Cancer chemopreventive and anticancer evaluation of extracts and fractions from marine macro- and microorganisms collected from twilight zone waters around Guam

Natural Product Communications

Volumn 4, Issue 12, 2009, Pages 1717-1728

  Schupp, Peter J ^a,c   Kohlert Schupp, Claudia ^a   Whitefield, Susanna ^a   Engemann, Anna ^a   Rohde, Sven ^a   Hemscheidt, Thomas ^c   Pezzuto, John M ^b,c   Kondratyuk, Tamara P ^b   Park, Eun Jung ^b   Marler, Laura ^b   Rostama, Bahman ^b   Wright, Anthony D ^b,c  

^a UNIVERSITY OF GUAM   (Guam)

^b UNIVERSITY OF HAWAII AT HILO   (United States)

^c UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Anticancer; Aromatase; Chemoprevention; DPPH; Extracts; Fractions; Guam; Marine organisms; MCF 7 and HL 60 proliferation; Micro organisms; Nf B; Nitric oxide synthase; Quinone reductase; RXR; Twilight zone

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTINEOPLASTIC AGENT; AROMATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHANOL; NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; QUINONE DERIVATIVE; RETINOID X RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; WATER; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; ANTIOXIDANT; AROMATASE INHIBITOR; BIPHENYL DERIVATIVE; COLORING AGENT; PICRIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SEA WATER; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIUM; BIOASSAY; CANCER CELL; CANCER INHIBITION; CELL FRACTIONATION; CELL PROLIFERATION; CELL SURVIVAL; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CORAL; CYTOTOXICITY; DRUG INHIBITION; GORGONIAN; GROWTH INHIBITION; GUAM; HUMAN; HUMAN CELL; MARINE SPECIES; NONHUMAN; PURIFICATION; SPONGE (PORIFERA); ANIMAL; ANTHOZOA; BIOLOGY; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MICROBIOLOGY;

ANTHOZOA; BACTERIA (MICROORGANISMS); GORGONACEA; SUBEREA;

ANIMALS; ANTHOZOA; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; AROMATASE INHIBITORS; BACTERIA; BIPHENYL COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORING AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; GUAM; MARINE BIOLOGY; NAD(P)H DEHYDROGENASE (QUINONE); NF-KAPPA B; PICRATES; PORIFERA; RETINOID X RECEPTORS; SEAWATER; TETRAZOLIUM SALTS; THIAZOLES; WATER MICROBIOLOGY;

