Design of new α-conotoxins: From computer modeling to synthesis of potent cholinergic compounds

Marine Drugs

Volumn 9, Issue 10, 2011, Pages 1698-1714

  Kasheverov, Igor E ^a   Zhmak, Maxim N ^a   Khruschov, Alexey Y ^a   Tsetlin, Victor I ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

Acetylcholine binding proteins; Computer modeling; Nicotinic acetylcholine receptors; Radioligand analysis; conotoxin analogs

Indexed keywords

ACETYLCHOLINE BINDING PROTEIN; ALPHA BUNGAROTOXIN; ALPHA CONOTOXIN GI; ALPHA CONOTOXIN IMI; ALPHA CONOTOXIN PNIA; BINDING PROTEIN; BUNGAROTOXIN RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT; CONOTOXIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; APLYSIA; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; COMPLEX FORMATION; COMPUTER MODEL; CONUS PENNACEUS; CONUS SNAIL; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; IC 50; IODINATION; LIGAND BINDING; LYMNAEA; LYMNAEA STAGNALIS; NONHUMAN;

APLYSIA CALIFORNICA; CONUS PENNACEUS; LYMNAEA STAGNALIS;

EID: 80054883697     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md9101698     Document Type: Article

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