Paediatr Scand 78:532-537 (Pubitemid 19218298)
11. Balazy M, Chemtob S (2008) Trans-arachidonic acids: New mediators of nitro-oxidative stress. Pharmacol Ther 119:275-290
12. Barr FE, Patel NR, Newth CJ (2000) The pharmacologic mechanism by which inhaled epinephrine reduces airway obstruction in respiratory syncytial virus-associated bronchiolitis. J Pediatr 136:699-700 (Pubitemid 30318406)
13. Barrett DA, Rutter N (1994) Transdermal delivery and the premature neonate. Crit Rev Ther Drug Carrier Syst 11:1-30
14. Bartelink IH, Rademaker CM, Schobben AF, van den Anker JN (2006) Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations. Clin Pharmacokinet 45:1077-1097 (Pubitemid 44631388)
15. Battino D, Estienne M, Avanzini G (1995) Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide. Clin Pharmacokinet 29:257-286
16. Beierle I, Meibohm B, Derendorf H (1999) Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther 37:529-547 (Pubitemid 29524971)
17. Ben-Ari Y, Holmes GL (2006) Effects of seizures on developmental processes in the immature brain. Lancet Neurol 5:1055-1063 (Pubitemid 44709981)
18. Ben-Ari Y, Gaiarsa JL, Tyzio R, Khazipov R (2007) GABA: A pioneer transmitter that excites immature neurons and generates primitive oscillations. Physiol Rev 87:1215-1284 (Pubitemid 350041471)
19. Berlin CM Jr (2005) The excretion of drugs and chemicals in human milk. In: Yaffe SJ, Aranda JV (eds) Neonatal and pediatric pharmacology - therapeutic principles in practice, 3rd edn.
20. Lippincott Williams & Wilkins, Philadelpha Berlin CM Jr, Paul IM, Vesell ES (2009) Safety issues of maternal drug therapy during breastfeeding. Clin Pharmacol Ther 85:20-22
21. Bhat AM, Meny RG (1984) Alimentary absorption of gentamicin in preterm infants. Clin Pediatr (Phila) 23:683-685 (Pubitemid 15179781)
22. Bittigau P, Sifringer M, Ikonomidou C (2003) Antiepileptic drugs and apoptosis in the developing brain. Ann NY Acad Sci 993:103-114 (Pubitemid 36808438)
23. Boie Y, Rushmore TH, rmon-Goodwin A, Grygorczyk R, Slipetz DM, Metters KM, Abramovitz M (1994) Cloning and expression of a cDNA for the human prostanoid IP receptor. J Biol Chem 269:12173-12178 (Pubitemid 24196718)
24. Boréus LO (1972) Fetal pharmacology. Raven Press, New York
25. Boris NW, Dalton R (2007) Suicide and attempted suicide. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
26. Bory C, Baltassat P, Porthault M, Bethenod M, Frederich A, Aranda JV (1979) Metabolism of theophylline to caffeine in premature newborn infants. J Pediatr 94:988-993 (Pubitemid 9150255)
27. Bouayad A, Kajino H, Waleh N, Fouron JC, Andelfinger G, Varma DR, Skoll A, Vazquez A, Gobeil F Jr, Clyman RI, Chemtob S (2001) Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus. Am J Physiol Heart Circ Physiol 280:H2342-H2349
28. Bouwmeester NJ, van den Anker JN, Hop WC, Anand KJ, Tibboel D (2003) Age- and therapyrelated effects on morphine requirements and plasma concentrations of morphine and its metabolites in postoperative infants. Br J Anaesth 90:642-652 (Pubitemid 36592339)
29. Brämswig J, Dübbers A (2009) Disorders of pubertal development. Dtsch Arztebl Int 106:295-303
30. Cameron JL (2004) Interrelationships between hormones, behavior, and affect during adolescence: Understanding hormonal, physical, and brain changes occurring in association with pubertal activation of the reproductive axis. Introduction to part III. Ann N Y Acad Sci 1021:110-123 (Pubitemid 38879616)
31. Cary J, Hein K, Dell R (1991) Theophylline disposition in adolescents with asthma. Ther Drug Monit 13:309-313
32. Celsi G, Aperia A (1993) Sodium, chloride, and water. In: Holliday MA, Barratt TM, Evner ED (eds) Pediatric nephrology. Lippincott Williams & Wilkins, Philadelphia
33. Charles BG, Townsend SR, Steer PA, Flenady VJ, Gray PH, Shearman A (2008) Caffeine citrate treatment for extremely premature infants with apnea: Population pharmacokinetics, absolute bioavailability, and implications for therapeutic drug monitoring. Ther Drug Monit 30:709-716
34. Chavasse R, Seddon P, Bara A, McKean M (2002) Short acting beta agonists for recurrent wheeze in children under 2 years of age. Cochrane Database Syst Rev: CD002873
35. Chen N, Aleksa K, Woodland C, Rieder M, Koren G (2006) Ontogeny of drug elimination by the human kidney. Pediatr Nephrol 21:160-168 (Pubitemid 43115865)
