Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-β-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1745-1750

  Düsman Tonin, Lilian T ^a   Barbosa, Valéria A ^a   Bocca, Cleverson Cassero ^a   Ramos, Érika R F ^a   Nakamura, Celso V ^a   Ferreira da Costa, Willian ^a   Basso, Ernani A ^a   Nakamura, Tânia U ^a   Sarragiotto, Maria Helena ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Cyclic voltammetry; Tetrahydro carbolines; Theoretical calculations; Trypanosoma cruzi

Indexed keywords

ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; CIS METHYL 1 (3 NITROPHENYL) 1,2,3,4 TETRAHYDRO 9H BETA CARBOLINE 3 CARBOXYLATE; CIS METHYL 1 (4 NITROPHENYL) 1,2,3,4 TETRAHYDRO 9H BETA CARBOLINE 3 CARBOXYLATE; TRANS METHYL 1 (3 NITROPHENYL) 1,2,3,4 TETRAHYDRO 9H BETA CARBOLINE 3 CARBOXYLATE; TRANS METHYL 1 (4 NITROPHENYL) 1,2,3,4 TETRAHYDRO 9H BETA CARBOLINE 3 CARBOXYLATE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DRUG CONFORMATION; DRUG DETERMINATION; DRUG SYNTHESIS; ELECTROCHEMICAL DETECTION; IC 50; IN VITRO STUDY; ISOMER; NONHUMAN; TRYPANOSOMA CRUZI;

ANIMALS; CARBOXYLIC ACIDS; ELECTROCHEMISTRY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITROIMIDAZOLES; STATIC ELECTRICITY; STEREOISOMERISM; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 61349112113     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.03.044     Document Type: Article

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