Transmission and prevention of mood disorders among children of affectively ill parents: A review

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 50, Issue 11, 2011, Pages 1098-1109

  Beardslee, William R ^a,b   Gladstone, Tracy R G ^a,b,c   O'Connor, Erin E ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b JUDGE BAKER CHILDREN S CENTER   (United States)

^c WELLESLEY COLLEGE   (United States)

Author keywords

adolescents; children; depression; prevention

Indexed keywords

SEROTONIN;

ADAPTIVE BEHAVIOR; BIRTH WEIGHT; BRAIN ASYMMETRY; CHILD PARENT RELATION; COGNITION; COMMUNITY CARE; DEPRESSION; DISEASE COURSE; DISEASE SEVERITY; DISEASE TRANSMISSION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPIGENETICS; FAMILY LIFE; FAMILY THERAPY; GENDER; GENETIC ASSOCIATION; GENOTYPE ENVIRONMENT INTERACTION; HERITABILITY; HUMAN; LONGITUDINAL STUDY; MENTAL HEALTH; MENTAL PATIENT; MENTAL STRESS; PARENT; PARENTAL BEHAVIOR; PEER GROUP; PRIORITY JOURNAL; PROGENY; PSYCHOEDUCATION; REVIEW; REWARD; RISK ASSESSMENT; RISK FACTOR; SEROTONINERGIC TRANSMISSION; SLEEP DISORDER; TEMPERAMENT;

ADOLESCENT; AFFECT; CHILD; CHILD OF IMPAIRED PARENTS; HUMANS; MOOD DISORDERS;

EID: 80054875674     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1016/j.jaac.2011.07.020     Document Type: Review

References (100)

