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Volumn 10, Issue 6, 2011, Pages 935-945

The effect of antibiotics on bone healing: Current evidence

Author keywords

Antibiotics; Bone healing; Mesenchymal stem cells

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN; ANTIBIOTIC AGENT; CEFAZOLIN; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; CLINDAMYCIN; CYTOKINE; GENTAMICIN; GROWTH FACTOR; LEVOFLOXACIN; NORFLOXACIN; OFLOXACIN; PEFLOXACIN; PENICILLIN DERIVATIVE; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TOBRAMYCIN; TROVAFLOXACIN; VANCOMYCIN;

EID: 80054742901     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2011.589833     Document Type: Review
Times cited : (39)

References (83)
  • 2
    • 0036674355 scopus 로고    scopus 로고
    • Behaviours and rituals in the operating theatre: A report from the hospital infection society working party on infection control in operating theatres
    • DOI 10.1053/jhin.2002.1220, PII S019567010291220X
    • Woodhead K, Taylor EW, Bannister G, et al. Behaviours and rituals in the operating theatre: a report from the Hospital Infection Society Working Party on Infection Control in Operating Theatres. J Hosp Infect 2002;51:241-55 (Pubitemid 38001874)
    • (2002) Journal of Hospital Infection , vol.51 , Issue.4 , pp. 241-255
    • Woodhead, K.1    Taylor, E.W.2    Bannister, G.3    Chesworth, T.4    Hoffman, P.5    Humphreys, H.6
  • 4
    • 48249115152 scopus 로고    scopus 로고
    • Adherence to recommendations designed to decrease intra-operative wound contamination
    • Mackain-Bremner AA, Owens K, Wylde V, et al. Adherence to recommendations designed to decrease intra-operative wound contamination. Ann R Coll Surg Engl 2008;90:412-16
    • (2008) Ann R Coll Surg Engl , vol.90 , pp. 412-16
    • MacKain-Bremner, A.A.1    Owens, K.2    Wylde, V.3
  • 5
    • 76749160373 scopus 로고    scopus 로고
    • Antibiotic prophylaxis after total joint replacements
    • Kuong EE, Ng FY, Yan CH, et al. Antibiotic prophylaxis after total joint replacements. Hong Kong Med J 2009;15:458-62
    • (2009) Hong Kong Med J , vol.15 , pp. 458-62
    • Kuong, E.E.1    Ng, F.Y.2    Yan, C.H.3
  • 6
    • 73449125538 scopus 로고    scopus 로고
    • Antibiotic prophylaxis for total joint replacement surgery: Results of a survey of Canadian orthopedic surgeons
    • de Beer J, Petruccelli D, Rotstein C, et al. Antibiotic prophylaxis for total joint replacement surgery: results of a survey of Canadian orthopedic surgeons. Can J Surg 2009;52:E229-34
    • (2009) Can J Surg , vol.52
    • De Beer, J.1    Petruccelli, D.2    Rotstein, C.3
  • 7
    • 34548041132 scopus 로고    scopus 로고
    • Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes
    • DOI 10.1016/j.biomaterials.2007.07.037, PII S014296120700556X
    • Popat KC, Eltgroth M, Latempa TJ, et al. Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes. Biomaterials 2007;28:4880-8 (Pubitemid 47285337)
    • (2007) Biomaterials , vol.28 , Issue.32 , pp. 4880-4888
    • Popat, K.C.1    Eltgroth, M.2    LaTempa, T.J.3    Grimes, C.A.4    Desai, T.A.5
  • 9
    • 0036563184 scopus 로고    scopus 로고
    • Cefuroxime-impregnated cement in primary total knee arthroplasty: A prospective, randomized study of three hundred and forty knees
    • Chiu FY, Chen CM, Lin CF, Lo WH. Cefuroxime-impregnated cement in primary total knee arthroplasty: a prospective, randomized study of three hundred and forty knees. J Bone Joint Surg Am 2002;84-A:759-62
    • (2002) J Bone Joint Surg Am , vol.84 A , pp. 759-62
    • Chiu, F.Y.1    Chen, C.M.2    Lin, C.F.3    Lo, W.H.4
  • 10
    • 0027381820 scopus 로고
    • Prognosis of total hip replacement in Sweden. Follow-up of 92,675 operations performed 1978-1990
