Fine-mapping alleles for body weight in LG/J × SM/J F 2 and F 34 advanced intercross lines

Mammalian Genome

Volumn 22, Issue 9-10, 2011, Pages 563-571

  Parker, Clarissa C ^a   Cheng, Riyan ^a   Sokoloff, Greta ^a   Lim, Jackie E ^b   Skol, Andrew D ^a   Abney, Mark ^a   Palmer, Abraham A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED INTERCROSS LINE; ANIMAL EXPERIMENT; ANIMAL GENETICS; ANKS1B GENE; ARTICLE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENE; GENE IDENTIFICATION; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; MALE; MOUSE; MOUSE STRAIN; MOUSE STRAIN F2; MOUSE STRAIN F34; NONHUMAN; OBESITY; PHENOTYPIC VARIATION; QUANTITATIVE TRAIT LOCUS; RAD23B GENE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STK33 GENE; WAIST CIRCUMFERENCE;

ADIPOSITY; ALLELES; ANIMALS; BODY WEIGHT; CHROMOSOME MAPPING; CROSSES, GENETIC; FEMALE; GENOME-WIDE ASSOCIATION STUDY; MALE; MICE; MICE, INBRED STRAINS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

MUS;

EID: 80054756689     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-011-9349-z     Document Type: Article

References (48)

1. H Akaike 1974 A new look at the statistical model identification IEEE Trans Autom Control 19 716 723 10.1109/TAC.1974.1100705
2. B Bennett PJ Carosone-Link L Lu EJ Chesler TE Johnson 2005 Genetics of body weight in the LXS recombinant inbred mouse strains Mamm Genome 16 764 774 16261418 10.1007/s00335-005-0002-6
3. C Bouchard 1991 Current understanding of the etiology of obesity: genetic and nongenetic factors Am J Clin Nutr 53 1561S 1565S 2031488 1:STN:280:DyaK3M3jtl2htA%3D%3D (Pubitemid 21925693)
4. GA Brockmann CS Haley U Renne SA Knott M Schwerin 1998 Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth Genetics 150 369 381 9725853 1:CAS:528:DyaK1cXmtFKgsLc%3D (Pubitemid 28415530)
5. KW Broman 2002 A model selection approach for identification of quantitative trait loci in experimental crosses J R Stat Soc B 64 641 656 10.1111/1467-9868.00354
6. LA Campfield FJ Smith 1999 The pathogenesis of obesity Bailleres Best Pract Res Clin Ednocrinol Metab 13 13 30 10.1053/beem.1999.0004 1:STN:280:DC%2BD3cvgtlCqsQ%3D%3D (Pubitemid 29454265)
7. C Chai 1956 Analysis of quantitative inheritance of body size in mice. II. Gene action and segregation Genetics 41 167 178
8. R Cheng JE Lim KE Samocha G Sokoloff M Abney AD Skol AA Palmer 2010 Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations Genetics 185 1033 1044 20439773 10.1534/genetics.110.116863 1:CAS:528:DC%2BC3cXhsFOnu7jO
9. JM Cheverud TT Vaughn LS Pletscher AC Peripato ES Adams CF Erikson KJ King-Ellison 2001 Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice Mamm Genome 12 3 12 11178736 10.1007/s003350010218 1:CAS:528:DC%2BD3MXptlGqsw%3D%3D (Pubitemid 32127962)
10. JM Cheverud HA Lawson GL Fawcett B Wang LS Pletscher AR Fox TJ Maxwell TH Ehrich JP Kenney-Hunt JB Wolf CF Semenkovich 2010 Diet-dependent genetic and genomic imprinting effects on obesity in mice Obesity (Silver Spring) 19 1 160 170 10.1038/oby.2010.141
11. DC Croteau-Chonka AF Marvelle EM Lange NR Lee LS Adair LA Lange KL Mohlke 2010 Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women Obesity (Silver Spring) 19 5 1019 1027 10.1038/oby.2010.256