1. Kessler RC, Berglund P, Demler O et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289:3095- 3105.
2. World Health Organization. The Global Burden of Disease. Geneva: World Health Organization; 1996.
3. Greenberg PE, Kessler RC, Birnbaum HG et al. The economic burden of depression in the United States: how did it change between 1990 and 2000? J Clin Psychiatry. 2003;64:1465-1475. (Pubitemid 41270106)
4. Mueller TI, Leon AC, Keller MB et al. Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am J Psychiatry. 1999;156:1000-1006. (Pubitemid 29302790)
5. England MJ, Sim LJ. Depression in Parents, Parenting, and Children: Opportunities to Improve Identification, Treatment, and Prevention. Washington, DC: National Academies Press; 2009.
6. Brennan PA, Le Brocque R, Hammen C. Maternal depression, parent-child relationships, and resilient outcomes in adolescence. J Am Acad Child Adolesc Psychiatry. 2003;42:1469-1477. (Pubitemid 39585977)
7. Lewinsohn PM, Petit JW, Joiner TE Jr, Seeley JR. The symptomatic expression of major depressive disorder in adolescents and young adults. J Abnorm Psychol. 2003;112:244-252. (Pubitemid 36583179)
8. Weissman MM, Wolk S, Goldstein RB et al. Depressed adolescents grown up. JAMA. 1999;281:1707-1713. (Pubitemid 29226480)
9. Beardslee WR. Out of the Darkened Room: When a Parent is Depressed; Protecting the Children and Strengthening the Family. 1st ed. Boston: Little, Brown and Company; 2002.
10. Hammen C. Depression Runs in Families: The Social Context of Risk and Resilience in Children of Depressed Mothers. New York: Springer-Verlag; 1991.
11. Beardslee WR, Versage EM, Gladstone TRG. Children of affectively ill parents: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 1998;37:1134-1141.
12. Committee NRCaIoMP. Preventing Mental, Emotional, and Behavioral Disorders among Young People: Progress and Possibilities. Washington, DC: National Academies Press; 2009.
13. Warner V, Weissman MM, Mufson L, Wickramaratne PJ. Grandparents, parents, and grandchildren at high risk for depression: a three-generation study. J Am Acad Child Adolesc Psychiatry. 1999;38:289-296. (Pubitemid 29108741)
14. Weissman MM, Wickramaratne P, Nomura Y et al. Families at high and low risk for depression: a 3-generation study. Arch Gen Psychiatry. 2005;62:29-36. (Pubitemid 40096068)
15. Campbell SB, Morgan-Lopez AA, Cox MJ, McLoyd VC. A latent class analysis of maternal depressive symptoms over 12 years and offspring adjustment in adolescence. J Abnorm Psychol. 2009;118:479-493.
16. Bruder-Costello B, Warner V, Talati A, Nomura Y, Bruder G, Weissman M. Temperament among offspring at high and low risk for depression. Psychiatry Res. 2007;153:145-151. (Pubitemid 47539595)
17. Weissman MM, Wickramaratne P, Nomura Y, Warner V, Pilowsky D, Verdeli H. Offspring of depressed parents: 20 years later. Am J Psychiatry. 2006;163:1001-1008. (Pubitemid 44464486)
18. Espejo EP, Hammen CL, Connolly NP, Brennan PA, Najman JM, Bor W. Stress sensitization and adolescent depressive severity as a function of childhood adversity: a link to anxiety disorders. J Abnorm Child Psychol. 2007;35:287-299. (Pubitemid 46569941)
19. Pilowsky DJ, Wickramaratne PJ, Rush AJ et al. Children of currently depressed mothers: a STAR*D ancillary study. J Clin Psychiatry. 2006;67:126-136. (Pubitemid 43213293)
20. Goodman SH, Gotlib IH. Transmission of risk to children of depressed parents: Integration and conclusions. In: Goodman SH, Gotlib IH, eds. Children of Depressed Parents: Mechanisms of Risk and Implications for Treatment. Washington, DC: American Psychological Association; 2002:307-326.
21. Forbes EE, Shaw DS, Silk JS et al. Children's affect expression and frontal EEG asymmetry: transactional associations with mothers' depressive symptoms. J Abnorm Child Psychol. 2008; 36:207-221.
22. Gross HE, Shaw DS, Moilanen KL. Reciprocal associations between boys' externalizing problems and mothers' depressive symptoms. J Abnorm Child Psychol. 2008;36:693-709.
23. Beardslee WR. Prevention and the clinical encounter. Am J Orthopsychiatry. 1998;68:521-533. (Pubitemid 28520733)
24. Wilson S, Durbin CE. Effects of paternal depression on fathers'parenting behaviors: A meta-analytic review. Clin Psychol Rev. 2010;30:167-180.
25. Kane P, Garber J. Parental depression and child externalizing and internalizing symptoms: unique effects of fathers' symptoms and perceived conflict as a mediator. J Child Fam Stud. 2009;18:465-472.
26. Landman-Peeters KMC, Ormel J, Van Sonderen ELP, Den Boer JA, Minderaa RB, Hartman CA. Risk of emotional disorder in offspring of depressed parents: Gender differences in the effect of a second emotionally affected parent. Depress Anxiety. 2008; 25:653-660.