    • Malchau H, Herberts P, Ahnfelt L. Prognosis of total hip replacement in Sweden. Follow-up of 92,675 operations performed 1978-1990. Acta Orthop Scand 1993;64:497-506 (Pubitemid 23329852)
    • (1993) Acta Orthopaedica Scandinavica , vol.64 , Issue.5 , pp. 497-506
    • Malchau, H.1    Herberts, P.2    Ahnfelt, L.3
  • 11
    • 0347601726 scopus 로고    scopus 로고
    • Antibiotic prophylaxis in total hip arthroplasty: Effects of antibiotic prophylaxis systemically and in bone cement on the revision rate of 22,170 primary hip replacements followed 0-14 years in the Norwegian Arthroplasty Register
    • DOI 10.1080/00016470310018135
    • Engesaeter LB, Lie SA, Espehaug B, et al. Antibiotic prophylaxis in total hip arthroplasty: effects of antibiotic prophylaxis systemically and in bone cement on the revision rate of 22,170 primary hip replacements followed 0-14 years in the Norwegian Arthroplasty Register. Acta Orthop Scand 2003;74:644-51 (Pubitemid 38067862)
    • (2003) Acta Orthopaedica Scandinavica , vol.74 , Issue.6 , pp. 644-651
    • Engesaeter, L.B.1    Lie, S.A.2    Espehaug, B.3    Furnes, O.4    Vollset, S.E.5    Havelin, L.I.6
  • 13
    • 33750823074 scopus 로고    scopus 로고
    • Current concepts review: Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement
    • DOI 10.2106/JBJS.E.01126
    • Jiranek WA, Hanssen AD, Greenwald AS. Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am 2006;88:2487-500 (Pubitemid 44713839)
    • (2006) Journal of Bone and Joint Surgery - Series A , vol.88 , Issue.11 , pp. 2487-2500
    • Jiranek, W.A.1    Hanssen, A.D.2    Greenwald, A.S.3
  • 15
    • 5444261483 scopus 로고    scopus 로고
    • The current status of material used for depot delivery of drugs
    • DOI 10.1097/01.blo.0000143741.92384.18
    • Nelson CL. The current status of material used for depot delivery of drugs. Clin Orthop Relat Res 2004;427:72-8 (Pubitemid 39362834)
    • (2004) Clinical Orthopaedics and Related Research , Issue.427 , pp. 72-78
    • Nelson, C.L.1
  • 16
    • 79952200718 scopus 로고    scopus 로고
    • Antibiotic-coated spacers for total hip arthroplasty infection
    • Bloomfield MR, Klika AK, Barsoum WK. Antibiotic-coated spacers for total hip arthroplasty infection. Orthopedics 2010;33:649
    • (2010) Orthopedics , vol.33 , pp. 649
    • Bloomfield, M.R.1    Klika, A.K.2    Barsoum, W.K.3
  • 18
    • 5444276690 scopus 로고    scopus 로고
    • Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections
    • DOI 10.1097/01.blo.0000143554.56897.26
    • McLaren AC. Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections. Clin Orthop Relat Res 2004;427:101-6 (Pubitemid 39362838)
    • (2004) Clinical Orthopaedics and Related Research , Issue.427 , pp. 101-106
    • McLaren, A.C.1
  • 19
    • 0031054151 scopus 로고    scopus 로고
    • In vitro evaluation of antibiotic diffusion from antibiotic-impregnated biodegradable beads and polymethylmethacrylate beads
    • Mader JT, Calhoun J, Cobos J. In vitro evaluation of antibiotic diffusion from antibiotic-impregnated biodegradable beads and polymethylmethacrylate beads. Antimicrob Agents Chemother 1997;41:415-18 (Pubitemid 27111039)
    • (1997) Antimicrobial Agents and Chemotherapy , vol.41 , Issue.2 , pp. 415-418
    • Mader, J.T.1    Calhoun, J.2    Cobos, J.3
  • 21
    • 77952287336 scopus 로고    scopus 로고
    • Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles
    • Peng KT, Chen CF, Chu IM, et al. Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles. Biomaterials 2010;31:5227-36
    • (2010) Biomaterials , vol.31 , pp. 5227-36
    • Peng, K.T.1    Chen, C.F.2    Chu, I.M.3
  • 23
    • 77955958400 scopus 로고    scopus 로고
    • Preparation, antibacterial properties and biocompatibility studies on vancomycin-poly(D,L)-lactic loaded plates
