Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 21, 2011, Pages 6182-6195

  Shen, Li ^a   Park, Eun Jung ^a   Kondratyuk, Tamara P ^a   Guendisch, Daniela ^a   Marler, Laura ^a   Pezzuto, John M ^a   Wright, Anthony D ^a   Sun, Dianqing ^a  

^a UNIVERSITY OF HAWAII AT HILO   (United States)

Author keywords

1inos; anticancer agent; aromatase; atetrahydro carboline; callophycin; chemoprevention; nfjb; quinone reductase

Indexed keywords

2 (4 BROMOPHENYLSULFONYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 (ALLYLOXYCARBONYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 (CYCLOPROPYLMETHYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 (ISOBUTOXYCARBONYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 (METHYLSULFONYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 (PROP 2 YNYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 ALLYL 3 METHYL 3,4 DIHYDRO 1H PYRIDO[3,4 B]INDOLE 2,3(9H) DICARBOXYLATE; 2 BENZYL 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 ISOBUTYL 3 METHYL 3,4 DIHYDRO 1H PYRIDO[3,4 B]INDOLE 2,3(9H) DICARBOXYLATE; 2 TOSYL 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; AROMATASE; CALLOPHYCIN A DERIVATIVE; METHYL 2 (1 ADAMANTYLCARBAMOYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (4 BROMOPHENYLSULFONYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (4 HYDROXYBENZYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (CYCLOHEXYLCARBAMOYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (CYCLOPROPYLMETHYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (ISOPROPYLCARBAMOYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (METHYLSULFONYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (PENTYLCARBAMOYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (PHENETHYLCARBAMOYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 (PROP 2 YNYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 BENZYL 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 TOSYL 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [4 (BENZYLOXY)BENZYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG FORMULATION; DRUG POTENCY; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESTERIFICATION; HUMAN; HUMAN CELL; IC 50; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PROCESS OPTIMIZATION; PROTEIN INDUCTION; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

CALLOPHYCUS OPPOSITIFOLIUS;

EID: 80054926232     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.020     Document Type: Article

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