Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme

Development

Volumn 128, Issue 11, 2001, Pages 2095-2106

  Colvin, J S ^a   white, A C ^a   Pratt, S J ^a   Ornitz, D M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

FGF; FGF receptor; FGF9; Knockout; Lung; Mesenchyme; Mouse

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 9;

AIRWAY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC REGULATION; HOMOZYGOSITY; LUNG ALVEOLUS CELL; LUNG DEVELOPMENT; LUNG HYPOPLASIA; MESENCHYME; MOUSE; NEWBORN DEATH; NONHUMAN; ORGAN SIZE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; FEMALE; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 9; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION; HEDGEHOG PROTEINS; LUNG; MALE; MESODERM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TRANS-ACTIVATORS;

EID: 0034956610     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
2. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
3. Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene
4. Male-to-female sex reversal in mice lacking fibroblast growth factor 9
5. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
6. Early fetal development of lung vasculature
7. Keratinocyte growth factor is required for hair development but not for wound healing
8. Anatomy of the lung
9. Embryology and development of the lung
10. Morphogenesis of the lung: Control of embryonic and fetal branching
11. Epithelial/mesenchymal interactions and branching morphogenesis of the lung
12. Characterization of recombinant human fibroblast growth factor (Fgf-10) reveals functional similarities with keratinocyte growth factor (Fgf-7)
13. Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
14. Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours
15. Fgf8 signalling from the AER is essential for normal limb development
16. The roles of FGFs in the early development of vertebrate limbs
17. Epithelial-mesenchymal interaction during lung development: The effect of mesenchymal mass
18. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
19. Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
20. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development
21. Receptor specificity of the fibroblast growth factor family
22. Fibroblast growth factors
23. Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)
24. FGF-10 is a chemotactic factor for distal epithelial buds during lung development
25. Sonic hedgehog regulates branching morphogenesis in the mammalian lung
26. Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse
27. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis
28. Immunohistochemical localization of mouse Clara cell 10-KD protein using antibodies raised against the recombinant protein
29. Expression and biological activity of mouse fibroblast growth factor-9 (FGF-9)
30. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
31. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development
32. Heterogeneity in microvascular density in lung tumours: Comparison with normal bronchus
33. Fgf10 is essential for limb and lung formation
34. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development Nat
35. The development of the lung in mammals: An analysis of concepts and findings
36. Lung growth and development
37. Mechanical forces alter growth factor release by pleural mesothelial cells
38. Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
39. Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis
40. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
41. Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice
42. Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy
43. Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B. C, and Clara cell secretory protein in developing mouse lung