    • Tang L, Zhao C, Xiong Y, Wang A. Preparation, antibacterial properties and biocompatibility studies on vancomycin-poly(D,L)-lactic loaded plates. Int Orthop 2010;34:755-9
    • (2010) Int Orthop , vol.34 , pp. 755-9
    • Tang, L.1    Zhao, C.2    Xiong, Y.3    Wang, A.4
  • 24
    • 33846215617 scopus 로고    scopus 로고
    • Effect of therapeutic levels of doxycycline and minocycline in the proliferation and differentiation of human bone marrow osteoblastic cells
    • DOI 10.1016/j.archoralbio.2006.10.005, PII S0003996906002676
    • Gomes PS, Fernandes MH. Effect of therapeutic levels of doxycycline and minocycline in the proliferation and differentiation of human bone marrow osteoblastic cells. Arch Oral Biol 2007;52:251-9 (Pubitemid 46096435)
    • (2007) Archives of Oral Biology , vol.52 , Issue.3 , pp. 251-259
    • Gomes, P.S.1    Fernandes, M.H.2
  • 27
  • 28
    • 33750633626 scopus 로고    scopus 로고
    • Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells
    • DOI 10.1097/01.blo.0000229324.75911.c7, PII 0000308620061100000045
    • Chang Y, Goldberg VM, Caplan AI. Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells. Clin Orthop Relat Res 2006;452:242-9 (Pubitemid 44690676)
    • (2006) Clinical Orthopaedics and Related Research , Issue.452 , pp. 242-249
    • Chang, Y.1    Goldberg, V.M.2    Caplan, A.I.3
  • 29
    • 0037350503 scopus 로고    scopus 로고
    • Gentamicin may have an adverse effect on osteogenesis
    • DOI 10.1097/00005131-200303000-00010
    • Isefuku S, Joyner CJ, Simpson AH. Gentamicin may have an adverse effect on osteogenesis. J Orthop Trauma 2003;17:212-16 (Pubitemid 36395374)
    • (2003) Journal of Orthopaedic Trauma , vol.17 , Issue.3 , pp. 212-216
    • Isefuku, S.1    Joyner, C.J.2    Simpson, A.H.R.W.3
  • 30
    • 0023733135 scopus 로고
    • Effects of gentamicin and monomer on bone. An in vitro study
    • DOI 10.1016/S0883-5403(88)80011-1
    • Pedersen JG, Lund B. Effects of gentamicin and monomer on bone. An in vitro study. J Arthroplasty 1988;3:S63-8 (Pubitemid 18263002)
    • (1988) Journal of Arthroplasty , vol.3 , Issue.SUPPL.
    • Pedersen, J.G.1    Lund, B.2
  • 32
    • 0032200302 scopus 로고    scopus 로고
    • Tetracycline derivatives induce apoptosis selectively in cultured monocytes and macrophages but not in mesenchymal cells
    • Bettany JT, Wolowacz RG. Tetracycline derivatives induce apoptosis selectively in cultured monocytes and macrophages but not in mesenchymal cells. Adv Dent Res 1998;12:136-43
    • (1998) Adv Dent Res , vol.12 , pp. 136-43
    • Bettany, J.T.1    Wolowacz, R.G.2
  • 35
    • 0034266823 scopus 로고    scopus 로고
    • Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro
    • Holtom PD, Pavkovic SA, Bravos PD, et al. Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro. J Orthop Res 2000;18:721-7
    • (2000) J Orthop Res , vol.18 , pp. 721-7
    • Holtom, P.D.1    Pavkovic, S.A.2    Bravos, P.D.3
  • 36
    • 41549100057 scopus 로고    scopus 로고
    • Cell-induced response by tetracyclines on human bone marrow colonized hydroxyapatite and Bonelike
    • Gomes PS, Santos JD, Fernandes MH. Cell-induced response by tetracyclines on human bone marrow colonized hydroxyapatite and Bonelike. Acta Biomater 2008;4:630-7
    • (2008) Acta Biomater , vol.4 , pp. 630-7
    • Gomes, P.S.1    Santos, J.D.2    Fernandes, M.H.3
  • 37
    • 0034872053 scopus 로고    scopus 로고
    • Toxic effect of rifampicin on human osteoblast-like cells
    • DOI 10.1016/S0736-0266(01)00022-5, PII S0736026601000225
    • Isefuku S, Joyner CJ, Simpson AH. Toxic effect of rifampicin on human osteoblast-like cells. J Orthop Res 2001;19:950-4 (Pubitemid 32799087)
    • (2001) Journal of Orthopaedic Research , vol.19 , Issue.5 , pp. 950-954
    • Isefuku, S.1    Joyner, C.J.2    Simpson, A.H.R.W.3
  • 38
  • 39
    • 0032124582 scopus 로고    scopus 로고