12. A Darvasi M Soller 1995 Advanced intercross lines, an experimental population for fine genetic mapping Genetics 141 1199 1207 8582624 1:CAS:528:DyaK28Xht1CltLs%3D
13. TH Ehrich JP Kenney TT Vaughn LS Pletscher JM Cheverud 2003 Diet, obesity, and hyperglycemia in LG/J and SM/J mice Obes Res 11 1400 1410 14627762 10.1038/oby.2003.189 1:CAS:528:DC%2BD3sXpvFOkt7s%3D (Pubitemid 41127363)
14. TH Ehrich JP Kenney-Hunt LS Pletscher JM Cheverud 2005 Genetic variation and correlation of dietary response in an advanced intercross mouse line produced from two divergent growth lines Genet Res 85 211 222 16174340 10.1017/S0016672305007603 1:CAS:528:DC%2BD2MXnsl2lsLw%3D (Pubitemid 41264228)
15. TH Ehrich T Hrbek JP Kenney-Hunt LS Pletscher B Wang CF Semenkovich JM Cheverud 2005 Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J × SM/J murine model of obesity Diabetes 54 1863 1872 15919810 10.2337/diabetes.54.6.1863 1:CAS:528:DC%2BD2MXltVaitLg%3D (Pubitemid 40770778)
16. GL Fawcett CC Roseman JP Jarvis B Wang JB Wolf JM Cheverud 2008 Genetic architecture of adiposity and organ weight using combined generation QTL analysis Obesity 16 1861 1868 18551125 10.1038/oby.2008.300 1:CAS:528: DC%2BD1cXptFOrtbs%3D
17. GL Fawcett JP Jarvis CC Roseman B Wang JB Wolf JM Cheverud 2010 Fine-mapping of obesity-related quantitative trait loci in an F9/10 advanced intercross line Obesity 18 1383 1392 19910941 10.1038/oby.2009.411 1:CAS:528:DC%2BC3cXnvFymt7Y%3D
18. J Flint 2011 Mapping quantitative traits and strategies to find quantitative trait genes Methods 53 2 163 174 20643209 10.1016/j.ymeth.2010.07. 007 1:CAS:528:DC%2BC3MXhtlaksbc%3D
19. J Flint TFC Mackay 2009 Genetic architecture of quantitative traits in mice, flies, and humans Genome Res 19 723 733 19411597 10.1101/gr.086660.108 1:CAS:528:DC%2BD1MXlsFykur8%3D
20. H Goodale 1938 A study of the inheritance of body weight in the albino mouse by selection J Hered 29 101 112
21. A Ishikawa T Namikawa 2004 Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principle component analysis Genes Genet Syst 79 27 39 15056934 10.1266/ggs.79.27 1:CAS:528:DC%2BD2cXkslygsb4%3D (Pubitemid 38506713)
22. HA Lawson A Lee GL Fawcett B Wang LS Pletscher TJ Maxwell TH Ehrich JP Kenney-Hunt JB Wolf CF Semenkovich JM Cheverud 2011 The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model Mamm Genome 22 197 208 21210123 10.1007/s00335-010-9313-3 1:CAS:528:DC%2BC3MXjtV2ltbY%3D
23. ME Legare FS Bartlett 2nd WN Frankel 2000 A major effect QTL determined by multiple genes in epileptic EL mice Genome Res 10 42 48 10645948 1:CAS:528:DC%2BD3cXpslyquw%3D%3D (Pubitemid 30095253)
24. Levi J, Vinter S, St. Laurent R, Segal LM (2010) F as in Fat: How Obesity Threatens America's Future [online], Trust for America's Health and Robert Wood Johnson Foundation. http://healthyamericans.org/reports/obesity2010/ Obesity2010Report.pdf. Accessed 25 April 2011
25. A Lionikas R Cheng JE Lim AA Palmer DA Blizard 2010 Fine-mapping of muscle weight QTL in LG/J and SM/J intercrosses Physiol Genomics 42A 33 38 20627939 10.1152/physiolgenomics.00100.2010 1:CAS:528:DC%2BC3cXhtlGjurzF