EID: 77649264841     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. th Annual Meeting of the American Society of Pharmacology Meeting, June 27-July 1, Honolulu, Hawaii, Congress Abstract, P-416.
2. MarinLit, Version 2008. A marine literature database produced and maintained by the Department of Chemistry, University of Canterbury, New Zealand.
3. McClintock JB, Baker BJ (2001) Marine Chemical Ecology. CRC Press, Boca Raton, USA.
4. Proksch P, Ebel R, Edrada RA, Wray V, Steube K. (2003) Bioactive natural products from marine invertebrates and associated fungi. In: Sponges (Porifera). Müller WEG (Ed.). Springer-Verlag, Berlin, 117-142.
5. Faulkner DJ. (2000) Marine pharmacology. Antonie Van Leeuwenhoek, 77, 135-145.
6. Wright AD, McCluskey A, Macgregor K, Guenther J. (2008) Potential ecological role, chemistry and molecular modeling studies of secondary metabolites isolated from the tropical marine sponge Cymbastela hooperi. Planta Medica, 74, 931.
7. McKee TC, Cardellina JH, Riccio R, Dauria MV, Iorizzi M, Minale L, Moran RA, Gulakowski RJ, Buckheit RW, Snader KM, Boyd MR. (1994) HIV-inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates. Journal of Medicinal Chemistry, 37, 793-797.
8. Coulson FR, O'Donnell SR. (2000) The effects of contignasterol (IZP-94,005) on allergen-induced plasma protein exudation in the tracheobronchial airways of sensitized guinea-pigs in vivo. Inflammation Research, 49, 123-127.
9. Kikuchi A, Nieda M, Schmidt C, Koezuka Y, Ishihara S, Ishikawa Y, Tadokoro K, Durrant S, Boyd A, Juji T, Nicol A. (2001) In vitro anti-tumour activity of α-galactosylceramidestimulated human invariant Vα24+NKT cells against melanoma. British Journal of Cancer, 85, 741-746.
10. Faulkner DJ, Harper MK, Haygood MG, Salomon CE, Schmidt EW. (2000) Symbiotic bacteria in sponges: sources of bioactive substances. In: Drugs from the Sea. Fusetani N. (Ed.). Karger, Basel. 107-119.
11. Munro MHG, Blunt JW, Lake RJ, Litaudon M, Battershill CN, Page MJ. (1994) From seabed to sickbed: What are the prospects? In: Sponges in time and space. Van Soest RWM, van Kempen TMG, Braekman JC. (Eds). AA Balkema, Rotterdam, Netherlands, 473-484.
12. Pomponi SA, Willoughby R (1994) Sponge cell culture for production of bioactive metabolites. In: Sponges in time and space. Van Soest RWM, van Kempen TMG, Braekman, JC. (Eds.). AA Balkema, Rotterdam, Netherlands. 395-400.
13. Osinga R, Tramper J, Wijffels RH. (1998) Cultivation of marine sponges for metabolite production: applications for biotechnology? Trends in Biotechnology, 16, 130-134.
14. Blackhall FH, Ranson M, Radford JA, Hancock BW, Soukop M, McGown AT, Robbins A, Halbert G, Jayson GC. (2001) A phase II trial of bryostatin 1 in patients with non-Hodgkin's lymphoma. British Journal of Cancer, 84, 465-469.
15. Lopanik N, Lindquist N, Targett N. (2004) Potent cytotoxins produced by a microbial symbiont protect host larvae from predation. Oecologia, 139, 131-139. (Pubitemid 38503659)
16. Haygood MG, Davidson SK. (1997) Small-subunit rRNA genes and in-situ hybridization with oligonucleotides specific for bacterial symbionts in larvae of the bryozoan Bugula neritina and proposal of "Candidatus Endobugula sertula". Applied Environmental Microbiology, 63, 4612-4616.
17. Proksch P, Edrada RA, Ebel R. (2002) Drugs from the seas: Current status and microbiological implications. Applied Microbiology and Biotechnology, 59, 125-134.
18. Thoms C, Schupp PJ. (2005) Biotechnological potential of marine sponges and their associated bacteria as producers of new pharmaceuticals (Part II). Journal of International Biotechnology Law, 2, 257-264.
19. Thoms C, Schupp PJ. (2005) Biotechnological potential of marine sponges and their associated bacteria as producers of new pharmaceuticals (Part I). Journal of International Biotechnology Law, 2, 217-220.
20. Vacelet J. (1975) Étude en microscopie électronique de l'association entre bactéries et spongiaires du genre Verongia (Dictyoceratida). Journal of Microscopy and Biology of the Cell, 23, 271-288.
21. Bewley CA, Faulkner DJ. (1998) Lithistid sponges: Star performers or hosts to the stars? Angewandte Chemie International Edition, 37, 2162-2178.
22. Salomon CE, Deerinck T, Ellisman MH, Faulkner DJ. (2001) The cellular localization of dercitamide in the Palauan sponge Oceanapia sagittaria. Marine Biology, 139, 313-319.
23. Bewley CA, Holland ND, Faulkner DJ. (1996) Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts. Experientia, 52, 716-722.
24. Schmidt EW, Obraztsova AY, Davidson SK, Faulkner DJ, Haygood MG. (2000) Identification of the antifungal peptide-containing symbiont of the marine sponge T. swinhoei as a novel deltaproteobacterium, "Candidatus Entotheonella palauensis". Marine Biology, 136, 969-977.
25. Burja AM, Hill RT. (2001) Microbial symbionts of the Australian Great Barrier Reef sponge, Candidaspongia flabellata. Hydrobiologia, 461, 41-47.