    • Effect of ciprofloxacin on the proliferation of osteoblast-like MG-63 human osteosarcoma cells in vitro
    • DOI 10.1002/jor.1100160417
    • Miclau T, Edin ML, Lester GE, et al. Effect of ciprofloxacin on the proliferation of osteoblast-like MG-63 human osteosarcoma cells in vitro. J Orthop Res 1998;16:509-12 (Pubitemid 28427703)
    • (1998) Journal of Orthopaedic Research , vol.16 , Issue.4 , pp. 509-512
    • Miclau, T.1    Edin, M.L.2    Lester, G.E.3    Lindsey, R.W.4    Dahners, L.E.5
  • 40
    • 0029438582 scopus 로고
    • Bone toxicity of locally applied aminoglycosides
    • Miclau T, Edin ML, Lester GE, et al. Bone toxicity of locally applied aminoglycosides. J Orthop Trauma 1995;9:401-6
    • (1995) J Orthop Trauma , vol.9 , pp. 401-6
    • Miclau, T.1    Edin, M.L.2    Lester, G.E.3
  • 42
    • 67649933480 scopus 로고    scopus 로고
    • The effect of fluoroquinolone antibiotics on growing cartilage in the lamb model
    • Sansone JM, Wilsman NJ, Leiferman EM, et al. The effect of fluoroquinolone antibiotics on growing cartilage in the lamb model. J Pediatr Orthop 2009;29:189-95
    • (2009) J Pediatr Orthop , vol.29 , pp. 189-95
    • Sansone, J.M.1    Wilsman, N.J.2    Leiferman, E.M.3
  • 43
    • 33644699384 scopus 로고    scopus 로고
    • Stimulation of fracture healing by continuous delivery of demineralized bone matrix proteins and tobramycin
    • Galjour C, Dzugan S, Graves M, et al. Stimulation of fracture healing by continuous delivery of demineralized bone matrix proteins and tobramycin. Biomed Sci Instrum 2005;41:122-7
    • (2005) Biomed Sci Instrum , vol.41 , pp. 122-7
    • Galjour, C.1    Dzugan, S.2    Graves, M.3
  • 45
    • 20344390028 scopus 로고    scopus 로고
    • A comparison of effects of floroquinolones on fracture healing (an experimental study in rats)
    • Tuncay I, Ozbek H, Kosem M, Unal O. A comparison of effects of fluoroquinolones on fracture healing (an experimental study in rats). Ulus Travma Acil Cerrahi Derg 2005;111:17-22 (Pubitemid 40283359)
    • (2005) Ulusal Travma ve Acil Cerrahi Dergisi , vol.11 , Issue.1 , pp. 17-22
    • Tuncay, I.1    Ozbek, H.2    Kosem, M.3    Unal, O.4
  • 46
    • 0029093020 scopus 로고
    • Fluoroquinolones in paediatrics-1995
    • Dagan R. Fluoroquinolones in paediatrics-1995. Drugs 1995;49:92-9
    • (1995) Drugs , vol.49 , pp. 92-9
    • Dagan, R.1
  • 48
    • 0034453916 scopus 로고    scopus 로고
    • Clinical pharmacology of the fluoroquinolones: Studies in human dynamic/kinetic models
    • DOI 10.1086/314059
    • Schentag J.J. Clinical pharmacology of the fluoroquinolones: studies in human dynamic/kinetic models. Clin Infect Dis 2000;31:S40-4 (Pubitemid 32269608)
    • (2000) Clinical Infectious Diseases , vol.31 , Issue.SUPPL. 2
    • Schentag, J.J.1
  • 49
    • 80054740463 scopus 로고    scopus 로고
    • AHFS drug Information. American Society of Health-System Pharmacists
    • McEvoy G. AHFS drug Information. American Society of Health-System Pharmacists. ASHP; 2010
    • (2010) ASHP
    • McEvoy, G.1
  • 50
    • 0016183658 scopus 로고
    • The pharmacokinetics of amoxicillin
    • Hoffler D. The pharmacokinetics of amoxicillin. Adv Clin Pharmacol 1974;7:28-30
    • (1974) Adv Clin Pharmacol , vol.7 , pp. 28-30
    • Hoffler, D.1
  • 54
    • 0017074910 scopus 로고
    • Cefuroxime: Human pharmacokinetics
    • Foord RD. Cefuroxime: human pharmacokinetics. Antimicrob Agents Chemother 1976;9:741-7
    • (1976) Antimicrob Agents Chemother , vol.9 , pp. 741-7
    • Foord, R.D.1
  • 55
    • 0018342086 scopus 로고
    • Cefuroxime: A review of its antibacterial activity, pharmacological properties and therapeutic use
    • Brogden RN, Heel RC, Speight TM, Avery GS. Cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs 1979;17:233-66 (Pubitemid 9155179)
