Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors

Development

Volumn 137, Issue 22, 2010, Pages 3743-3752

  Parsa, Sara ^a,b   Kuremoto, Koh Ichi ^c   Seidel, Kerstin ^d   Tabatabai, Reza ^a   MacKenzie, BreAnne ^e   Yamaza, Takayoshi ^f   Akiyama, Kentaro ^g   Branch, Jonathan ^a   Koh, Chester J ^a   Al Alam, Denise ^a   Klein, Ophir D ^d   Bellusci, Saverio ^a,b,e  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c OSAKA DENTAL UNIVERSITY   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^f KYUSHU UNIVERSITY   (Japan)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Ameloblasts; Enamel; FGF10; Fibroblast growth factor receptor 2b; Incisor regeneration; Mouse; Stem cells

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 2B; UNCLASSIFIED DRUG; UVOMORULIN; DOXYCYCLINE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 2;

AMELOBLAST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; ENAMEL; EPITHELIUM; INCISOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; TOOTH DEVELOPMENT; ADULT STEM CELL; ANIMAL; ANIMAL EMBRYO; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; MANDIBLE; MAXILLA; METABOLISM; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; TOOTH MALFORMATION;

ANIMALIA; RODENTIA;

ADULT STEM CELLS; AMELOBLASTS; AMELOGENESIS; ANIMALS; DOXYCYCLINE; EMBRYO, MAMMALIAN; FEMALE; FIBROBLAST GROWTH FACTORS; INCISOR; MANDIBLE; MAXILLA; MICE; PREGNANCY; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; TOOTH ABNORMALITIES;

EID: 78149272987     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.051672     Document Type: Article

References (22)

1. Belteki, G., Haigh, J., Kabacs, N., Haigh, K., Sison, K., Costantini, F., Whitsett, J., Quaggin, S. E. and Nagy, A. (2005). Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res. 33, e51.
2. Bitgood, M. J. and McMahon, A. P. (1995). Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172, 126-138.
3. de Maximy, A. A., Nakatake, Y., Moncada, S., Itoh, N., Thiery, J. P. and Bellusci, S. (1999). Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo. Mech. Dev. 81, 213-216.
4. De Moerlooze, L., Spencer-Dene, B., Revest, J., Hajihosseini, M., Rosewell, I. and Dickson, C. (2000). An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development 127, 483-492.
5. Gossen, M. and Bujard, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-5551.
6. Guven, Y., Rosti, R. O., Tuna, E. B., Kayserili, H. and Aktoren, O. (2008). Orodental findings of a family with lacrimo-auriculo-dento digital (LADD) syndrome. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 106, e33-44.
7. Harada, H., Kettunen, P., Jung, H. S., Mustonen, T., Wang, Y. A. and Thesleff, I. (1999). Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J. Cell Biol. 147, 105-120.
8. Harada, H., Toyono, T., Toyoshima, K., Yamasaki, M., Itoh, N., Kato, S., Sekine, K. and Ohuchi, H. (2002). FGF10 maintains stem cell compartment in developing mouse incisors. Development 129, 1533-1541.
9. Hokuto, I., Perl, A. K. and Whitsett, J. A. (2003). Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema. J. Biol. Chem. 278, 415-421.
10. Hollister, D. W., Klein, S. H., de Jager, H. J., Lachman, R. S. and Rimoin, D. L. (1974). Lacrimo-auriculo-dento-digital (LADD) syndrome. Birth Defects Orig. Artic. Ser. 10, 153-166.
11. Kerley, M. A. (1975). Pre-natal development of the mouse incisor. Proc. Natl. Acad. Sci. USA 55, 6-10.
12. Klein, O. D., Lyons, D. B., Balooch, G., Marshall, G. W., Basson, M. A., Peterka, M., Boran, T., Peterkova, R. and Martin, G. R. (2008). An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development 135, 377-385.
13. Lin, Y., Cheng, Y. S., Qin, C., Lin, C., D'Souza, R. and Wang, F. (2009). FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors. Dev. Dyn. 238, 324-330.
14. Mailleux, A. A., Kelly, R., Veltmaat, J. M., De Langhe, S. P., Zaffran, S., Thiery, J. P. and Bellusci, S. (2005). Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132, 2157-2166.
15. Mason, J. M., Morrison, D. J., Basson, M. A. and Licht, J. D. (2006). Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell. Biol. 16, 45-54.
16. O'Hagan, R. C. and Hassell, J. A. (1998). The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase. Oncogene 16, 301-310.
17. Parsa, S., Ramasamy, S. K., De Langhe, S., Gupte, V. V., Haigh, J. J., Medina, D. and Bellusci, S. (2008). Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling. Dev. Biol. 317, 121-131.
18. Roehl, H. and Nusslein-Volhard, C. (2001). Zebrafish pea3 and erm are general targets of FGF8 signaling. Curr. Biol. 11, 503-507.
19. Rohmann, E., Brunner, H. G., Kayserili, H., Uyguner, O., Nurnberg, G., Lew, E. D., Dobbie, A., Eswarakumar, V. P., Uzumcu, A., Ulubil-Emeroglu, M. et al. (2006). Mutations in different components of FGF signaling in LADD syndrome. Nat. Genet. 38, 414-417.
20. Schwenk, F., Baron, U. and Rajewsky, K. (1995). A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080-5081.
21. Wang, X. P., Suomalainen, M., Felszeghy, S., Zelarayan, L. C., Alonso, M. T., Plikus, M. V., Maas, R. L., Chuong, C. M., Schimmang, T. and Thesleff, I. (2007). An integrated gene regulatory network controls stem cell proliferation in teeth. PLoS Biol. 5, e159.
22. Yokohama-Tamaki, T., Ohshima, H., Fujiwara, N., Takada, Y., Ichimori, Y., Wakisaka, S., Ohuchi, H. and Harada, H. (2006). Cessation of Fgf10 signaling, resulting in a defective dental epithelial stem cell compartment, leads to the transition from crown to root formation. Development 133, 1359-1366.