Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia

Journal of Cellular Biochemistry

Volumn 103, Issue 3, 2008, Pages 941-956

  Moffatt, Pierre ^b,c   Smith, Charles E ^a   St Arnaud, René ^b,c   Nanci, Antonio ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Ameloblast; Basement membrane; Enamel organ; Gingiva; Junctional epithelium; Secreted protein; Tooth

Indexed keywords

AMYLOID; APIN; BACTERIAL PROTEIN; COMPLEMENTARY DNA; OXYGEN; UNCLASSIFIED DRUG;

AMELOBLAST; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; APIN GENE; ARTICLE; BASEMENT MEMBRANE; CELL LABELING; CELL LINE; CELL MATURATION; CONTROLLED STUDY; EPIDIDYMIS; EPITHELIUM; EPITHELIUM CELL; GENE; GENE EXPRESSION; GENE LOCATION; GENETIC TRANSFECTION; GENOME; GINGIVA; GLYCOSYLATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNODETECTION; INCISOR; MAMMAL; MOLECULAR CLONING; MOUSE; NONHUMAN; NORTHERN BLOTTING; NOSE; NUCLEOTIDE SEQUENCE; ODONTOGENIC TUMOR; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RAT; REAL TIME POLYMERASE CHAIN REACTION; SALIVARY GLAND; SWINE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; TOOTH FLORA;

AMELOBLASTS; AMINO ACID SEQUENCE; AMYLOID; ANIMALS; CELL LINE; CLONING, MOLECULAR; CONSERVED SEQUENCE; DENTAL ENAMEL PROTEINS; ENAMEL ORGAN; EPITHELIAL ATTACHMENT; EPITHELIUM; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GINGIVA; GLYCOSYLATION; HELA CELLS; HUMANS; INCISOR; MICE; ODONTOGENIC TUMORS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RATS; SEQUENCE ALIGNMENT; SWINE; TRANSCRIPTION, GENETIC;

AMPHIBIA; AVES; MAMMALIA; RATTUS; RODENTIA; SUIDAE;

EID: 39049165852     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21465     Document Type: Article

References (46)

