O-demethylation of tramadol in the first months of life

European Journal of Clinical Pharmacology

Volumn 61, Issue 11, 2005, Pages 837-842

  Allegaert, Karel ^a,b   Van Den Anker, J N ^b,c,d   Verbesselt, R ^a   De Hoon, J ^a   Vanhole, C ^a   Tibboel, D ^b   Devlieger, H ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^d GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

CYP2D6 activity; Maturation; Neonate; Tramadol

Indexed keywords

DRUG METABOLITE; O DEMETHYL TRAMADOL; TRAMADOL; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION ANALYSIS; DEMETHYLATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ENZYME ACTIVITY; GENETIC POLYMORPHISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFANT; MULTIPLE REGRESSION; NEWBORN; PERINATAL PERIOD; PLASMA; PRIORITY JOURNAL; URINE;

AGING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; HALF-LIFE; HUMANS; INFANT; INFANT, NEWBORN; LINEAR MODELS; NARCOTICS; TRAMADOL;

EID: 28344434930     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-005-0045-3     Document Type: Article

References (15)

1. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kaufman RE (2003) Developmental pharmacology - drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157-1167
2. Hines RN, McCarver DG (2002) The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes. J Pharmacol Exp Ther 300:355-360
3. Ladona MG, Lindstrom B, Thyr C, Dun-Ren P, Rane A (1991) Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man. Br J Clin Pharmacol 32:295-302
4. Treluyer JM, Jacqz-Aigrain E, Alvarez F, Cresteil T (1991) Expression of CYP2D6 in developing human liver. Eur J Biochem 202:583-588
5. Jacqz-Aigrain E, Cresteil T (1992) Cytochrome P450-dependent metabolism of dextromethorphan: fetal and adult studies. Dev Pharmacol Ther 18:161-168
6. Grond S, Sablotzki A (2004) Clinical pharmacology of tramadol. Clin Pharmacokinet 43:879-923
7. Allegaert K, Anderson B, Verbesselt R, Debeer A, de Hoon J, Devlieger H, JN Van den Anker, Tibboel D (2005) Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P4502D6 activity. Br J Anaesth 95:231-239
8. Pedersen RS, Damkier P, Brosen K (2005) Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study. Clin Pharmacol Ther 77:458-467
9. Paar WD, Poche S, Gerloff J, Dengler HJ (1997) Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol. Eur J Clin Pharmacol 53:235-239
10. Campanero MA, Calahorra B, Garcia-Quetglas E, Escolar M, Honorato J (1998) High performance liquid chromatographic assay for simultaneous determination of tramadol and its active metabolite in human plasma. Application to pharmacokinetic studies. Chromatographia 48(7/8):555
11. Nobilis M, Kopecky J, Kvetina J, Chladek J, Svoboda Z, Vorisek V, Perlik F, Pour M, Kunes J (2002) High performance liquid chromatographic determination of tramadol and its O-demethylated metabolite in blood plasma. Application to a bioequivalence study in humans. J Chromatogr A 949:11-22
12. Overbeck P, Blaschke G (1999) Direct determination of tramadol glucuronides in human urine by high performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl 732:185-192
13. Park J, Kim K, Park P, Lee D, Kim H, Park C, Shin J (2005) Effect of age on the activity of cytochrome P450 2D6 using dextromethorphan phenotyping in humans. Clin Pharmacol Ther 77:P24
14. Murthy BV, Pandya KS, Booker PD, Murray A, Lintz W, Terlinden R (2000) Pharmacokinetics of tramadol in children after i.v. or caudal epidural administration. Br J Anaesth 84:346-349
15. Stamer UM, Lehnen K, Hothker F, Bayerer B, Wolf S, Hoeft A, Stuber F (2003) Impact of CYP2D6 genotype on postoperative tramadol analgesia. Pain 105:231-238