First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4217-4222

  Palmioli, Alessandro ^a   Sacco, Elena ^a   Abraham, Sherwin ^c   Thomas, Celestine J ^b   Domizio, Alessandro Di ^a   Gioia, Luca De ^a   Gaponenko, Vadim ^c   Vanoni, Marco ^a   Peri, Francesco ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF MONTANA   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Anticancer agents; Molecular modeling; NMR; Ras protein; Sugars; Synthesis

Indexed keywords

GUANINE NUCLEOTIDE; NITROGEN 15; PROTEIN INHIBITOR; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HETERONUCLEAR SINGLE QUANTUM COHERENCE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN INTERACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GLUCOSIDES; GUANINE; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NIH 3T3 CELLS; PROTEIN BINDING; RAS PROTEINS; SULFONAMIDES;

EID: 67650168962     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.107     Document Type: Article

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