27. Reeb BT, Conger KJ, Wu EY. Paternal depressive symptoms and adolescent functioning: the moderating effect of gender and father hostility. Fathering. 2010;8:131-142.
28. Brennan PA, Hammen C, Andersen MJ, Bor W, Najman JM, Williams GM. Chronicity, severity, and timing of maternal depressive symptoms: relationships with child outcomes at age 5. Dev Psychol. 2000;36:759-766.
29. Chazan-Cohen R, Ayoub C, Pan BA et al. It takes time: Impacts on Early Head Start that lead to reductions in maternal depression two years later. Infant Ment Health J. 2007;28:151-170. (Pubitemid 46993505)
30. Sheeber L, Davis B, Hops H. Gender-specific vulnerability to depression in children of depressed mothers. In: Goodman SH, Gotlib IH, eds. Children of Depressed Parents: Mechanisms of Risk and Implications for Treatment. Washington, DC: American Psychological Association; 2002:253-274.
31. Essex MJ, Klein MH, Cho E, Kraemer HC. Exposure to maternal depression and marital conflict: Gender differences in children's later mental health symptoms. J Am Acad Child Adolesc Psychiatry. 2003;42:728-737. (Pubitemid 39625059)
32. Foster CE, Webster MC, Weissman MM et al. Course and severity of maternal depression: associations with family functioning and child adjustment. J Youth Adolesc. 2008;37:906-916.
33. Bagot RC, Meaney MJ. Epigenetics and the biological basis of gene x environment interactions. J Am Acad Child Adolesc Psychiatry. 2010;49:752-771.
34. Rice F, Harold G, Thaper A. The genetic aetiology of childhood depression: a review. J Child Psychol Psychiatry. 2002;43:65-79. (Pubitemid 36939201)
35. Kendler KS, Baker JH. Genetic influences on measures of the environment: a systematic review. Psychol Med. 2007;37:615- 626.
36. Hochberg Z, Feil R, Constancia M et al. Child health, developmental plasticity, and epigenetic programming. Endocr Rev. 2011;32:159-224.
37. Hammen C, Brennan PA, Keenan-Miller D, Hazel NA, Najman JM. Chronic and acute stress, gender, and serotonin transporter gene environment interactions predicting depression symptoms in youth. J Child Psychol Psychiatry. 2010;51:180-187.
38. Schumacher J, Jamra RA, Becker T et al. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry. 2005;58:307-314. (Pubitemid 41133624)
39. López-León S, Janssens ACJW, Ladd AMG-Z et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry. 2008;13:772-785. (Pubitemid 352032108)
40. Caspi A, Sugden K, Moffitt TE et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386-389. (Pubitemid 36877077)
41. Gibb BE, Uhrlass DJ, Grassia M, Benas JS, McGeary J. Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: an integrated model for the intergenerational transmission of depression. J Abnorm Psychol. 2009;118:734-745.
42. Risch N, Herrell R, Lehner T et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. 2009;301:2462-2471.
43. Munafò MR, Durrant C, Lewis G, Flint J. Gene x environment interactions at the serotonin transporter locus. Biol Psychiatry. 2009;65:211-219.
44. Hoffman EJ, State MW. Progress in cytogenetics: implications for child psychopathology. J Am Acad Child Adolesc Psychiatry. 2010;49:736-751.
45. Pine DS, Ernst M, Leibenluft E. Imaging-genetics applications in child psychiatry. J Am Acad Child Adolesc Psychiatry. 2010;49: 772-782.
46. Bruder GE, Tenke CE, Warner V, Weissman MM. Grandchildren at high and low risk for depression differ in EEG measures of regional brain asymmetry. Biol Psychiatry. 2007;62:1317-1323. (Pubitemid 350060884)
47. Peterson BS, Warner V, Bansal R et al. Cortical thinning in persons at increased familial risk for major depression. Proc Natl Acad Sci U S A. 2009;106:6273-6278.
48. Rao U, Chen L-A, Bidesi AS, Shad MU, Thomas MA, Hammen CL. Hippocampal changes associated with early-life adversity and vulnerability to depression. Biol Psychiatry. 2010;67:357-364.
49. Gotlib IH, Hamilton JP, Cooney RE, Singh MK, Henry ML, Joormann J. Neural processing of reward and loss in girls at risk for major depression. Arch Gen Psychiatry. 2010;67:380-387.
50. Szklo-Coxe M, Young T, Peppard PE, Finn LA, Benca RM. Prospective associations of insomnia markers and symptoms with depression. Am J Epidemiol. 2010;171:709-720.
51. Ong SH, Wickramaratne P, Tang M, Weissman MM. Early childhood sleep and eating problems as predictors of adolescent and adult mood and anxiety disorders. J Affect Disord. 2006;96: 1-8. (Pubitemid 44548055)
52. Nomura Y, Wickramaratne PJ, Pilowsky DJ et al. Low birth weight and risk of affective disorders and selected medical illness in offspring at high and low risk for depression. Compr Psychiatry. 2007;48:470-478. (Pubitemid 47247433)