26. RJ Loos C Bouchard 2008 FTO: the first gene contributing to common forms of human obesity Obes Rev 9 246 250 18373508 10.1111/j.1467-789X.2008.00481.x 1:CAS:528:DC%2BD1cXmsVWgtrY%3D (Pubitemid 351550693)
27. J MacArthur 1944 Genetics of body size and related characters. I. Selection of small and large races of the laboratory mouse Am Nat 78 142 157 10.1086/281181
28. TA Manolio FS Collins NJ Cox DB Goldstein LA Hindorff DJ Hunter MI McCarthy EM Ramos LR Cardon A Chakravarti JH Cho AE Guttmacher A Kong L Kruglyak E Mardis CN Rotimi M Slatkin D Valle AS Whittemore M Boehnke AG Clark EE Eichler G Gibson JL Haines TF Mackay SA McCarroll PM Visscher 2009 Finding the missing heritability of complex diseases Nature 461 747 753 19812666 10.1038/nature08494 1:CAS:528:DC%2BD1MXht1CisbrF
29. KH Morris A Ishikawa PD Keightley 1999 Quantitative trait loci for growth traits in C57BL/6J × DBA/2J mice Mamm Genome 10 225 228 10051315 10.1007/s003359900977 1:CAS:528:DyaK1MXhs1OlsLw%3D (Pubitemid 29390507)
30. R Mott CJ Talbot MG Turri AC Collins J Flint 2000 A method for fine-mapping quantitative trait loci in outbred animal stocks Proc Natl Acad Sci USA 97 12649 12654 11050180 10.1073/pnas.230304397
31. C Neuschl GA Brockmann SA Knott 2007 Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice Genet Res 89 47 59 17517159 10.1017/S001667230700852X 1:CAS:528:DC%2BD2sXlsFGrs7w%3D (Pubitemid 46844597)
32. JM Ng H Vrieling K Sugasawa MP Ooms JA Grootegoed JT Vreeburg P Visser RB Beems TG Gorgels F Hanaoka JH Hoeijmakers GT van der Horst 2002 Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B Mol Cell Biol 22 1233 1245 11809813 10.1128/MCB.22.4.1233-1245.2002 1:CAS:528:DC%2BD38XovVWquw%3D%3D (Pubitemid 34094858)
33. DL Nicolae E Gamazon W Zhang S Duan ME Dolan NJ Cox 2010 Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS PLos Genet 6 e1000888 20369019 10.1371/journal.pgen.1000888
34. Nocedal J, Wright SJ (1999) Numerical optimization. Springer, New York
35. EA Norgard HA Lawson LS Pletscher B Wang VR Brooks JB Wolf JM Cheverud 2011 Genetic factors and diet affect long-bone length in the F(34) LG, SM advanced intercross Mamm Genome 22 3-4 178 196 21170743 10.1007/s00335-010-9311- 5
36. CC Parker AA Palmer 2011 Dark matter: are mice the solution to missing heritability? Front Gene 2 32 10.3389/fgene.2011.00032
37. LL Peters RF Robledo CJ Bult GA Churchill BJ Paigen KL Svenson 2007 The mouse as a model for human biology: a resource guide for complex trait analysis Nat Rev Genet 8 58 69 17173058 10.1038/nrg2025 1:CAS:528:DC%2BD28Xhtlakt7fJ (Pubitemid 46006050)
38. PM Petkov MA Cassell EE Sargent CJ Donnelly P Robinson V Crew S Asquith RV Haar MV Wiles 2004 Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse Genomics 83 902 911 15081119 10.1016/j.ygeno.2003.11.007 1:CAS:528:DC%2BD2cXivFGnsrg%3D (Pubitemid 38469929)
39. T Rankinen A Zuberi YC Chagnon SJ Weisnagel G Argyropoulos B Walts L Perusse C Bouchard 2006 The human obesity gene map: the 2005 update Obesity (Silver Spring) 14 529 644 10.1038/oby.2006.71 (Pubitemid 46219737)
