Core binding factor beta functions in the maintenance of stem cells and orchestrates continuous proliferation and differentiation in mouse incisors

Stem Cells

Volumn 29, Issue 11, 2011, Pages 1792-1803

  Kurosaka, Hiroshi ^a   Islam, Nurul ^a   Kuremoto, Koh Ichi ^b   Hayano, Satoru ^a   Nakamura, Masahiro ^a   Kawanabe, Noriaki ^a   Yanagita, Takeshi ^a   Rice, David P C ^c   Harada, Hidemitsu ^d   Taniuchi, Ichiro ^e   Yamashiro, Takashi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b OSAKA DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF HELSINKI   (Finland)

^d IWATE MEDICAL UNIVERSITY   (Japan)

^e RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

Conditional knockout; Cre loxP system; Developmental biology; Differentiation; Stem cell microenvironment interactions; Tissue specific stem cells

Indexed keywords

CORE BINDING FACTOR BETA; MUTANT PROTEIN; TRANSCRIPTION FACTOR RUNX;

AMELOBLAST; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; ENAMEL; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE FUNCTION; INCISOR; KNOCKOUT MOUSE; MESENCHYME; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEM CELL; TOOTH DEVELOPMENT;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CORE BINDING FACTOR ALPHA SUBUNITS; CORE BINDING FACTOR BETA SUBUNIT; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 3; FIBROBLAST GROWTH FACTOR 9; HEDGEHOG PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INCISOR; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; X-RAY MICROTOMOGRAPHY;

MUS; RODENTIA;

EID: 80054915852     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.722     Document Type: Article

References (66)

