The role of light in the developement of RPE degeneration in AMD and potential cytoprotection of minocycline;Altersbedingte Makuladegeneration: die Rolle von Licht bei der Entstehung degenerativer Veränderungen im menschlichen RPE und möglicher Zell-Schutz durch Minocyclin

Klinische Monatsblatter fur Augenheilkunde

Volumn 228, Issue 10, 2011, Pages 892-899

  Kernt, M ^a   Thiele, S ^a   Hirneiss, C ^a   Neubauer, A S ^a   Lackerbauer, C A ^a   Ulbig, M W ^a   Kampik, A ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

AMD; apoptosis; minocycline; oxidative stress; Pharmacology

Indexed keywords

MESSENGER RNA; MINOCYCLINE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL DEGENERATION; CELL PROTECTION; CELL VIABILITY; HUMAN; HUMAN CELL; INCUBATION TIME; LIGHT EXPOSURE; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RETINA MACULA AGE RELATED DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTI-BACTERIAL AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL DEATH; CELL PROLIFERATION; CELLS, CULTURED; CYTOPROTECTION; HUMANS; LIGHT; MACULAR DEGENERATION; MINOCYCLINE; PIGMENT EPITHELIUM OF EYE; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 80054764355     PISSN: 00232165     EISSN: 14393999     Source Type: Journal    
DOI: 10.1055/s-0029-1245892     Document Type: Article

References (52)