1. Aung PP, Oue N, Mitani Y, Nakayama H, Yoshida K, Noguchi T, Bosserhoff AK, Yasui W. 2006. Systematic search for gastric cancer-specific genes based on SAGE data: Melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. Oncogene 25:2546-2557.
2. Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White SN, Zhou YL. 2006. 3. Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol 74:57-115.
3. Bonass WA, Kirkham J, Shore RC, Brookes SJ, Godfrey CL, Robinson C. 1998. Identification of rat enamel organ RNA transcripts using differential-display. Connect Tissue Res 38:249-256.
4. Caterina JJ, Skobe Z, Shi J, Ding Y, Simmer JP, Birkedal-Hansen H, Bartlett JD. 2002. Enamelysin (matrix metalloproteinase 20)-deficient mice display an amelogenesis imperfecta phenotype. J Biol Chem 277:49598-49604.
5. Chen LS, Couwenhoven RI, Hsu D, Luo W, Snead ML. 1992. Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ. Arch Oral Biol 37:771-778.
6. Church GM, Gilbert W. 1984. Genomic sequencing. Proc Natl Acad Sci USA 81:1991-1995.
7. Conchillo-Sole O, de Groot NS, Aviles FX, Vendrell J, Daura X, Ventura S. 2007. AGGRESCAN: A server for the prediction and evaluation of "hot spots" of aggregation in polypeptides. BMC Bioinformatics 8:65.
8. Dey R, Son HH, Cho MI. 2001. Isolation and partial sequencing of potentially odontoblast-specific/enriched rat cDNA clones obtained by suppression subtractive hybridization. Arch Oral Biol 46:249-260.
9. Fernandez-Escamilla AM, Rousseau F, Schymkowitz J, Serrano L. 2004. Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat Biotechnol 22:1302-1306.
10. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. 2005. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development 132:4375-4386.
11. Foster JS, Kestler DP, Murphy CL, Kennel SJ, Wall JS, Weiss DT, Solomon A. 2006. Amyloidogenic region of odontogenic ameloblast associated protein (ODAM). Amyloid 13(Suppl 1):28-29.
12. Fukae M, Tanabe T, Uchida T, Lee SK, Ryu OH, Murakami C, Wakida K, Simmer JP, Yamada Y, Bartlett JD. 1998. Enamelysin (matrix metalloproteinase-20): Localization in the developing tooth and effects of pH and calcium on amelogenin hydrolysis. J Dent Res 77:1580-1588.
13. Fukumoto S, Kiba T, Hall B, Iehara N, Nakamura T, Longenecker G, Krebsbach PH, Nanci A, Kulkarni AB, Yamada Y. 2004. Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. J Cell Biol 167:973-983.
14. Gibson CW, Yuan ZA, Hall B, Longenecker G, Chen E, Thyagarajan T, Sreenath T, Wright JT, Decker S, Piddington R, Harrison G, Kulkarni AB. 2001. Amelogenin-deficient mice display an amelogenesis imperfecta phenotype. J Biol Chem 276:31871-31875.
15. Hart PS, Hart TC, Michalec MD, Ryu OH, Simmons D, Hong S, Wright JT. 2004. Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta. J Med Genet 41:545-549.
16. Huq NL, Cross KJ, Ung M, Reynolds EC. 2005. A review of protein structure and gene organisation for proteins associated with mineralised tissue and calcium phosphate stabilisation encoded on human chromosome 4. Arch Oral Biol 50:599-609.
17. Iwasaki K, Bajenova E, Somogyi-Ganss E, Miller M, Nguyen V, Nourkeyhani H, Gao Y, Wendel M, Ganss B. 2005. Amelotin - A novel secreted, ameloblast-specific protein. J Dent Res 84:1127-1132.
18. Kawasaki K, Weiss KM. 2003. Mineralized tissue and vertebrate evolution: The secretory calcium-binding phosphoprotein gene cluster. Proc Natl Acad Sci USA 100:4060-4065.
19. Kawasaki K, Weiss KM. 2006. Evolutionary genetics of vertebrate tissue mineralization: The origin and evolution of the secretory calcium-binding phosphoprotein family. J Exp Zoolog B Mol Dev Evol 306:295-316.
20. Kinane DF, Shiba H, Hart TC. 2005. The genetic basis of periodontitis. Periodontal 2000 39:91-117.
21. Lal A, Lash AE, Altschul SF, Velculescu V, Zhang L, McLendon RE, Marra MA, Prange C, Morin PJ, Polyak K, Papadopoulos N, Vogelstein B, Kinzler KW, Strausberg RL, Riggins GJ. 1999. A public database for gene expression in human cancers. Cancer Res 59:5403-5407.
22. MacDougall M, Simmons D, Dodds A, Knight C, Luan X, Zeichner-David M, Zhang C, Ryu OH, Qian Q, Simmer JP, Hu CC. 1998. Cloning, characterization, and tissue expression pattern of mouse tuftelin cDNA. J Dent Res 77:1970-1978.
