Design, synthesis and cardioprotective effect of a new class of dual-acting agents: Phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6909-6919

  Bi, Wei ^a   Cai, Jianhui ^a   Liu, Sanguang ^a   Baudy Floc'h, Michèle ^c   Bi, Lanrong ^b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b MICHIGAN TECHNOLOGICAL UNIVERSITY   (United States)

^c UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Antithrombotic agent; Dual acting agents; Free radicals scavenger; Phenolic tetrahydro carboline RGD peptidomimetics conjugates

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; ARGINYLGLYCYLASPARTIC ACID; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTITHROMBOTIC ACTIVITY; ARTERY THROMBOSIS; ARTICLE; CELL STRAIN; CELL SURVIVAL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SYNTHESIS; EXPERIMENTAL RAT; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OXIDATION; RAT; THROMBOCYTE AGGREGATION; VASODILATATION;

ANIMALS; CARBOLINES; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FIBRINOLYTIC AGENTS; FREE RADICAL SCAVENGERS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PC12 CELLS; PHENOL; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; THROMBOSIS;

RATTUS;

EID: 34548863361     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.022     Document Type: Article

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