36. Chitano P, Wang L, Murphy TM (2005) Mechanisms of airway smooth muscle relaxation during maturation. Can J Physiol Pharmacol 83:833-840 (Pubitemid 43235407)
37. Clapp DW (2006) Developmental regulation of the immune system. Semin Perinatol 30:69-72 (Pubitemid 43767138)
38. Clyman RI, Waleh N, Kajino H, Roman C, Mauray F (2007) Calcium-dependent and calciumsensitizing pathways in the mature and immature ductus arteriosus. Am J Physiol Regul Integr Comp Physiol 293:R1650-R1656 (Pubitemid 47535783)
39. Cnattingius S (2004) The epidemiology of smoking during pregnancy: Smoking prevalence, maternal characteristics, and pregnancy outcomes. Nicotine Tob Res 6(Suppl 2):S125-S140 (Pubitemid 38678838)
40. Coffey B, Shader RI, Greenblatt DJ (1983) Pharmacokinetics of benzodiazepines and psychostimulants in children. J Clin Psychopharmacol 3:217-225 (Pubitemid 13047643)
41. Coffman BL, Rios GR, King CD, Tephly TR (1997) Human UGT2B7 catalyzes morphine glucuronidation. Drug Metab Dispos 25:1-4 (Pubitemid 27045126)
42. Cohen G, Jeffery H, Lagercrantz H, Katz-Salamon M (2010) Long-term reprogramming of cardiovascular function in infants of active smokers. Hypertension 55:722-728
43. Colussi G, Bettinelli A, Tedeschi S, De Ferrari ME, Syren ML, Borsa N, Mattiello C, Casari G, Bianchetti MG (2007) A thiazide test for the diagnosis of renal tubular hypokalemic disorders. Clin J Am Soc Nephrol 2:454-460
44. Commare CE, Tappenden KA (2007) Development of the infant intestine: Implications for nutrition support. Nutr Clin Pract 22:159-173
45. Cox ER, Halloran DR, Homan SM, Welliver S, Mager DE (2008) Trends in the prevalence of chronic medication use in children: 2002-2005. Pediatrics 122:e1053-e1061
46. Dalton R (2007) The development of sexual behavior. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
47. Davis ID, Avner ED (2007) Acute poststreptococcal glomerulonephritis. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
48. de Wildt SN, Kearns GL, Hop WC, Murry DJ, Bdel-Rahman SM, van den Anker JN (2002) Pharmacokinetics and metabolism of oral midazolam in preterm infants. Br J Clin Pharmacol 53:390-392 (Pubitemid 34415590)
49. Donelli MG, Zucchetti M, Robatto A, Perlangeli V, D'Incalci M, Masera G, Rossi MR (1995) Pharmacokinetics of HD-MTX in infants, children, and adolescents with non-B acute lymphoblastic leukemia. Med Pediatr Oncol 24:154-159
50. Doyle LW, Ehrenkranz RA, Halliday HL (2010) Dexamethasone treatment in the first week of life for preventing bronchopulmonary dysplasia in preterm infants: A systematic review. Neonatology 98:217-224
51. Dubois J, Dehaene-Lambertz G, Perrin M, Mangin JF, Cointepas Y, Duchesnay E, Le BD, Hertz- Pannier L (2008) Asynchrony of the early maturation of white matter bundles in healthy infants: quantitative landmarks revealed noninvasively by diffusion tensor imaging. Hum Brain Mapp 29:14-27
52. Ducharme FM, Ni CM, Greenstone I, Lasserson TJ (2010) Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma. Cochrane Database Syst Rev 4: CD005533
53. Dwyer JB, McQuown SC, Leslie FM (2009) The dynamic effects of nicotine on the developing brain. Pharmacol Ther 122:125-139
54. Ellis KJ (2000) Human body composition: In vivo methods. Physiol Rev 80:649-680 (Pubitemid 30164946)
55. Evans N, Moorcraft J (1992) Effect of patency of the ductus arteriosus on blood pressure in very preterm infants. Arch Dis Child 67:1169-1173
56. Fawer CL, Torrado A, Guignard JP (1979) Maturation of renal function in full-term and premature neonates. Helv Paediatr Acta 34:11-21 (Pubitemid 9111122)
57. Fettermann GH, Shuplock NA, Philipp FJ, Gregg HS (1965) The growth and maturation of human glomeruli and proximal convolutions from term to adulthood: Studies by microdissection. Pediatrics 35:601-619
58. Finkelstein JW (1994) The effect of developmental changes in adolescence on drug disposition. J Adolesc Health 15:612-618
59. Fischl R (1902) Ueber Behandlung und Medikation bei Kindern im Allgemeinen. In: Biedert PH (ed) Lehrbuch der Kinderkrankheiten. Verlag von Ferdinand Enke, Stuttgart
60. FitzGerald GA, Patrono C (2001) The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 345:433-442 (Pubitemid 32747607)
61. Fitzgerald M, Walker SM (2009) Infant pain management: A developmental neurobiological approach. Nat Clin Pract Neurol 5:35-50
62. Fleck C, Bräunlich H (1995) Renal handling of drugs and amino acids after impairment of kidney or liver function - influences of maturity and protective treatment. Pharmacol Ther 67:53-77