1. Hawkins B S., Bird A, Klein R et al. Epidemiology of age-related macular degeneration. Mol Vis 1999 5 26
2. Klein R, Klein B E., Jensen S C. et al. Age-related maculopathy in a multiracial United States population: the National Health and Nutrition Examination Survey III. Ophthalmology 1999 106 1056-1065 (Pubitemid 30191505)
3. Rosenfeld P J., Brown D M., Heier J S. et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006 355 1419-1431 (Pubitemid 44511557)
4. Rosenfeld P J., Fung A E., Puliafito C A. Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for macular edema from central retinal vein occlusion. Ophthalmic Surg Lasers Imaging 2005 36 336-339 (Pubitemid 41073113)
5. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol 2001 119 1439-1452
6. Klein R, Peto T, Bird A et al. The epidemiology of age-related macular degeneration. Am J Ophthalmol 2004 137 486-495 (Pubitemid 38328641)
7. Schmidt S, Hauser M A., Scott W K. et al. Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. Am J Hum Genet 2006 78 852-864
8. Cruickshanks K J., Klein R, Klein B E. Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol 1993 111 514-518 (Pubitemid 23116899)
9. Klein R, Klein B E., Linton K L. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 1992 99 933-943
10. Beatty S, Murray I J., Henson D B. et al. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest Ophthalmol Vis Sci 2001 42 439-446 (Pubitemid 32121477)
11. Cai J, Nelson K C., Wu M et al. Oxidative damage and protection of the RPE. Prog Retin Eye Res 2000 19 205-221
12. Winkler B S., Boulton M E., Gottsch J D. et al. Oxidative damage and age-related macular degeneration. Mol Vis 1999 5 32
13. Chen M, Ona V O., Li M et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 2000 6 797-801 (Pubitemid 30469429)
14. Yrjanheikki J, Keinanen R, Pellikka M et al. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A 1998 95 15769-15774 (Pubitemid 29018775)
15. Zhu S, Stavrovskaya I G., Drozda M et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 2002 417 74-78 (Pubitemid 34498818)
16. Sanchez Mejia R O., Ona V O., Li M et al. Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 2001 48 1393-1399; discussion 1399 1401
17. Popovic N, Schubart A, Goetz B D. et al. Inhibition of autoimmune encephalomyelitis by a tetracycline. Ann Neurol 2002 51 215-223 (Pubitemid 34111444)
18. Du Y, Ma Z, Lin S et al. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinsons disease. Proc Natl Acad Sci U S A 2001 98 14669-14674 (Pubitemid 33121449)
19. Kernt M, Hirneiss C, Neubauer A S. et al. Protektive Wirkung Blaulicht absorbierender IOLs auf das menschliche retinale Pigmentepithel. Ophthalmologe 2010 107 (2) 150-157
20. Holz F G., Pauleikhoff D, Klein R et al. Pathogenesis of lesions in late age-related macular disease. Am J Ophthalmol 2004 137 504-510 (Pubitemid 38328643)
21. Sparrow J R., Cai B. Blue light-induced apoptosis of A 2E-containing RPE: involvement of caspase-3 and protection by Bcl-2. Invest Ophthalmol Vis Sci 2001 42 1356-1362 (Pubitemid 32381981)
22. Barishak Y R. In vitro behaviour of the pigmented cells of the retina and uvea of the adult human eye. Acta Ophthalmol 1960 38 339-346
23. Flood M T., Gouras P, Kjeldbye H. Growth characteristics and ultrastructure of human retinal pigment epithelium in vitro. Invest Ophthalmol Vis Sci 1980 19 1309-1320 (Pubitemid 11078429)
24. Nilsson S E., Sundelin S P., Wihlmark U et al. Aging of cultured retinal pigment epithelial cells: oxidative reactions, lipofuscin formation and blue light damage. Doc Ophthalmol 2003 106 13-16 (Pubitemid 36355966)
25. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983 65 55-63 (Pubitemid 14203433)
26. Kernt M, Neubauer A S., Liegl R et al. Cytoprotective effects of a blue light-filtering intraocular lens on human retinal pigment epithelium by reducing phototoxic effects on vascular endothelial growth factor-alpha, Bax, and Bcl-2 expression. J Cataract Refract Surg 2009 35 354-362
27. Nishikawa T, Edelstein D, Du X L. et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000 404 787-790 (Pubitemid 30212409)
28. Kernt M, Hirneiss C, Neubauer A S. et al. Minocycline is cytoprotective in human corneal endothelial cells and induces anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and X-linked inhibitor of apoptosis (XIAP). Br J Ophthalmol 2010 94 940-946
29. Kernt M, Hirneiss C, Wolf A et al. Indocyanine green increases light-induced oxidative stress, senescence, and matrix metalloproteinases 1 and 3 in human RPE cells. Acta Ophthalmol 2010 Jul. 29. Epub ahead of print
30. Resnikoff S, Pascolini D, Etyaale D et al. Global data on visual impairment in the year 2002. Bull World Health Organ 2004 82 844-851 (Pubitemid 39573742)
31. Ferris 3rd F L., Fine S L., Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol 1984 102 1640-1642 (Pubitemid 15204559)
32. Congdon N, OColmain B, Klaver C C. et al. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 2004 122 477-485 (Pubitemid 38456282)
33. Knudtson M D., Klein R, Klein B E. et al. Location of lesions associated with age-related maculopathy over a 10-year period: the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 2004 45 2135-2142 (Pubitemid 38902581)
34. Algvere P V., Marshall J, Seregard S. Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand 2006 84 4-15 (Pubitemid 43337467)
35. Chow C K., Chen L H., Thacker R R. et al. Dietary vitamin E and pulmonary biochemical responses of rats to cigarette smoking. Environ Res 1984 34 8-17 (Pubitemid 14056977)
36. Chow C K., Thacker R R., Changchit C et al. Lower levels of vitamin C and carotenes in plasma of cigarette smokers. J Am Coll Nutr 1986 5 305-312
37. Church D F., Pryor W A. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985 64 111-126 (Pubitemid 16135783)
38. Dorey C K., Delori F C., Akeo K. Growth of cultured RPE and endothelial cells is inhibited by blue light but not green or red light. Curr Eye Res 1990 9 549-559 (Pubitemid 20316715)
39. Demontis G C., Longoni B, Marchiafava P L. Molecular steps involved in light-induced oxidative damage to retinal rods. Invest Ophthalmol Vis Sci 2002 43 2421-2427 (Pubitemid 34700677)
40. Grimm C, Wenzel A, Williams T et al. Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching. Invest Ophthalmol Vis Sci 2001 42 497-505 (Pubitemid 32121486)
41. Hafezi F, Marti A, Munz K et al. Light-induced apoptosis: differential timing in the retina and pigment epithelium. Exp Eye Res 1997 64 963-970 (Pubitemid 27314771)
42. Jin G F., Hurst J S., Godley B F. Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells. Curr Eye Res 2001 22 165-173 (Pubitemid 32881422)
43. Katz M L. Potential role of retinal pigment epithelial lipofuscin accumulation in age-related macular degeneration. Arch Gerontol Geriatr 2002 34 359-370 (Pubitemid 34224173)
44. Levine A J. p53, the cellular gatekeeper for growth and division. Cell 1997 88 323-331 (Pubitemid 27131374)
45. Miyashita T, Reed J C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995 80 293-299
46. Hockenbery D M. The bcl-2 oncogene and apoptosis. Semin Immunol 1992 4 413-420
47. Klein N C., Cunha B A. Tetracyclines. Med Clin North Am 1995 79 789-801
48. Ryan M E., Greenwald R A., Golub L M. Potential of tetracyclines to modify cartilage breakdown in osteoarthritis. Curr Opin Rheumatol 1996 8 238-247 (Pubitemid 26192788)
49. Wirostko E, Wirostko W J., Wirostko B M. Age-related macular degeneration is an inflammatory disease possibly treatable with minocycline. Acta Ophthalmol Scand 2004 82 243-244 (Pubitemid 38515391)
50. Kernt M, Neubauer A S., Eibl K H. et al. Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2. Clin Ophthalmol 2010 4 591-604
51. Cao Y, Wei H, Pfaffl M et al. Apoptosis of human trabecular meshwork cells induced by transforming growth factor-beta2 in vitro. J Huazhong Univ Sci Technolog Med Sci 2004 24 87-89, 94
52. Kumar D M., Agarwal N. Oxidative stress in glaucoma: a burden of evidence. J Glaucoma 2007 16 334-343 (Pubitemid 46626062)