    • (1979) Drugs , vol.17 , Issue.4 , pp. 233-266
    • Brogden, R.N.1    Heel, R.C.2    Speight, T.M.3    Avery, G.S.4
  • 56
    • 0026573981 scopus 로고
    • In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads
    • Adams K, Couch L, Cierny G, et al. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin Orthop Relat Res 1992;278:244-52
    • (1992) Clin Orthop Relat Res , vol.278 , pp. 244-52
    • Adams, K.1    Couch, L.2    Cierny, G.3
  • 57
    • 57749102729 scopus 로고    scopus 로고
    • Measurements of in vivo intra-articular gentamicin levels from antibiotic loaded articulating spacers in revision total knee replacement
    • Mutimer J, Gillespie G, Lovering AM, Porteous AJ. Measurements of in vivo intra-articular gentamicin levels from antibiotic loaded articulating spacers in revision total knee replacement. Knee 2009;16:39-41
    • (2009) Knee , vol.16 , pp. 39-41
    • Mutimer, J.1    Gillespie, G.2    Lovering, A.M.3    Porteous, A.J.4
  • 58
    • 0018102833 scopus 로고
    • The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study
    • Wahlig H, Dingeldein E, Bergmann R, Reuss K. The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study. J Bone Joint Surg Br 1978;60:270-5 (Pubitemid 8356875)
    • (1978) Journal of Bone and Joint Surgery - Series B , vol.60 B , Issue.2 , pp. 270-275
    • Wahlig, H.1    Dingeldein, E.2    Bergmann, R.3    Reuss, K.4
  • 59
    • 11044223938 scopus 로고    scopus 로고
    • An articulated antibiotic spacer used for infected total knee arthroplasty: A comparative in vitro elution study of Simplex® and Palacos® bone cements
    • DOI 10.1016/j.orthres.2004.03.003, PII S0736026604000646
    • Stevens CM, Tetsworth KD, Calhoun JH, Mader JT. An articulated antibiotic spacer used for infected total knee arthroplasty: a comparative in vitro elution study of Simplex and Palacos bone cements. J Orthop Res 2005;23:27-33 (Pubitemid 40045073)
    • (2005) Journal of Orthopaedic Research , vol.23 , Issue.1 , pp. 27-33
    • Stevens, C.M.1    Tetsworth, K.D.2    Calhoun, J.H.3    Mader, J.T.4
  • 60
    • 0036319253 scopus 로고    scopus 로고
    • The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets
    • DOI 10.1016/S0736-0266(01)00133-4, PII S0736026601001334
    • Nelson CL, McLaren SG, Skinner RA, et al. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res 2002;20:643-7 (Pubitemid 34822981)
    • (2002) Journal of Orthopaedic Research , vol.20 , Issue.4 , pp. 643-647
    • Nelson, C.L.1    McLaren, S.G.2    Skinner, R.A.3    Smeltzer, M.S.4    Roby Thomas, J.5    Olsen, K.M.6
  • 61
    • 33746985461 scopus 로고    scopus 로고
    • High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: A study of 46 patients at an average follow-up of 107 days
    • Hsieh PH, Chang YH, Chen SH, et al. High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days. J Orthop Res 2006;24:1615-21
    • (2006) J Orthop Res , vol.24 , pp. 1615-21
    • Hsieh, P.H.1    Chang, Y.H.2    Chen, S.H.3
  • 64
    • 15944424328 scopus 로고    scopus 로고
    • Influence of the method of blending an antibiotic powder with an acrylic bone cement powder on physical, mechanical, and thermal properties of the cured cement
    • DOI 10.1016/j.biomaterials.2004.11.003, PII S0142961204009664
    • Lewis G, Janna S, Bhattaram A. Influence of the method of blending an antibiotic powder with an acrylic bone cement powder on physical, mechanical, and thermal properties of the cured cement. Biomaterials 2005;26:4317-25 (Pubitemid 40430860)
    • (2005) Biomaterials , vol.26 , Issue.20 , pp. 4317-4325
    • Lewis, G.1    Janna, S.2    Bhattaram, A.3
  • 65
    • 0030444008 scopus 로고    scopus 로고
    • Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement
