Tramadol disposition in the very young: An attempt to assess in vivo cytochrome P-450 2D6 activity

British Journal of Anaesthesia

Volumn 95, Issue 2 PAPER, 2005, Pages 231-239

  Allegaert, Karel ^a,b   Anderson, B J ^c   Verbesselt, R ^a   Debeer, A ^a   de Hoon, J ^a   Devlieger, H ^a   Van Den Anker, J N ^b,d,e   Tibboel, D ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^e GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Analgesics opioid, tramadol; Drug, tramadol, age factors; Pharmacokinetics, tramadol, maturation, CYP2D6 activity

Indexed keywords

CYTOCHROME P450 2D6; DRUG METABOLITE; O NORTRAMADOL; TRAMADOL; UNCLASSIFIED DRUG; NARCOTIC ANALGESIC AGENT;

ARTICLE; BOLUS INJECTION; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG INFUSION; DRUG METABOLISM; ENZYME ACTIVITY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; IN VIVO STUDY; INFANT; LINEAR SYSTEM; NEWBORN; NEWBORN INTENSIVE CARE; NONLINEAR SYSTEM; PEDIATRIC ANESTHESIA; PHARMACODYNAMICS; PHARMACOGENETICS; PRIORITY JOURNAL; STANDARDIZATION; ADULT; CLINICAL TRIAL; METABOLISM; MIDDLE AGED; STATISTICAL MODEL; TIME;

ADULT; ANALGESICS, OPIOID; CYTOCHROME P-450 CYP2D6; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INFANT; INFANT, NEWBORN; LINEAR MODELS; MIDDLE AGED; TIME FACTORS; TRAMADOL;

EID: 23844533652     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aei170     Document Type: Article

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