Stimulation of fracture healing by continuous delivery of demineralized bone matrix proteins and tobramycin

Biomedical Sciences Instrumentation

Volumn 41, Issue , 2005, Pages 122-127

  Galjour, Chris ^a   Dzugan, Sergey ^a   Graves, Matt ^a   Benghuzzi, Ham ^a   Russell, George ^a   Tucci, Michelle ^a   Tsao, Audrey ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Bone Healing; Continuous Release; DBM; Demineralized Bone Matrix Proteins; Drug Delivery Systems; TCPL

Indexed keywords

ANTIBIOTICS; BONE; CERAMIC MATERIALS; COMPUTER SIMULATION; FRACTURE FIXATION; MICROORGANISMS; PROTEINS; SURGERY; X RAYS; BACTERIA; CONTROLLED DRUG DELIVERY;

BACTERIAL INFECTIONS; BONE DEFECT FILLING SURGERY; DEMINERALIZED BONE MATRIX (DBM); TOBRAMYCIN;

LIVING SYSTEMS STUDIES; FRACTURE;

ANTIBIOTIC AGENT; MATRIX PROTEIN; TOBRAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC PROPHYLAXIS; BONE DEMINERALIZATION; BONE MATRIX; BONE RADIOGRAPHY; BONE REGENERATION; CANCELLOUS BONE; CERAMICS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMUR; FEMUR FRACTURE; FRACTURE HEALING; IMPLANTATION; INFECTION; MALE; MONITORING; NONHUMAN; ORGAN WEIGHT; RANDOMIZATION; RAT; RAT STRAIN; SUSTAINED DRUG RELEASE; VASCULARIZATION; X RAY;

ANIMALS; ANTI-BACTERIAL AGENTS; BONE DEMINERALIZATION TECHNIQUE; BONE MATRIX; BONE MORPHOGENETIC PROTEINS; DRUG COMBINATIONS; DRUG IMPLANTS; FEMORAL FRACTURES; FRACTURE HEALING; MALE; OSTEITIS; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; TOBRAMYCIN; TREATMENT OUTCOME;

BONE HEALING; DEMINERALIZED BONE MATRIX PROTEINS; DRUG DELIVERY SYSTEMS;

EID: 33644699384     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (32)