63. Fomon SJ, Nelson SE (2002) Body composition of the male and female reference infants. Annu Rev Nutr 22:1-17 (Pubitemid 35221451)
64. Food and Drug Administration (2000) International Conference on Harmonisation; guidance on E11 clinical investigation of medicinal products in the pediatric population; availability. Notice. Fed Regist 65:78493-78494
65. Fraser J, Nadeau J, Robertson D, Wood AJ (1981) Regulation of human leukocyte beta receptors by endogenous catecholamines: Relationship of leukocyte beta receptor density to the cardiac sensitivity to isoproterenol. J Clin Invest 67:1777-1784 (Pubitemid 11127571)
66. Freye E (1996) Development of sensory information processing - the ontogenesis of opioid binding sites in nociceptive afferents and their significance in the clinical setting. Acta Anaesthesiol Scand Suppl 109:98-101
67. Frölich JC (1997) A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol Sci 18:30-34 (Pubitemid 27072877)
68. Gadomski AM, Bhasale AL (2006) Bronchodilators for bronchiolitis. Cochrane Database Syst Rev 3: CD001266
69. Gal P, Ransom JL, Davis SA (2006) Possible ibuprofen-induced kernicterus in a near-term infant with moderate hyperbilirubinemia. J Pediatr Pharmacol Ther 11:245-250
70. Glass HC, Wirrell E (2009) Controversies in neonatal seizure management. J Child Neurol 24:591-599
71. Goto S, Seo T, Murata T, Nakada N, Ueda N, Ishitsu T, Nakagawa K (2007) Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. Ther Drug Monit 29:118-121 (Pubitemid 46279885)
72. Green TP, Thompson TR, Johnson DE, Lock JE (1983) Diuresis and pulmonary function in premature infants with respiratory distress syndrome. J Pediatr 103:618-623 (Pubitemid 13011981)
73. Guerrini R (2006) Epilepsy in children. Lancet 367:499-524 (Pubitemid 43208906)
74. Guignard JP (2002) The adverse renal effects of prostaglandin-synthesis inhibitors in the newborn rabbit. Semin Perinatol 26:398-405
75. Hammerman C, Glaser J, Kaplan M, Schimmel MS, Ferber B, Eidelman AI (1998) Indomethacin tocolysis increases postnatal patent ductus arteriosus severity. Pediatrics 102:E56
76. Hammerman C, Shchors I, Jacobson S, Schimmel MS, Bromiker R, Kaplan M, Nir A (2008) Ibuprofen versus continuous indomethacin in premature neonates with patent ductus arteriosus: Is the difference in the mode of administration? Pediatr Res 64:291-297
77. Hartley R, Green M, Quinn MW, Rushforth JA, Levene MI (1994) Development of morphine glucuronidation in premature neonates. Biol Neonate 66:1-9 (Pubitemid 24223906)
78. Hausner E, Fiszman ML, Hanig J, Harlow P, Zornberg G, Sobel S (2008) Long-term consequences of drugs on the paediatric cardiovascular system. Drug Saf 31:1083-1096
79. Hellström A, Ley D, Hansen-Pupp I, Niklasson A, Smith L, Lofqvist C, Hard AL (2009) New insights into the development of retinopathy of prematurity - importance of early weight gain. Acta Paediatr 99:502-508
80. Hendeles L, Weinberger M (1983) Theophylline. A "state of the art" review. Pharmacotherapy 3:2-44
81. Hohmeister J, Kroll A, Wollgarten-Hadamek I, Zohsel K, Demirakca S, Hermann C (2010) Cerebral processing of pain in school-age children with neonatal nociceptive input: An exploratory fMRI study. Pain 150:257-267
82. Holmes GL (2009) The long-term effects of neonatal seizures. Clin Perinatol 36:901-914
83. Holmström G, van Wijngaarden P, Coster DJ, Williams KA (2007) Genetic susceptibility to retinopathy of prematurity: The evidence from clinical and experimental animal studies. Br J Ophthalmol 91:1704-1708 (Pubitemid 350207404)
84. Holopainen IE (2008) Seizures in the developing brain: Cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization. Neurochem Int 52:935-947
85. Holt PG, Upham JW, Sly PD (2005) Contemporaneous maturation of immunologic and respiratory functions during early childhood: Implications for development of asthma prevention strategies. J Allergy Clin Immunol 116:16-24
86. Honda A, Sugimoto Y, Namba T, Watabe A, Irie A, Negishi M, Narumiya S, Ichikawa A (1993) Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype. J Biol Chem 268:7759-7762 (Pubitemid 23120347)
87. Hunt CE (2006) Ontogeny of autonomic regulation in late preterm infants born at 34-37 weeks postmenstrual age. Semin Perinatol 30:73-76 (Pubitemid 43767135)
88. Hunt CE, Hauck FR (2007) Sudden infant death syndrome. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