40. KE Samocha JE Lim R Cheng G Sokoloff AA Palmer 2010 Fine mapping of QTL for prepulse inhibition in LG/J and SM/J mice using F2 and advanced intercross lines Genes Brain Behav 9 759 767 20597988 10.1111/j.1601-183X.2010.00613.x 1:STN:280:DC%2BC3cbjs1ertA%3D%3D
41. Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel CI, Muller TD, Grallert H, Wichmann HE, Balkau B, Heude B, Jarvelin MR, Hartikainen AL, Levy-Marchal C, Weill J, Delplanque J, Korner A, Kiess W, Kovacs P, Rayner NW, Prokopenko I, McCarthy MI, Schafer H, Jarick I, Boeing H, Fisher E, Reinehr T, Heinrich J, Rzehak P, Berdel D, Borte M, Biebermann H, Krude H, Rosskopf D, Rimmbach C, Rief W, Fromme T, Klingenspor M, Schurmann A, Schulz N, Nothen MM, Muhleisen TW, Erbel R, Jockel KH, Moebus S, Boes T, Illig T, Froguel P, Hebebrand J, Meyre D (2010) Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in french and german study groups. PLoS Genet 6:e1000916
42. H Shao DS Sinasac LC Burrage CA Hodges PJ Supelak MR Palmert C Moreno AW Cowley Jr HJ Jacob JH Nadeau 2010 Analyzing complex traits with congenic strains Mamm Genome 21 276 286 20524000 10.1007/s00335-010-9267-5
43. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segrè AV, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpeläinen TO, Yang J, Bouatia-Naji N, Esko T, Feitosa MF, Kutalik Z, Mangino M, Raychaudhuri S, Scherag A, Smith AV, Welch R, Zhao JH, Aben KK, Absher DM, Amin N, Dixon AL, Fisher E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ, Johansson A, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers RH, Narisu N, Perry JR, Peters MJ, Preuss M, Ripatti S, Rivadeneira F, Sandholt C, Scott LJ, Timpson NJ, Tyrer JP, van Wingerden S, Watanabe RM, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper MN, Jansson JO, Lawrence RW, Pellikka N, Prokopenko I, Shi J, Thiering E, Alavere H, Alibrandi MT, Almgren P, Arnold AM, Aspelund T, Atwood LD, Balkau B, Balmforth AJ, Bennett AJ, Ben-Shlomo Y, Bergman RN, Bergmann S, Biebermann H, Blakemore AI, Boes T, Bonnycastle LL, Bornstein SR, Brown MJ, Buchanan TA, Busonero F, Campbell H, Cappuccio FP, Cavalcanti-Proença C, Chen YD, Chen CM, Chines PS, Clarke R, Coin L, Connell J, Day IN, Heijer M, Duan J, Ebrahim S, Elliott P, Elosua R, Eiriksdottir G, Erdos MR, Eriksson JG, Facheris MF, Felix SB, Fischer-Posovszky P, Folsom AR, Friedrich N, Freimer NB, Fu M, Gaget S, Gejman PV, Geus EJ, Gieger C, Gjesing AP, Goel A, Goyette P, Grallert H, Grässler J, Greenawalt DM, Groves CJ, Gudnason V, Guiducci C, Hartikainen AL, Hassanali N, Hall AS, Havulinna AS, Hayward C, Heath AC, Hengstenberg C, Hicks AA, Hinney A, Hofman A, Homuth G, Hui J, Igl W, Iribarren C, Isomaa B, Jacobs KB, Jarick I, Jewell E, John U, Jørgensen T, Jousilahti P, Jula A, Kaakinen M, Kajantie E, Kaplan LM, Kathiresan S, Kettunen J, Kinnunen L, Knowles JW, Kolcic I, König IR, Koskinen S, Kovacs P, Kuusisto J, Kraft P, Kvaløy K, Laitinen J, Lantieri O, Lanzani C, Launer LJ, Lecoeur C, Lehtimäki T, Lettre G, Liu J, Lokki ML, Lorentzon M, Luben RN, Ludwig B; MAGIC, Manunta P, Marek D, Marre M, Martin NG, McArdle WL, McCarthy A, McKnight B, Meitinger T, Melander O, Meyre D, Midthjell K, Montgomery