    • Penner MJ, Masri BA, Duncan CP. Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement. J Arthroplasty 1996;11:939-44
    • (1996) J Arthroplasty , vol.11 , pp. 939-44
    • Penner, M.J.1    Masri, B.A.2    Duncan, C.P.3
  • 66
    • 0024204683 scopus 로고
    • Release of gentamicin from acrylic bone cement. Elution and diffusion studies
    • Baker AS, Greenham LW. Release of gentamicin from acrylic bone cement. Elution and diffusion studies. J Bone Joint Surg Am 1988;70:1551-7 (Pubitemid 19038650)
    • (1988) Journal of Bone and Joint Surgery - Series A , vol.70 , Issue.10 , pp. 1551-1557
    • Baker, A.S.1    Greenham, L.W.2
  • 67
    • 4644232266 scopus 로고    scopus 로고
    • The in vitro elution of gentamicin sulfate from a commercially available gentamicin-loaded acrylic bone cement, VersaBond™ AB
    • DOI 10.1002/jbm.b.30069
    • Lewis G, Janna S. The in vitro elution of gentamicin sulfate from a commercially available gentamicin-loaded acrylic bone cement, VersaBond AB. J Biomed Mater Res B Appl Biomater 2004;71:77-83 (Pubitemid 39299406)
    • (2004) Journal of Biomedical Materials Research - Part B Applied Biomaterials , vol.71 , Issue.1 , pp. 77-83
    • Lewis, G.1    Janna, S.2
  • 68
    • 0033013320 scopus 로고    scopus 로고
    • The in vitro elution characteristics of antibiotic-loaded CMW and Palacos-R bone cements
    • DOI 10.1016/S0883-5403(99)90128-6
    • Penner MJ, Duncan CP, Masri BA. The in vitro elution characteristics of antibiotic-loaded CMW and Palacos-R bone cements. J Arthroplasty 1999;14:209-14 (Pubitemid 29095966)
    • (1999) Journal of Arthroplasty , vol.14 , Issue.2 , pp. 209-214
    • Penner, M.J.1    Duncan, C.P.2    Masri, B.A.3
  • 70
    • 65449156489 scopus 로고    scopus 로고
    • Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo
    • Anagnostakos K, Wilmes P, Schmitt E, Kelm J. Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop 2009;80:193-7
    • (2009) Acta Orthop , vol.80 , pp. 193-7
    • Anagnostakos, K.1    Wilmes, P.2    Schmitt, E.3    Kelm, J.4
  • 71
    • 33746985461 scopus 로고    scopus 로고
    • High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: A study of 46 patients at an average follow-up of 107 days
    • Hsieh PH, Chang YH, Chen SH, et al. High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days. J Orthop Res 2006;24:1615-21
    • (2006) J Orthop Res , vol.24 , pp. 1615-21
    • Hsieh, P.H.1    Chang, Y.H.2    Chen, S.H.3
  • 74
    • 39049183312 scopus 로고    scopus 로고
    • Safeness of Simplex-tobramycin bone cement in patients with renal dysfunction undergoing total hip replacement
    • Forsythe ME, Crawford S, Sterling GJ, et al. Safeness of Simplex-tobramycin bone cement in patients with renal dysfunction undergoing total hip replacement. J Orthop Surg (Hong Kong) 2006;14:38-42
    • (2006) J Orthop Surg (Hong Kong) , vol.14 , pp. 38-42
    • Forsythe, M.E.1    Crawford, S.2    Sterling, G.J.3
  • 75
    • 70350741361 scopus 로고    scopus 로고
    • Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study
    • Crider KS, Cleves MA, Reefhuis J, et al. Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. Arch Pediatr Adolesc Med 2009;163:978-85
    • (2009) Arch Pediatr Adolesc Med , vol.163 , pp. 978-85
    • Crider, K.S.1    Cleves, M.A.2    Reefhuis, J.3
  • 76
    • 79953319215 scopus 로고    scopus 로고
    • NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: Implications for mechanism of bone formation inhibition in man
    • Pountos I, Giannoudis PV, Jones E, et al. NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man. J Cell Mol Med 2011;15:525-34
    • (2011) J Cell Mol Med , vol.15 , pp. 525-34
    • Pountos, I.1    Giannoudis, P.V.2    Jones, E.3
  • 77
    • 40649084758 scopus 로고    scopus 로고
    • Pharmacological agents and impairment of fracture healing: What is the evidence?