89. Huss M, Hölling H, Kurth BM, Schlack R (2008) How often are German children and adolescents diagnosed with ADHD? Prevalence based on the judgment of health care professionals: Resultsof the German health and examination survey (KiGGS). Eur Child Adolesc Psychiatry 17(Suppl 1):52-58
90. Hussain T, Greenhalgh K, McLeod KA (2009) Hypoglycaemic syncope in children secondary to beta-blockers. Arch Dis Child 94:968-969
91. Irwin CE Jr (2003) Somatic growth and development during adolescence. In: Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Siegel NJ (eds) Rudolph's pediatrics, 21st edn. McGraw Hill Medical, New York
92. Jain A, Agarwal R, Sankar MJ, Deorari AK, Paul VK (2008a) Hypocalcemia in the newborn. Indian J Pediatr 75:165-169 (Pubitemid 351866434)
93. Jain A, Aggarwal R, Jeevasanker M, Agarwal R, Deorari AK, Paul VK (2008b) Hypoglycemia in the newborn. Indian J Pediatr 75:63-67 (Pubitemid 351723128)
94. Jeck N, Schlingmann KP, Reinalter SC, Komhoff M, Peters M, Waldegger S, Seyberth HW (2005) Salt handling in the distal nephron: Lessons learned from inherited human disorders. Am J Physiol Regul Integr Comp Physiol 288:R782-R795 (Pubitemid 40404149)
95. Johnson TN, Thomson M (2008) Intestinal metabolism and transport of drugs in children: The effects of age and disease. J Pediatr Gastroenterol Nutr 47:3-10
96. Johnson TN, Tanner MS, Taylor CJ, Tucker GT (2001) Enterocytic CYP3A4 in a paediatric population: Developmental changes and the effect of coeliac disease and cystic fibrosis. Br J Clin Pharmacol 51:451-460 (Pubitemid 32852983)
97. Kadan-Lottick NS (2007) Epidemiology of childhood and adolescent cancer. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
98. Kanabar D, Dale S, Rawat M (2007) A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clin Ther 29:2716-2723
99. Kauffman RE (2005) Drug action and therapy in infants and children. In: Yaffe SJ, Aranda JV (eds) Neonatal and pediatric pharmacology - therapeutic principles in practice, 3rd edn. Lippincott Williams & Wilkins, Philadelphia
100. Kauffman RE, Lieh-Lai M(2004) Ibuprofen and increased morbidity in children with asthma: Fact or fiction? Paediatr Drugs 6:267-272 (Pubitemid 39423218)
101. Kauffman RE, Nelson MV (1992) Effect of age on ibuprofen pharmacokinetics and antipyretic response. J Pediatr 121:969-973
102. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE (2003) Developmental pharmacology - drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157-1167 (Pubitemid 37122329)
103. Kennedy M (2008) Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence. Clin Pharmacol Ther 84:662-673
104. Kermorvant-Duchemin E, Sapieha P, Sirinyan M, Beauchamp M, Checchin D, Hardy P, Sennlaub F, Lachapelle P, Chemtob S (2010) Understanding ischemic retinopathies: Emerging concepts from oxygen-induced retinopathy. Doc Ophthalmol 120:51-60
105. Kerschner JE (2007) Otitis media. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
106. Kinney HC (2009) Brainstem mechanisms underlying the sudden infant death syndrome: Evidence from human pathologic studies. Dev Psychobiol 51:223-233
107. Köckerling A, Reinalter SC, Seyberth HW (1996) Impaired response to furosemide in hyperprostaglandin E syndrome: Evidence for a tubular defect in the loop of Henle. J Pediatr 129:519-528 (Pubitemid 27490788)
108. Konduri GG, Kim UO (2009) Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn. Pediatr Clin North Am 56:579-600
109. Koren G, Boucher N (2009) Adverse effects in neonates exposed to SSRIs and SNRI in late gestation - Motherisk update 2008. Can J Clin Pharmacol 16:e66-e67
110. Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, McCarver DG, Hines RN (2004) Developmental expression of human hepatic CYP2C9 and CYP2C19. J Pharmacol Exp Ther 308:965-974 (Pubitemid 38263972)
111. Kuhle S, Male C, Mitchell L (2003) Developmental hemostasis: Pro- and anticoagulant systems during childhood. Semin Thromb Hemost 29:329-338
112. Läer S, Elshoff JP, Meibohm B, Weil J, Mir TS, Zhang W, Hulpke-Wette M (2005) Development of a safe and effective pediatric dosing regimen for sotalol based on population pharmacokinetics and pharmacodynamics in children with supraventricular tachycardia. J Am Coll Cardiol 46:1322-1330 (Pubitemid 41615557)
113. Lambert GH, Schoeller DA, Kotake AN, Flores C, Hay D (1986) The effect of age, gender, and sexual maturation on the caffeine breath test. Dev Pharmacol Ther 9:375-388 (Pubitemid 17213887)