23. Masuya H, Shimizu K, Sezutsu H, Sakuraba Y, Nagano J, Shimizu A, Fujimoto N, Kawai A, Miura I, Kaneda H, Kobayashi K, Ishijima J, Maeda T, Gondo Y, Noda T, Wakana S, Shiroishi T. 2005. Enamelin (Enam) is essential for amelogenesis: ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI). Hum Mol Genet 14:575-583.
24. Miskin R, Masos T, Shoham Z, Williams-Simons L. 2006. Urokinase-type plasminogen activator mRNA is expressed in normal developing teeth and leads to abnormal incisor enamel in alphaMUPA transgenic mice. Transgenic Res 15:241-254.
25. Moffatt P, Salois P, St-Amant N, Gaumond MH, Lanctot C. 2004. Identification of a conserved cluster of skin-specific genes encoding secreted proteins. Gene 334:123-131.
26. Moffatt P, Smith CE, Sooknanan R, St-Arnaud R, Nanci A. 2006a. Identification of secreted and membrane proteins in the rat incisor enamel organ using a signal-trap screening approach. Eur J Oral Sci 114 (Suppl 1):139-146.
27. Moffatt P, Smith CE, St-Arnaud R, Simmons D, Wright JT, Nanci A. 2006b. Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium. Biochem J 399:37-46.
28. Moradian-Oldak J, Paine ML, Lei YP, Fincham AG, Snead ML. 2000. Self-assembly properties of recombinant engineered amelogenin proteins analyzed by dynamic light scattering and atomic force microscopy. J Struct Biol 131:27-37.
29. Nurminskaya M, Kaartinen MT. 2006. Transglutaminases in mineralized tissues. Front Biosci 11:1591-1606.
30. Orsini G, Lavoie P, Smith C, Nanci A. 2001. Immunochemical characterization of a chicken egg yolk antibody to secretory forms of rat incisor amelogenin. J Histochem Cytochem 49:285-292.
31. Ozyildirim AM, Wistow GJ, Gao J, Wang J, Dickinson DP, Frierson HF Jr, Laurie GW. 2005. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. Invest Ophthalmol Vis Sci 46:1572-1580.
32. Park JC, Park JT, Son HH, Kim HJ, Jeong MJ, Lee CS, Dey R, Cho ML. 2007. The amyloid protein APin is highly expressed during enamel mineralization and maturation in rat incisors. Eur J Oral Sci 115:153-160.
33. Philipsen HP, Reichart PA. 2000. Calcifying epithelial odontogenic tumour: Biological profile based on 181 cases from the literature. Oral Oncol 36:17-26.
34. Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ. 1995. Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem 270:9564-9570.
35. Presland RB, Dale BA. 2000. Epithelial structural proteins of the skin and oral cavity: Function in health and disease. Crit Rev Oral Biol Med 11:383-408.
36. Rios H, Koushik SV, Wang H, Wang J, Zhou HM, Lindsley A, Rogers R, Chen Z, Maeda M, Kruzynska-Frejtag A, Feng JQ, Conway SJ. 2005. Periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol 25:11131-11144.
37. Rosty C, Aubriot MH, Cappellen D, Bourdin J, Cartier I, Thiery JP, Sastre-Garau X, Radvanyi F. 2005. Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation. Mol Cancer 4:15.
38. Ryan MC, Lee K, Miyashita Y, Carter WG. 1999. Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. J Cell Biol 145:1309-1323.
39. Smith CE. 1998. Cellular and chemical events during enamel maturation. Crit Rev Oral Biol Med 9:128-161.
40. Smith CE, Nanci A, Moffatt P. 2006. Evidence by signal peptide trap technology for the expression of carbonic anhydrase 6 in rat incisor enamel organs. Eur J Oral Sci 114 (Suppl 1):147-153.
41. Solomon A, Murphy CL, Weaver K, Weiss DT, Hrncic R, Eulitz M, Donnell RL, Sletten K, Westermark G, Westermark P. 2003. Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein. J Lab Clin Med 142:348-355.
42. Sui W, Boyd C, Wright JT. 2003. Altered pH regulation during enamel development in the cystic fibrosis mouse incisor. J Dent Res 82:388-392.
43. The FANTOM Consortium. 2005. The transcriptional landscape of the mammalian genome. Science 309:1559-1563.
44. Thomas G, Moffatt P, Salois P, Gaumond MH, Gingras R, Godin E, Miao D, Goltzman D, Lanctot C. 2003. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. J Biol Chem 278:50563-50571.
45. Wilkinson M, Doskow J, Lindsey S. 1991. RNA blots: Staining procedures and optimization of conditions. Nucleic Acids Res 19:679.
46. Wright JT. 2006. The molecular etiologies and associated phenotypes of amelogenesis imperfecta. Am J Med Genet A 140A:2547-2555.