1. Thesleff I. Genetic basis of tooth development and dental defects. Acta Odontol Scand 2000;58:191-194.
2. Thesleff I. The genetic basis of tooth development and dental defects. Am J Med Genet A 2006;140:2530-2535. (Pubitemid 44868119)
3. Thesleff I, Aberg T. Molecular regulation of tooth development. Bone 1999;25:123-125. (Pubitemid 29322075)
4. Harada H, Kettunen P, Jung HS et al. Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J Cell Biol 1999;147:105-120. (Pubitemid 30211800)
5. Fukumoto S, Kiba T, Hall B et al. Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. J Cell Biol 2004;167:973-983. (Pubitemid 39628119)
6. Thesleff I, Mikkola M. The role of growth factors in tooth development. Int Rev Cytol 2002;217:93-135. (Pubitemid 34498931)
7. Mitsiadis TA, Barrandon O, Rochat A et al. Stem cell niches in mammals. Exp Cell Res 2007;313:3377-3385. (Pubitemid 47404556)
8. Harada H, Toyono T, Toyoshima K et al. FGF10 maintains stem cell population during mouse incisor development. Connect Tissue Res 2002;43:201-204. (Pubitemid 34777925)
9. Harada H, Toyono T, Toyoshima K et al. FGF10 maintains stem cell compartment in developing mouse incisors. Development 2002;129:1533-1541. (Pubitemid 34874173)
10. Speck NA, Terryl S. A new transcription factor family associated with human leukemias. Crit Rev Eukaryot Gene Expr 1995;5:337-364. (Pubitemid 26066879)
11. Tang L, Guo B, Javed A et al. Crystal structure of the nuclear matrix targeting signal of the transcription factor acute myelogenous leukemia-1/polyoma enhancer-binding protein 2alphaB/core binding factor alpha2. J Biol Chem 1999;274:33580-33586. (Pubitemid 129511669)
12. Levanon D, Negreanu V, Bernstein Y et al. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization genomics 1994;23:425-432.
13. Growney JD, Shigematsu H, Li Z et al. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood 2005;106:494-504. (Pubitemid 40981243)
14. Ducy P, Zhang R, Geoffroy V et al. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 1997;89:747-754. (Pubitemid 27516177)
15. Komori T, Yagi H, Nomura S et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997;89:755-764. (Pubitemid 27516178)
16. Inoue K, Ozaki S, Shiga T et al. Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci 2002;5:946-954.
17. Levanon D, Bettoun D, Harris-Cerruti C et al. The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J 2002;21:3454-3463. (Pubitemid 34760577)
18. Li QL, Ito K, Sakakura C et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 2002;109:113-124. (Pubitemid 34327521)
19. Levanon D, Glusman G, Bangsow T et al. Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1. Gene 2001;262:23-33. (Pubitemid 32155331)
20. Yamashiro T, Aberg T, Levanon D et al. Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech Dev 2002 119(suppl 1):S107-110. (Pubitemid 39658695)
21. Karsenty G. Role of Cbfa1 in osteoblast differentiation and function. Semin Cell Dev Biol 2000;11:343-346. (Pubitemid 32096083)
22. Aberg T, Wang XP, Kim JH et al. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 2004;270:76-93. (Pubitemid 38596930)
23. Osorio KM, Lee SE, McDermitt DJ et al. Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation. Development 2008;135:1059-1068. (Pubitemid 351578134)
24. Sasaki K, Yagi H, Bronson RT et al. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. Proc Natl Acad Sci USA 1996;93:12359-12363. (Pubitemid 26367148)
25. Wang Q, Stacy T, Miller JD et al. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell 1996;87:697-708. (Pubitemid 26386943)
26. Dassule HR, Lewis P, Bei M et al. Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 2000;127:4775-4785.
27. Naoe Y, Setoguchi R, Akiyama K et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med 2007;204:1749-1755. (Pubitemid 47236313)
28. Colvin JS, White AC, Pratt SJ et al. Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development 2001;128:2095-2106. (Pubitemid 32600470)
29. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999;21:70-71. (Pubitemid 29036285)
30. North T, Gu TL, Stacy T et al. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development 1999;126:2563-2575. (Pubitemid 29299024)
31. Iseki S, Wilkie AO, Heath JK et al. Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2. Development 1997;124:3375-3384. (Pubitemid 27440452)
32. Nakao K, Morita R, Saji Y et al. The development of a bioengineered organ germ method. Nat Methods 2007;4:227-230. (Pubitemid 46358872)
33. Kurosaka H, Takano-Yamamoto T, Yamashiro T et al. Comparison of molecular and cellular events during lower jaw regeneration of newt (Cynops pyrrhogaster) and West African clawed frog (Xenopus tropicalis). Dev Dyn 2008;237:354-365. (Pubitemid 351312108)
34. Yanagita T, Kubota S, Kawaki H et al. Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. FEBS J 2007;274:1655-1665. (Pubitemid 46426900)
35. Wang XP, Suomalainen M, Jorgez CJ et al. Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell 2004;7:719-730. (Pubitemid 39462692)
36. Kanatani N, Fujita T, Fukuyama R et al. Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development. Dev Biol 2006;296:48-61. (Pubitemid 44061753)
37. Kundu M, Javed A, Jeon JP et al. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet 2002;32:639-644. (Pubitemid 35435177)
38. Kettunen P, Karavanova I, Thesleff I. Responsiveness of developing dental tissues to fibroblast growth factors: Expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9. Dev Genet 1998;22:374-385. (Pubitemid 28309091)
39. Klein OD, Lyons DB, Balooch G et al. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development 2008;135:377-385. (Pubitemid 351228429)
40. Wang XP, Suomalainen M, Felszeghy S et al. An integrated gene regulatory network controls stem cell proliferation in teeth. PLoS Biol 2007;5:e159.
41. Koyama E, Wu C, Shimo T et al. Chick limbs with mouse teeth: An effective in vivo culture system for tooth germ development and analysis. Dev Dyn 2003;226:149-154. (Pubitemid 36043473)
42. Seidel K, Ahn CP, Lyons D et al. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development 2010;137:3753-3761.
43. Takahashi S, Kawashima N, Sakamoto K et al. Differentiation of an ameloblast-lineage cell line (ALC) is induced by Sonic hedgehog signaling. Biochem Biophys Res Commun 2007;353:405-411. (Pubitemid 46014577)
44. Fukumoto S, Yamada A, Nonaka K et al. Essential roles of ameloblastin in maintaining ameloblast differentiation and enamel formation. Cells Tissues Organs 2005;181:189-195.
45. Gibson CW, Yuan ZA, Hall B et al. Amelogenin-deficient mice display an amelogenesis imperfecta phenotype. J Biol Chem 2001;276:31871-31875.
46. Hatakeyama J, Fukumoto S, Nakamura T et al. Synergistic roles of amelogenin and ameloblastin. J Dent Res 2009;88:318-322.
47. Hatakeyama J, Sreenath T, Hatakeyama Y et al. The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice. J Biol Chem 2003;278:35743-35748. (Pubitemid 37102350)
48. Parsa S, Kuremoto K, Seidel K et al. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development 2010;137:3743-3752.
49. Okuda T, Cai Z, Yang S et al. Expression of a knocked-in AML1- ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. Blood 1998;91:3134-3143. (Pubitemid 28193861)
50. Wang Q, Stacy T, Binder M et al. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 1996;93:3444-3449. (Pubitemid 26125639)
51. Lee J, Ahnn J, Bae SC. Homologs of RUNX and CBF beta/PEBP2 beta in C. elegans. Oncogene 2004;23:4346-4352. (Pubitemid 38758601)
52. Kagoshima H, Nimmo R, Saad N et al. The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal. Development 2007;134:3905-3915. (Pubitemid 350187349)
53. Kagoshima H, Sawa H, Mitani S et al. The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell. Dev Biol 2005;287:262-273. (Pubitemid 41636763)
54. Raveh E, Cohen S, Levanon D et al. Dynamic expression of Runx1 in skin affects hair structure. Mech Dev 2006;123:842-850. (Pubitemid 44709502)
55. Kettunen P, Laurikkala J, Itaranta P et al. Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Dev Dyn 2000;219:322-332.
56. Kettunen P, Thesleff I. Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis. Dev Dyn 1998;211:256-268. (Pubitemid 28150609)
57. Lin Y, Cheng YS, Qin C et al. FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors. Dev Dyn 2009;238:324-330.
58. del Moral PM, De Langhe SP, Sala FG et al. Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev Biol 2006;293:77-89.
59. DiNapoli L, Batchvarov J, Capel B. FGF9 promotes survival of germ cells in the fetal testis. Development 2006;133:1519-1527. (Pubitemid 43732965)
60. Gritli-Linde A, Bei M, Maas R et al. Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 2002;129:5323-5337. (Pubitemid 36040329)
61. D'souza RN, Aberg T, Gaikwad J et al. Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 1999;126:2911-2920.
62. Lee HK, Lee DS, Ryoo HM et al. The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20. J Cell Biochem 2010;111:755-767.
63. Aberg T, Cavender A, Gaikwad JS et al. Phenotypic changes in dentition of Runx2 homozygote-null mutant mice. J Histochem Cytochem 2004;52:131-139. (Pubitemid 38032140)
64. Li W, Gibson CW, Abrams WR et al. Reduced hydrolysis of amelogenin may result in X-linked amelogenesis imperfecta. Matrix Biol 2001;19:755-760.
65. Kim JW, Simmer JP, Hart TC et al. MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta. J Med Genet 2005;42:271-275. (Pubitemid 40380310)
66. Moffatt P, Smith CE, St-Arnaud R et al. Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia. J Cell Biochem 2008;103:941-956. (Pubitemid 351240629)