114. Latasch L, Freye E (2002) Pain and opioids in preterm and newborns. Anaesthesist 51:272-284
115. Lebenthal A, Lebenthal E (1999) The ontogeny of the small intestinal epithelium. JPEN J Parenter Enteral Nutr 23:S3-S6
116. Lenney W, Milner AD (1978) At what age do bronchodilator drugs work? Arch Dis Child 53:532-535 (Pubitemid 8376706)
117. Leonhardt A, Seyberth HW (2003) Do we need another NSAID instead of indomethacin for treatment of ductus arteriosus in preterm infants? Acta Paediatr 92:996-999 (Pubitemid 37239155)
118. Leonhardt A, Glaser A, Wegmann M, Schranz D, Seyberth H, Nusing R (2003) Expression of prostanoid receptors in human ductus arteriosus. Br J Pharmacol 138:655-659 (Pubitemid 36315313)
119. Leonhardt A, Strehl R, Barth H, Seyberth HW (2004) High efficacy and minor renal effects of indomethacin treatment during individualized fluid intake in premature infants with patent ductus arteriosus. Acta Paediatr 93:233-240 (Pubitemid 38230721)
120. Leung DYM (2007) Allergy and the immumologic basis of atopic disease. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
121. Levene M (2007) Minimising neonatal brain injury: How research in the past five years has changed my clinical practice. Arch Dis Child 92:261-265 (Pubitemid 46423802)
122. Linday LA, Engle MA, Reidenberg MM (1981) Maturation and renal digoxin clearance. Clin Pharmacol Ther 30:735-738 (Pubitemid 12198096)
123. Linday LA, Drayer DE, Khan MA, Cicalese C, Reidenberg MM (1984) Pubertal changes in net renal tubular secretion of digoxin. Clin Pharmacol Ther 35:438-446 (Pubitemid 14133481)
124. Litalien C, Theoret Y, Faure C (2005) Pharmacokinetics of proton pump inhibitors in children. Clin Pharmacokinet 44:441-466 (Pubitemid 40733732)
125. Liu AH, Covar RA, Spahn JD, Leung DYM (2007) Childhood asthma. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
126. Liu H, Manganiello V, Waleh N, Clyman RI (2008) Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus. Pediatr Res 64:477-481
127. Löscher W, Klotz U, Zimprich F, Schmidt D (2009) The clinical impact of pharmacogenetics on the treatment of epilepsy. Epilepsia 50:1-23
128. Lowry JA, Jarrett RV, Wasserman G, Pettett G, Kauffman RE (2001) Theophylline toxicokinetics in premature newborns. Arch Pediatr Adolesc Med 155:934-939 (Pubitemid 32729575)
129. Lynn AM, Nespeca MK, Opheim KE, Slattery JT (1993) Respiratory effects of intravenous morphine infusions in neonates, infants, and children after cardiac surgery. Anesth Analg 77:695-701 (Pubitemid 23291882)
130. Madadi P, Ross CJ, Hayden MR, Carleton BC, Gaedigk A, Leeder JS, Koren G (2009) Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: A case-control study. Clin Pharmacol Ther 85:31-35
131. Mandelli M, Tognoni G, Garattini S (1978) Clinical pharmacokinetics of diazepam. Clin Pharmacokinet 3:72-91 (Pubitemid 8287275)
132. Marcell AB, Irwin CE Jr (2003a) Risk-taking behaviors: Substance use and abuse. In: Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Siegel NJ (eds) Rudolph's pediatrics, 21st edn. McGraw Hill Medical, New York
133. Marcell AB, Irwin CE Jr (2003b) Risk-taking behaviors: Unintentional injuries. In: Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Siegel NJ (eds) Rudolph's pediatrics, 21st edn. McGraw Hill Medical, New York
134. Marcell AV, Irwin CE Jr (2003c) Risk-taking behaviors: Sexual behavior. In: Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Siegel NJ (eds) Rudolph's pediatrics, 21st edn. McGraw Hill Medical, New York
135. Marcell AV, Irwin, Jr CE (2003d) Risk-taking behaviors: Covariation of risk behavoirs. In: Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Siegel NJ (eds) Rudolph's Pediatrics, 21st edn. McGraw Hill Medical, New York
136. Marshall JD, Kearns GL (1999) Developmental pharmacodynamics of cyclosporine. Clin Pharmacol Ther 66:66-75 (Pubitemid 29350447)
137. McCracken GH Jr (1986) Aminoglycoside toxicity in infants and children. Am J Med 80:172-178 (Pubitemid 16036784)
138. McIlleron H, Willemse M, Werely CJ, Hussey GD, Schaaf HS, Smith PJ, Donald PR (2009) Isoniazid plasma concentrations in a cohort of South African children with tuberculosis: Implications for international pediatric dosing guidelines. Clin Infect Dis 48:1547-1553
139. Miki Y, Suzuki T, Tazawa C, Blumberg B, Sasano H (2005) Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol Cell Endocrinol 231:75-85 (Pubitemid 40248818)