26. Kerr RG. (2000) Biosynthesis of bioactive marine natural products. In: Studies in Natural Products Chemistry. Vol. 21. Atta-ur- Rahman (Ed.). Elsevier, Amsterdam. 293-328.
27. Steinert M, Hentschel U, Hacker J. (2000) Symbiosis and pathogenesis: Evolution of the microbe-host interaction. Naturwissenschaften, 87, 1-11. (Pubitemid 30058783)
28. Hentschel U, Fieseler L, Wehrl M, Gernert C, Steinert M, Hacker J, Horn M. (2003) Microbial diversity of marine sponges. In: Sponges (Porifera). Müller WEG. (Ed.). Springer-Verlag. 59-88.
29. Santiago-Vazquez LZ, Brueck T, Brueck WM, Duque-Alarcon AP, McCarthy PJ, Kerr RG. (2007) The diversity of the bacterial communities associated with the azooxanthellate hexacoral Cirrhipathes lutkeni. The ISME Journal, 1, 654-659.
30. Laird SA, ten Kate K. (1999) In: The Commercial Use of Biodiversity. Access to Genetic Resources and Benefit-Sharing, ten Kate K, Laird SA. (Eds.). Earthscan Publications, London. 34-77.
31. Cragg GM, Newman DJ. (2005) International collaboration in drug discovery and development from natural sources. Pure and Applied Chemistry, 77, 1923-1942.
32. Cragg GM, Newman DJ, Yang SS. (2006) Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience. Journal of Natural Products, 69, 488-498.
33. Wu K, Kim HT, Rodriquez JL, Hilsenbeck SG, Mohsin SK, Xu XC, Lamph WW, Kuhn JG, Green JE, Brown PH. (2002) Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069. Cancer Epidemiology Biomarkers and Prevention, 11, 467-474.
34. Kang Y-H, Pezzuto, JM. (2004) Induction of quinone reductase as a primary screen for natural product anticarcinogens. In: Quinones and Quinone Enzymes (A Volume of Methods in Enzymology), Sies H, Packer L (Eds.), Elsevier Science, San Diego, California, USA. 380-414.
35. Lubet RA, Steele VE, Casebolt TL, Eto I, Kelloff GJ, Grubbs CJ. (1994) Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostendione in the methylnitrosourea (MNU)-induced mammary tumor model in Spague- Dawley rats. Carcinogenesis, 15, 2775-2780.
36. Gubson DE, Steele RE, Chau RY. (1995) Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. British Journal of Cancer, 72, 72-75.
37. Crowell JA, Steele VE, Sigman CC, Fay JR. (2003) Is inducible nitric oxide synthase a target for chemoprevention? Molecular Cancer Therapy, 2, 815-823.
38. Pezzuto, JM, Kosmeder II, JW, Park, EJ, Lee, SK, Cuendet, M, Gills, J, Bhat, K, Grubjesic, S, Park, H-S, Mata-Greenwood, E, Tan, YM, Yu, R, Lantvit, DD, Kinghorn, AD. (2005) Characterization of Natural Product Chemopreventive Agents. In: Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention, Kelloff GJ, Hawk ET, Sigman CC. (Eds.), Humana Press Inc., Totowa, New Jersey, USA. 3-37.
39. Francy-Guilford, J, Pezzuto, JM. (2008) Mechanisms of cancer chemopreventive agents: A perspective. Planta Medica, 74, 1644-1650.
40. Homhual S, Bunyapraphatsara N, Kondratyuk TP, Herunsalee A, Chaukul W, Pezzuto JM, Fong HS, Zhang HJ. (2006) Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza. Journal of Natural Products, 69, 421-424.
41. Magalhães LM, Segundo MA, Reis S, Lima JL. (2008) Methodological aspects about in vitro evaluation of antioxidant properties. Analytica Chimica Acta, 613, 1-19.
42. Lee SK, Mbwambo ZH, Chung H, Luyengi L, Gamez EJ, Mehta RG, Kinghorn AD, Pezzuto JM.(1998) Evaluation of the antioxidant potential of natural products. Combinatorial Chemistry and High Throughput Screening, 1, 35-46.
43. Tanaka T, Suh KS, Lo AM, De Luca LM. (2007) p21WAF1/CIP1 is a common transcriptional target of retinoid receptors: pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer. Journal of Biological Chemistry, 282, 29987-29997.
44. Su BN, Gu JQ, Kang YH, Park EJ, Pezzuto JM, Kinghorn AD. (2004) Induction of the phase II enzyme, quinone reductase, by withanolides and norwithanolides from Solanaceous species. Mini-Reviews in Organic Chemistry, 1, 115-123.
45. Maiti A, Cuendet M, Croy VL, Endringer DC, Pezzuto JM, Cushman M. (2007) Synthesis and biological evaluation of (+/-)- abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. Journal of Medicinal Chemistry, 50, 2799-2806.
46. Kim Y, Min HY, Park HJ, Lee EJ, Park EJ, Hwang HJ, Jin C, Lee YS, Lee SK. (2004) Suppressive effects of nitric oxide production and inducible nitric oxide synthase (iNOS) gene expression by Calystegia soldanella methanol extract on lipopolysaccharide-activated RAW 264.7 cells. European Journal of Cancer Prevention, 13, 419-424.
47. Lee EJ, Min HY, Chung HJ, Park EJ, Shin DH, Jeong LS, Lee SK. (2005) A novel adenosine analog, thio-Cl-IB-MECA, induces G0/G1 cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Biochemistry and Pharmacology, 70, 918-924.
48. You M, Wickramaratne DB, Silva GL, Chai H, Chagwedera TE, Farnsworth NR, Cordell GA, Kinghorn AD, Pezzuto JM. (1995) Roemerine, an aporphine alkaloid from Annona senegalensis that reverses the multidrug-resistance phenotype with cultured cells. Journal of Natural Products, 58, 598-604.