    • Pountos I, Georgouli T, Blokhuis TJ, et al. Pharmacological agents and impairment of fracture healing: what is the evidence? Injury 2008;39:384-94
    • (2008) Injury , vol.39 , pp. 384-94
    • Pountos, I.1    Georgouli, T.2    Blokhuis, T.J.3
  • 79
    • 33745551377 scopus 로고    scopus 로고
    • Does cement increase the risk of infection in primary total hip arthroplasty? Revision rates in 56,275 cemented and uncemented primary THAs followed for 0-16 years in the Norwegian Arthroplasty Register
    • DOI 10.1080/17453670610046253, PII P7719323458240
    • Engesaeter LB, Espehaug B, Lie SA, et al. Does cement increase the risk of infection in primary total hip arthroplasty? Revision rates in 56,275 cemented and uncemented primary THAs followed for 0-16 years in the Norwegian Arthroplasty Register. Acta Orthop 2006;77:351-8 (Pubitemid 43977388)
    • (2006) Acta Orthopaedica , vol.77 , Issue.3 , pp. 351-358
    • Engesaeter, L.1    Espehaug, B.2    Lie, S.3    Furnes, O.4    Havelin, L.5
  • 80
    • 0030738582 scopus 로고    scopus 로고
    • Antibiotic prophylaxis in total hip arthroplasty: Review of 10 905 primary cemented total hip replacements reported to the Norwegian arthroplasty register, 1987 to 1995
    • Espehaug B, Engesaeter LB, Vollset SE, et al. Antibiotic prophylaxis in total hip arthroplasty. Review of 10,905 primary cemented total hip replacements reported to the Norwegian arthroplasty register, 1987 to 1995. J Bone Joint Surg Br 1997;79:590-5 (Pubitemid 127469741)
    • (1997) Journal of Bone and Joint Surgery - Series B , vol.79 , Issue.SUPPL. 4 , pp. 590-595
    • Espehaug, B.1    Engesaeter, L.B.2    Vollset, S.E.3    Havelin, L.I.4    Langeland, N.5
  • 82
    • 78649638992 scopus 로고    scopus 로고
    • Incidence of low-grade infection in aseptic loosening of total hip arthroplasty
    • Moojen DJ, van Hellemondt G, Vogely HC, et al. Incidence of low-grade infection in aseptic loosening of total hip arthroplasty. Acta Orthop 2010; 81(6):667-73
    • (2010) Acta Orthop , vol.81 , Issue.6 , pp. 667-73
    • Moojen, D.J.1    Van Hellemondt, G.2    Vogely, H.C.3
  • 83
    • 62549143996 scopus 로고    scopus 로고
    • Cost-effectiveness of antibiotic-impregnated bone cement used in primary total hip arthroplasty
    • Cummins JS, Tomek IM, Kantor SR, et al. Cost-effectiveness of antibiotic-impregnated bone cement used in primary total hip arthroplasty. J Bone Joint Surg Am 2009;91:634-41
    • (2009) J Bone Joint Surg Am , vol.91 , pp. 634-41
    • Cummins, J.S.1    Tomek, I.M.2    Kantor, S.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.