140. Miller ML (2007) Evaluation of suspected rheumatic disease. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
141. Mirochnick MH, Miceli JJ, Kramer PA, Chapron DJ, Raye JR (1988) Furosemide pharmacokinetics in very low birth weight infants. J Pediatr 112:653-657
142. Momma K, Toyoshima K, Takeuchi D, Imamura S, Nakanishi T (2005a) In vivo reopening of the neonatal ductus arteriosus by a prostanoid EP4-receptor agonist in the rat. Prostaglandins Other Lipid Mediat 78:117-128 (Pubitemid 41636837)
143. Momma K, Toyoshima K, Takeuchi D, Imamura S, Nakanishi T (2005b) In vivo constriction of the fetal and neonatal ductus arteriosus by a prostanoid EP4-receptor antagonist in rats. Pediatr Res 58:971-975 (Pubitemid 41511074)
144. Momma K, Toyoshima K, Ito K, Sugiyama K, Imamura S, Sun F, Nakanishi T (2009) Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat. Neonatology 96:69-79
145. Moscicki AB (2003) Common menstrual problems. In: Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Siegel NJ (eds) Rudolph's pediatrics, 21st edn. McGraw Hill Medical, New York
146. Mulrooney DA, Yeazel MW, Kawashima T, Mertens AC, Mitby P, Stovall M, Donaldson SS, Green DM, Sklar CA, Robison LL, Leisenring WM (2009) Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: Retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ 339:b4606
147. Murry DJ, Crom WR, Reddick WE, Bhargava R, Evans WE (1995) Liver volume as a determinant of drug clearance in children and adolescents. Drug Metab Dispos 23:1110-1116
148. Nakanishi T, Gu H, Hagiwara N, Momma K (1993) Mechanisms of oxygen-induced contraction of ductus arteriosus isolated from the fetal rabbit. Circ Res 72:1218-1228 (Pubitemid 23147605)
149. Narayanan M, Schlueter M, Clyman RI (1999) Incidence and outcome of a 10-fold indomethacin overdose in premature infants. J Pediatr 135:105-107 (Pubitemid 30180572)
150. Natarajan G, Botica ML, Thomas R, Aranda JV (2007) Therapeutic drug monitoring for caffeine in preterm neonates: An unnecessary exercise? Pediatrics 119:936-940 (Pubitemid 46715664)
151. Neu J (2007) Gastrointestinal development and meeting the nutritional needs of premature infants. Am J Clin Nutr 85:629S-634S (Pubitemid 46220974)
152. Nissen SE (2006) ADHD drugs and cardiovascular risk. N Engl J Med 354:1445-1448
153. No authors listed (2004) Morbidity and mortality among outborn neonates at 10 tertiary care institutions in India during the year 2000. J Trop Pediatr 50:170-174
154. Norton ME, Merrill J, Cooper BA, Kuller JA, Clyman RI (1993) Neonatal complications after the administration of indomethacin for preterm labor. N Engl J Med 329:1602-1607 (Pubitemid 23345638)
155. Ohlsson A, Walia R, Shah S (2008) Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev: CD003481
156. Olkkola KT, Maunuksela EL, Korpela R, Rosenberg PH (1988) Kinetics and dynamics of postoperative intravenous morphine in children. Clin Pharmacol Ther 44:128-136
157. Pacifici GM (2009) Clinical pharmacokinetics of aminoglycosides in the neonate: A review. Eur J Clin Pharmacol 65:419-427
158. Paradisis M, Evans N, Kluckow M, Osborn D (2009) Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants. J Pediatr 154:189-195
159. Paus T, Keshavan M, Giedd JN (2008) Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci 9:947-957
160. Peters M, Jeck N, Reinalter S, Leonhardt A, Tonshoff B, Klaus GG, Konrad M, Seyberth HW (2002) Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies. Am J Med 112:183-190
161. Peterson RG, Simmons MA, Rumack BH, Levine RL, Brooks JG (1980) Pharmacology of furosemide in the premature newborn infant. J Pediatr 97:139-143 (Pubitemid 10033785)
162. Pons G, Rey E, Carrier O, Richard MO, Moran C, Badoual J, Olive G (1989) Maturation of AFMU excretion in infants. Fundam Clin Pharmacol 3:589-595 (Pubitemid 20003757)
163. Powers PS, Bruty H (2009) Pharmacotherapy for eating disorders and obesity. Child Adolesc Psychiatr Clin N Am 18:175-187
164. Prevot A, Mosig D, Guignard JP (2002) The effects of losartan on renal function in the newborn rabbit. Pediatr Res 51:728-732 (Pubitemid 34547336)
165. Raishevich N, Jensen P (2007) Attention-deficit/hyperactivity disorder. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
166. Raju TN, Higgins RD, Stark AR, Leveno KJ (2006) Optimizing care and outcome for late-preterm (near-term) infants: A summary of the workshop sponsored by the National Institute of Child Health and Human Development. Pediatrics 118:1207-1214 (Pubitemid 46090065)