GW, Morken MA, Morris AP, Mulic R, Ngwa JS, Nelis M, Neville MJ, Nyholt DR, O'Donnell CJ, O'Rahilly S, Ong KK, Oostra B, Paré G, Parker AN, Perola M, Pichler I, Pietiläinen KH, Platou CG, Polasek O, Pouta A, Rafelt S, Raitakari O, Rayner NW, Ridderstråle M, Rief W, Ruokonen A, Robertson NR, Rzehak P, Salomaa V, Sanders AR, Sandhu MS, Sanna S, Saramies J, Savolainen MJ, Scherag S, Schipf S, Schreiber S, Schunkert H, Silander K, Sinisalo J, Siscovick DS, Smit JH, Soranzo N, Sovio U, Stephens J, Surakka I, Swift AJ, Tammesoo ML, Tardif JC, Teder-Laving M, Teslovich TM, Thompson JR, Thomson B, Tönjes A, Tuomi T, van Meurs JB, van Ommen GJ, Vatin V, Viikari J, Visvikis-Siest S, Vitart V, Vogel CI, Voight BF, Waite LL, Wallaschofski H, Walters GB, Widen E, Wiegand S, Wild SH, Willemsen G, Witte DR, Witteman JC, Xu J, Zhang Q, Zgaga L, Ziegler A, Zitting P, Beilby JP, Farooqi IS, Hebebrand J, Huikuri HV, James AL, Kähönen M, Levinson DF, Macciardi F, Nieminen MS, Ohlsson C, Palmer LJ, Ridker PM, Stumvoll M, Beckmann JS, Boeing H, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Collins FS, Cupples LA, Smith GD, Erdmann J, Froguel P, Grönberg H, Gyllensten U, Hall P, Hansen T, Harris TB, Hattersley AT, Hayes RB, Heinrich J, Hu FB, Hveem K, Illig T, Jarvelin MR, Kaprio J, Karpe F, Khaw KT, Kiemeney LA, Krude H, Laakso M, Lawlor DA, Metspalu A, Munroe PB, Ouwehand WH, Pedersen O, Penninx BW, Peters A, Pramstaller PP, Quertermous T, Reinehr T, Rissanen A, Rudan I, Samani NJ, Schwarz PE, Shuldiner AR, Spector TD, Tuomilehto J, Uda M, Uitterlinden A, Valle TT, Wabitsch M, Waeber G, Wareham NJ, Watkins H; Procardis Consortium, Wilson JF, Wright AF, Zillikens MC, Chatterjee N, McCarroll SA, Purcell S, Schadt EE, Visscher PM, Assimes TL, Borecki IB, Deloukas P, Fox CS, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, Mohlke KL, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, van Duijn CM, Wichmann HE, Frayling TM, Thorsteinsdottir U, Abecasis GR, Barroso I, Boehnke M, Stefansson K, North KE, McCarthy MI, Hirschhorn JN, Ingelsson E, Loos RJ(2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42:937-948
44. G Stratigopoulos SL Padilla CA LeDuc E Watson AT Hattersley MI McCarthy LM Zeltser WK Chung RL Leibel 2008 Regulation of Fto/Ftm gene expression in mice and humans Am J Physiol Regul Integr Comp Physiol 294 R1185 R1196 18256137 10.1152/ajpregu.00839.2007 1:CAS:528:DC%2BD1cXkvVyksLw%3D (Pubitemid 351490637)
45. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of Anthropometric Traits Consortium (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41:25-34
46. WC Willet WH Dietz GA Colditz 1999 Guidelines for healthy weight N Engl J Med 341 427 434 10.1056/NEJM199908053410607 (Pubitemid 29362517)
47. H Yang TA Bell GA Churchill F Pardo-Manuel de Villena 2007 On the subspecific origin of the laboratory mouse Nat Genet 39 1100 1107 17660819 10.1038/ng2087 1:CAS:528:DC%2BD2sXps12gtLs%3D (Pubitemid 47340646)
48. ZB Zeng CH Kao CJ Basten 1999 Estimating the genetic architecture of quantitative traits Genet Res 74 279 289 10689805 10.1017/S0016672399004255 1:STN:280:DC%2BD3c7lsVeqtw%3D%3D (Pubitemid 30076806)