1. Al Ruhaimi: Bone graft substitutes: a comparative qualitative histologic review of current osteoconductive grafting materials. Int J Oral Maxillofacial Implants. 16(1):105-114 Jan-Feb 2001.
2. Bajpai PK, Benghuzzi HA: Ceramic systems for long-term delivery of chemicals and biologicals. J Bio Mat Research 22:1245-1266, 1988.
3. Bauer TW, Smith ST: Bioactive materials in orthopaedic surgery: overview and regulatory considerations. Clin Orthop 395:11-22, 2002.
4. Behnam K, Murray SS, Whitelegge JP, Brochmann EJ: Identification of the molecular chaperone alpha B-crystallin in demineralized bone powder and osteoblast like cells. J Orthop Research 20:1190-1196, 2002.
5. Benghuzzi HA, England BG, Bajpai PK: Characterization of ceramic drug delivery devices: the effect of various temperature of incubation on the delivery of biologicals. Biomed Sci Instrum. 28:129-134, 1992.
6. Benghuzzi HA, England BG, Bajpai PK: Controlled release of hydrophilic compounds by resorbable and biodegradable ceramic drug delivery devices. Biomed Sci Instrum 28:179-182, 1992.
7. Bucholz RW: Nonallograft Osteoconductive bone graft substitutes. Clin Orthop 395:44-52, 2002.
8. Byrne RS, Deasy PB: Use of commercial porous ceramic particles for sustained drug delivery. Int J Pharm 246:61-73, 2002.
9. Clayton PR: Bone repair techniques, bone graft, and bone graft substitutes. Clin Orthop 360:71-86, 1999.
10. Clokie CM, Urist MR: Bone morphogenic protein excipients: comparative observations of poloxamer. Plast Reconstr Surg 105:628-637, 2000.
11. Conflitti J, Graves M. Russell G, Tucci M, Benghuzzi H: Plating of rat femoral shaft osteotomies: report of a technique and preliminary results. Biomed Sci Instrum 39:278-283, 2003.
12. Gepstein R, Weiss RE, Hallel T: Bridging large defects in bone by demineralized bone matrix in the form of a powder. A radiographic, histological, and radioisotope-upake study in rats. J Bone Joint Surg Am 69(7):984-992, 1987.
13. Guicheaux J, Gauthier O, Aguado E, Heymann D, Pilet P, Couillaud S, Faivre A, Daculsi G: Growth hormone-loaded macroporous calcium phosphate ceramic: in vitro biopharmaceutical characterization and preliminary in vivo study. J Biomed Mat Res. 40(4):560-566, 1998.
14. Higdon KK, Scott A, Benghuzzi H, Tucci M, Puckett A, Hughes JL: Development of a sustained delivery system as a novel technique for tissue culture. Biomed Sci Instrum 36:117-122, 2000.
15. Iwata H, Sakano S, Itoh, T, Bauer TW: Demineralized bone matrix and native bone morphogenic protein in orthopaedic surgery. Clin Orthop 395:99-109, 2002.
16. Kamakura S, Sasano Y, Shimizu T, Hatori K, Suzuki O, Kagayama M, Motegi K: Implanted octocalcium is more resorbable than B-tricalcium phosphate and hydroxyapatite. J Biomed Mat Res 59:29-34, 2002.
17. Kasten P, Luginbuhl R, van Griensven M, Barkhausen T, Krettek C, Bohner M, Bosch U: Comparison of human bone marrow stromal cells on calcium-deficient hydroxyapatite, tricalcium phosphate, and demineralized bone matrix. Biomaterials 24:2593-2603, 2003.
18. Kimakhe S, Bohic S, Larrose C, Reynaud A, Pilet P, Giumelli B, Heymann D, Daculsi G: Biological activities of sustained polymyxin B release from calcium phosphate biomaterial prepared by dynamic compaction: an in vitro study. J Biomed Mater Res 47(1):18-27, 1999.
19. Kokubo T, Kim HM, Kawashita M: Novel bioactive materials with different mechanical properties. Biomaterials 24:2161-2175, 2003.
20. Legeros RZ: Properties of osteoconductive biomaterials: Calcium Phosphates. Clin Orthop 395:81-98, 2002.
21. McKee MD, Wild LM, Schemitsch EH, Waddell JP: The use of antibiotic impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma 16:622-627, 2002.
22. Muschler GF, Midura RJ: Connective tissue progenitors: practical concepts for clinical applications. Clin Orthop 395:66-80, 2002.
23. Nijhof MW, Stallman HP, Vogely HC, Fleer A, Schouls LM, Dhert WJ, Verbeut AJ: Prevention of infection with tobramycin-containing bone cement or systemic cefazolin in an animal model. J Biomed Mat Res 52(4):709-715, 2000.
24. Regenchary SS: Bone morphogenic proteins: basic concepts. Neurosurg Focus 13:1-6, 2002.
25. Shinto Y, Uchida A, Korkusuz F, Araki N, Ono K: Calcium Hydroxyapatite ceramic used as a delivery system for antibiotics. J Bone Joint Surg Br. 74(4):600-604, 1992.
26. Tamai N, Myoui A, Tomita T, Nakase T, Tanaka J, Ochi T, Yashikawa H: Novel hydroxyapatite ceramics with an interconnective structure exhibit superior osteoconduction in vivo. J Biomed Mat Res. 59:110-117, 2002.
27. Urist MR: Bone formation by autoinduction. Science 150:893-899, 1965.
28. Urist MR, Lietze A, Dawson E: Beta-tricalcium phosphate delivery system for bone morphogenetic protein. Clin Orthop. 187:277-280, 1984.
29. Urist MR, Mikulski A, Lietze A: Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci USA 76(4):1828-1832, 1979
30. Urist MR, Strates BS: Bone formation in implants of partially and wholly demineralized bone matrix including observations on acetone-fixed intra and extracellular proteins. Clin Orthop 71:271-278, 1970.
31. Vandersteenhoven JJ, Spector M: Histological investigation of bone induction by demineralized allogenic bone matrix: a natural biomaterial for osseous reconstruction. J Biomed Mater Res 17(6):1003-1014, 1983.
32. Yoon ST, Boden SD: Osteoinductive molecules in orthopaedics: basic science and preclinical studies. Clin Orthop 395:33-43, 2002.