167. Ramachandrappa A, Jain L (2009) Health issues of the late preterm infant. Pediatr Clin North Am 56:565-577
168. Rane A (2005) Drug metabolism and disposition in infants and children. Neonatal and pediatric pharmacology - therapeutic principles in practice, 3rd edn. Lippincott Williams and Wilkins, Philadelphia
169. Redmond GP, Bell JJ, Perel JM (1978) Effect of human growth hormone on amobarbital metabolism in children. Clin Pharmacol Ther 24:213-218 (Pubitemid 9022518)
170. Reed MD, Rodarte A, Blumer JL, Khoo KC, Akbari B, Pou S, Pharmd KGL (2001) The singledose pharmacokinetics of midazolam and its primary metabolite
171. Reese J, Waleh N, Poole SD, Brown N, Roman C, Clyman RI (2009) Chronic in utero cyclooxygenase inhibition alters PGE2-regulated ductus arteriosus contractile pathways and prevents postnatal closure. Pediatr Res 66:155-161
172. Reinalter SC, Jeck N, Peters M, Seyberth HW (2004) Pharmacotyping of hypokalaemic salt-losing tubular disorders. Acta Physiol Scand 181:513-521 (Pubitemid 39078849)
173. Roan Y, Galant SP (1982) Decreased neutrophil beta adrenergic receptors in the neonate. Pediatr Res 16:591-593 (Pubitemid 12093504)
174. Rodrigues AD (2005) Impact of CYP2C9 genotype on pharmacokinetics: Are all cyclooxygenase inhibitors the same? Drug Metab Dispos 33:1567-1575 (Pubitemid 41541940)
175. Sankar R, Painter MJ (2005) Neonatal seizures: After all these years we still love what doesn't work. Neurology 64:776-777 (Pubitemid 40316310)
176. Sans V, de la Dumas RE, Berge J, Grenier N, Boralevi F, Mazereeuw-Hautier J, Lipsker D, Dupuis E, Ezzedine K, Vergnes P, Taieb A, Leaute-Labreze C (2009) Propranolol for severe infantile hemangiomas: Follow-up report. Pediatrics 124:e423-e431
177. Satwani P, Morris E, van de Ven C, Cairo MS (2005) Dysregulation of expression of immunoregulatory and cytokine genes and its association with the immaturity in neonatal phagocytic and cellular immunity. Biol Neonate 88:214-227 (Pubitemid 41433554)
178. Schindler M (2002) Do bronchodilators have an effect on bronchiolitis? Crit Care 6:111-112 (Pubitemid 34296336)
179. Schuster V, von Stockhausen HB, Seyberth HW (1990) Effects of highly overdosed indomethacin in a preterm infant with symptomatic patent ductus arteriosus. Eur J Pediatr 149:651-653 (Pubitemid 20211569)
180. Seyberth HW (2008) An improved terminology and classification of Bartter-like syndromes. Nat Clin Pract Nephrol 4:560-567
181. Seyberth HW, Kühl PG (1988) The role of eicosanoids in paediatrics. Eur J Pediatr 147:341-349
182. Seyberth HW, Rascher W, Hackenthal R, Wille L (1983) Effect of prolonged indomethacin therapy on renal function and selected vasoactive hormones in very-low-birth-weight infants with symptomatic patent ductus arteriosus. J Pediatr 103:979-984 (Pubitemid 14204205)
183. Seyberth HW, Müller H, Ulmer HE, Wille L (1984) Urinary excretion rates of 6-keto-PGF1 alpha in preterm infants recovering from respiratory distress with and without patent ductus arteriosus. Pediatr Res 18:520-524 (Pubitemid 14120029)
184. Seyberth HW, Leonhardt A, Tönshoff B, Gordjani N (1991) Prostanoids in paediatric kidney diseases. Pediatr Nephrol 5:639-649
185. Shankaran S, Kauffman RE (1984) Use of chloramphenicol palmitate in neonates. J Pediatr 105:113-116 (Pubitemid 14086284)
186. Shirkey HC (1975) Pediatric therapy, 5th edn. The C.V. Mosby Company, Saint Louis
187. Sjöqvist F, Garle M, Rane A (2008) Use of doping agents, particularly anabolic steroids, in sports and society. Lancet 371:1872-1882 (Pubitemid 351734542)
188. Slotkin TA, Auman JT, Seidler FJ (2003) Ontogenesis of beta-adrenoceptor signaling: Implications for perinatal physiology and for fetal effects of tocolytic drugs. J Pharmacol Exp Ther 306:1-7 (Pubitemid 36734350)
189. Smith GC (1998) The pharmacology of the ductus arteriosus. Pharmacol Rev 50:35-58
190. Smith GC, McGrath JC (1994) Interactions between indomethacin, noradrenaline and vasodilators in the fetal rabbit ductus arteriosus. Br J Pharmacol 111:1245-1251 (Pubitemid 24148798)
191. Smith GC, Wu WX, Nijland MJ, Koenen SV, Nathanielsz PW (2001) Effect of gestational age, corticosteroids, and birth on expression of prostanoid EP receptor genes in lamb and baboon ductus arteriosus. J Cardiovasc Pharmacol 37:697-704 (Pubitemid 32480438)