53. Ge X, Conger RD, Elder GH Jr. Pubertal transition, stressful life events, and the emergence of gender differences in adolescent depressive symptoms. Dev Psychol. 2001;37:404-417.
54. Ellis BJ, Garber J. Psychosocial antecedents of variation in girls'pubertal timing: maternal depression, stepfather presence, and marital and family stress. Child Dev. 2000;71:485-501.
55. Lovejoy MC, Graczyk PA, O'Hare E, Neuman G. Maternal depression and parenting behavior: a meta-analytic review. Clin Psychol Rev. 2000;20:561-592. (Pubitemid 30326803)
56. Rutter M. Resilience in the face of adversity: protective factors and resistance to psychiatric disorder. Br J Psychiatry. 1985;147: 598-611. (Pubitemid 16175701)
57. Milan S, Snow S, Belay S. Depressive symptoms in mothers and children: preschool attachment as a moderator of risk. Dev Psychol. 2009;45:1019-1033.
58. Abela JRZ, Hankin BL, Haigh EAP, Adams P, Vinokuroff T, Trayhern L. Interpersonal vulnerability to depression in highrisk children: the role of insecure attachment and reassurance seeking. J Clin Child Adolesc Psychol. 2005;34:182-192. (Pubitemid 40272946)
59. Middleton M, Scott SL, Renk K. Parental depression, parenting behaviours, and behaviour problems in young children. Infant Child Dev. 2009;18:323-336.
60. Feng X, Shaw DS, Skuban EM, Lane T. Emotional exchange in mother-child dyads: Stability, mutual influence, and associations with maternal depression and child problem behavior. J Fam Psychol. 2007;21:714-725.
61. Dietz LJ, Birmaher B, Williamson DE et al. Mother-child interactions in depressed children and children at high risk and low risk for future depression. J Am Acad Child Adolesc Psychiatry. 2008;47:574-582. (Pubitemid 351591607)
62. Frye AA, Garber J. The relations among maternal depression, maternal criticism, and adolescents' externalizing and internalizing symptoms. J Abnorm Child Psychol. 2005;33:1-11. (Pubitemid 40558439)
63. Schwartz CE, Dorer DJ, Beardslee WR, Lavori PW. Maternal expressed emotion and parental affective disorder: risk for childhood depressive disorder, substance abuse, or conduct disorder. J Psychiatr Res. 1990;24:231-250. (Pubitemid 20347108)
64. Tompson MC, Pierre CB, Boger KD, McKowen JW, Chan PT, Freed RD. Maternal depression, maternal expressed emotion, and youth psychopathology. J Abnorm Child Psychol. 2010;38: 105-117.
65. Avenevoli S, Merikangas KR. Implications of high-risk family studies for prevention of depression. Am J Prev Med. 2006; 31(suppl 1):S126-S135.
66. Pettit JW, Olino TM, Roberts RE, Seeley JR, Lewinsohn PM. Intergenerational transmission of internalizing problems: effects of parental and grandparental major depressive disorder on child behavior. J Clin Child Adolesc Psychol. 2008;37:640-650.
67. Fear JM, Champion JE, Reeslund KL et al. Parental depression and interparental conflict: children and adolescents' self-blame and coping responses. J Fam Psychol. 2009;23:762-766.
68. Hammen C, Brennan PA, Shih JH. Family discord and stress predictors of depression and other disorders in adolescent children of depressed and nondepressed women. J Am Acad Child Adolesc Psychiatry. 2004;43:994-1002. (Pubitemid 38971721)
69. Briggs-Gowan MJ, Carter AS, Clark R, Augustyn M, McCarthy KJ, Ford JD. Exposure to potentially traumatic events in early childhood: differential links to emergent psychopathology. J Child Psychol Psychiatry. 2010;51:1132-1140.
70. Morris MC, Ciesla JA, Garber J. A prospective study of stress autonomy versus stress sensitization in adolescents at varied risk for depression. J Abnorm Psychol. 2010;119:341-354.
71. Hammen C, Henry R, Daley SE. Depression and sensitization to stressors among young women as a function of childhood adversity. J Consult Clin Psychol. 2000;68:782-787.
72. Compas BE, Orosan PG, Grant KE. Adolescent stress and coping: Implications for psychopathology during adolescence. J Adolesc. 1993;16:331-349. (Pubitemid 23330070)
73. Pine DS, Cohen E, Cohen P, Brook J. Adolescent depressive symptoms as predictors of adult depression: moodiness or mood disorder? Am J Psychiatry. 1999;156:133-135. (Pubitemid 29034892)
74. Brent DA, Birmaher B, Kolko D, Baugher M, Bridge J. Subsyndromal depression in adolescents after a brief psychotherapy trial: course and outcome. J Affect Disord. 2001;63(1-3):51-58. (Pubitemid 32200498)
75. Garber J, Flynn C. Predictors of depressive cognitions in young adolescents. Cogn Ther Res. 2001;25:353-376. (Pubitemid 39550072)
76. Abela JRZ, Skitch SA, Adams P, Hankin BL. The timing of parent and child depression: a hopelessness theory perspective. J Clin Child Adolesc Psychol. 2006;35:253-263. (Pubitemid 43723181)