192. Steer PA, Henderson-Smart DJ (2000) Caffeine versus theophylline for apnea in preterm infants. Cochrane Database Syst Rev: CD000273
193. Stevens TP, Harrington EW, Blennow M, Soll RF (2007) Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome. Cochrane Database Syst Rev: CD003063
194. Stewart CF, Hampton EM (1987) Effect of maturation on drug disposition in pediatric patients. Clin Pharm 6:548-564 (Pubitemid 17114067)
195. Strolin BM, Whomsley R, Baltes EL (2005) Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations. Expert Opin Drug Metab Toxicol 1:447-471
196. Subbarao P, Ratjen F (2006) Beta2-agonists for asthma: The pediatric perspective. Clin Rev Allergy Immunol 31:209-218
197. Szabó EZ, Luginbuehl I, Bissonnette B (2009) Impact of anesthetic agents on cerebrovascular physiology in children. Paediatr Anaesth 19:108-118
198. Taddio A, Katz J, Ilersich AL, Koren G (1997) Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet 349:599-603 (Pubitemid 27101886)
199. Takahashi H, Ishikawa S, Nomoto S, Nishigaki Y, Ando F, Kashima T, Kimura S, Kanamori M, Echizen H (2000) Developmental changes in pharmacokinetics and pharmacodynamics of warfarin enantiomers in Japanese children. Clin Pharmacol Ther 68:541-555
200. Tanner JM, Davies PS (1985) Clinical longitudinal standards for height and height velocity for North American children. J Pediatr 107:317-329 (Pubitemid 15240782)
201. Thébaud B, Michelakis ED, Wu XC, Moudgil R, Kuzyk M, Dyck JR, Harry G, Hashimoto K, Haromy A, Rebeyka I, Archer SL (2004) Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: Implications for infants with patent ductus arteriosus. Circulation 110:1372-1379 (Pubitemid 39238014)
202. Thompson AM, Bizzarro MJ (2008) Necrotizing enterocolitis in newborns: Pathogenesis, prevention and management. Drugs 68:1227-1238 (Pubitemid 351822112)
203. Tobin JR (2008) Paradoxical effects of midazolam in the very young. Anesthesiology 108:6-7
204. Toyoshima K, Momma K, Imamura S, Nakanishi T (2006) In vivo dilatation of the fetal and postnatal ductus arteriosus by inhibition of phosphodiesterase 3 in rats. Biol Neonate 89:251-256 (Pubitemid 43886937)
205. Tubergen DG, Bleyer A (2007) The leukemias. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia
206. Vogelstein B, Kowarski A, Lietman PS (1977) The pharmacokinetics of amikacin in children. J Pediatr 91:333-339 (Pubitemid 8152140)
207. Waleh N, Kajino H, Marrache AM, Ginzinger D, Roman C, Seidner SR, Moss TJ, Fouron JC, Vazquez-Tello A, Chemtob S, Clyman RI (2004) Prostaglandin E2 - mediated relaxation of the ductus arteriosus: Effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control. Circulation 110:2326-2332 (Pubitemid 39407334)
208. Waleh N, Reese J, Kajino H, Roman C, Seidner S, McCurnin D, Clyman RI (2009) Oxygeninduced tension in the sheep ductus arteriosus: Effects of gestation on potassium and calcium channel regulation. Pediatr Res 65:285-290
209. Walker SM, Franck LS, Fitzgerald M, Myles J, Stocks J, Marlow N (2009) Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm. Pain 141:79-87
210. Wang L, Pozzato V, Turato G, Madamanchi A, Murphy TM, Chitano P (2008) Reduced spontaneous relaxation in immature guinea pig airway smooth muscle is associated with increased prostanoid release. Am J Physiol Lung Cell Mol Physiol 294:L964-L973
211. Wheatley CM, Dickinson JL, Mackey DA, Craig JE, Sale MM(2002) Retinopathy of prematurity: Recent advances in our understanding. Br J Ophthalmol 86:696-700 (Pubitemid 34627966)
212. Whitsett JA, Noguchi A, Moore JJ (1982) Developmental aspects of alpha- and beta-adrenergic receptors. Semin Perinatol 6:125-141
213. Witter FR, Zimmerman AW, Reichmann JP, Connors SL (2009) In utero beta 2 adrenergic agonist exposure and adverse neurophysiologic and behavioral outcomes. Am J Obstet Gynecol 201:553-559
214. Wright DH, Abran D, Bhattacharya M, Hou X, Bernier SG, Bouayad A, Fouron JC, Vazquez-Tello A, Beauchamp MH, Clyman RI, Peri K, Varma DR, Chemtob S (2001) Prostanoid receptors: Ontogeny and implications in vascular physiology. Am J Physiol Regul Integr Comp Physiol 281:R1343-R1360
215. Yaffe SJ, Friedman WF, Rogers D, Lang P, Ragni M, Saccar C (1980) The disposition of indomethacin in preterm babies. J Pediatr 97:1001-1006 (Pubitemid 11209394)
216. Yang D, Pearce RE, Wang X, Gaedigk R, Wan YJ, Yan B (2009) Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Biochem Pharmacol 77:238-247