77. Rudolph KD, Klein DN. Exploring depressive personality traits in youth: origins, correlates, and developmental consequences. Dev Psychopathol. 2009;21:1155-1180.
78. Hammen C, Brennan PA, Keenan-Miller D. Patterns of adolescent depression to age 20: the role of maternal depression and youth interpersonal dysfunction. J Abnorm Child Psychol. 2008; 36:1189-1198.
79. Horowitz JL, Garber J. Relation of intelligence and religiosity to depressive disorders in offspring of depressed and nondepressed mothers. J Am Acad Child Adolesc Psychiatry. 2003;42: 578-586. (Pubitemid 39625069)
80. Gladstone TRG, Beardslee WR. The prevention of depression in children and adolescents: a review. Can J Psychiatry. 2009;54: 212-221.
81. Gladstone TRG, Beardslee WR, O'Connor EE. The prevention of adolescent depression. Psychiatr Clin North Am. 2011;34:35-52.
82. Muñoz RF, Cuijpers P, Smit F, Barrera AZ, Leykin Y. Prevention of major depression. Annu Rev Clin Psychol. 2010;6:181-212.
83. Clarke GN, Hornbrook M, Lynch F et al. A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents. Arch Gen Psychiatry. 2001;58:1127-1134. (Pubitemid 33121504)
84. Garber J, Clarke GN, Brent D. Preventing depression in at-risk adolescents: design and sample characteristics. Paper presented at: American Academy of Child and Adolescent Psychiatry; Boston, MA; October 2007.
85. Clarke GN, Hawkins W, Murphy M, Sheeber LB. Targeted prevention of unipolar depressive disorder in an at-risk sample of high school adolescents: a randomized trial of group cognitive intervention. J Am Acad Child Adolesc Psychiatry. 1995;34:312- 321.
86. Compas BE, Forehand R, Keller G et al. Randomized controlled trial of a family cognitive-behavioral preventive intervention for children of depressed parents. J Consult Clin Psychol. 2009;77: 1007-1020.
87. Compas B, Forehand R, Thigpen JC et al. Family group cognitive-behavioral preventive intervention for families of depressed parents: 18- and 24-month outcomes [published online ahead of print June 27, 2011]. J Consult Clin Psychol. doi:10.1037/ a0024254.
88. Beardslee WR, Gladstone TRG, Wright EJ. A family-based approach to the prevention of depressive symptoms in children at risk: evidence of parental and child change. Pediatrics. 2003; 112:E99-111.
89. Beardslee WR, Wright EJ, Gladstone TRG, Forbes P. Long-term effects from a randomized trial of two public health preventive interventions for parental depression. J Fam Psychol. 2007;21: 703-713.
90. D'Angelo EJ, Llerena-Quinn R, Shapiro R et al. Adaptation of the Preventive Intervention Program for Depression for use with predominantly low-income Latino families. Fam Process. 2009; 48:269-291.
91. Solantaus T, Toikka S, Alasuutari M, Beardslee WR, Paavonen EJ. Safety, feasibility and family experiences of preventive interventions for children and families with parental depression. Int J Ment Health Promot. 2009;11:15-24.
92. Beardslee W, Paez-Soto A, Herrera-Amighetti L et al. Adaptation of a preventive intervention approach to strengthen families facing adversities, especially depression. Int J Ment Health Promot. 2011;13:5-13.
93. Chu AT, Lieberman AF. Clinical implications of traumatic stress from birth to age five. Annu Rev Clin Psychol. 2010;6:469-494.
94. Ammerman RT, Putnam FW, Stevens J et al. An open trial of in-home CBT for depressed mothers in home visitation [published online ahead of print October 9, 2010]. Matern Child Health J. doi:10.1007/s10995-010-0691-7.
95. Beardslee WR, Ayoub C, Avery MW, Watts CL, O'Carroll KL. Family connections: an approach for strengthening early care systems in facing depression and adversity. Am J Orthopsychiatry. 2010;80:482-495.
96. Gunlicks ML, Weissman MM. Change in child psychopathology with improvement in parental depression: A asystematic review. J Am Acad Child Adolesc Psychiatry. 2008;47:379-389. (Pubitemid 351450736)
97. Riley AW, Valdez CR, Barrueco S et al. Development of a family-based program to reduce risk and promote resilience among families affected by maternal depression: theoretical basis and program description. Clin Child Fam Psychol Rev. 2008;11:12-29.
98. Lau JYF, Eley TC. The genetics of adolescent depression. In: Nolen-Hoeksema S, Hilt LM, eds. Handbook of Depression in Adolescents. New York: Routledge/Taylor and Francis Group; 2009:259-278.
99. Voorhees BWV, Mahoney N, Mazo R et al. Internet-based depression prevention over the life course: a call for behavioral vaccines. Psychiatr Clin North Am. 2011;34:167-183.
100. Horowitz JL, Garber J. The prevention of depressive symptoms in children and adolescents: a meta-analytic review. J Consult Clin Psychol. 2006;74:401-415. (Pubitemid 44128221)