Elution characteristics of vancomycin and tobrarnycin combined in acrylic bone-cement

Journal of Arthroplasty

Volumn 11, Issue 8, 1996, Pages 939-944

  Penner, Murray J ^b   Masri, Bassam A ^b   Duncan, Clive P ^a  

^a VANCOUVER GENERAL HOSPITAL   (Canada)

^b NONE

Author keywords

Antibiotic; Bone cement; Elution; Tobramycin; Vancomycin

Indexed keywords

ACRYLIC CEMENT; TOBRAMYCIN; TOBRAMYCIN SULFATE; VANCOMYCIN;

ANTIBIOTIC THERAPY; ARTICLE; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; DRUG RELEASE; IMMUNOASSAY;

ANTI-BACTERIAL AGENTS; BONE CEMENTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG THERAPY, COMBINATION; METHYLMETHACRYLATES; TOBRAMYCIN; VANCOMYCIN;

EID: 0030444008     PISSN: 08835403     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0883-5403(96)80135-5     Document Type: Article

References (20)

1. Duncan CP, Masri BA: Antibiotic depots. J Bone Joint Surg 75B:349, 1993
2. Duncan CP, Masri BA: The role of antibiotic-loaded cement in the treatment of an infection after a hip replacement. J Bone Joint Surg 76A:1742, 1994
3. Mackey D, Varlet A et al: Antibiotic loaded plaster of Paris pellets: an in vitro study of a possible method of local antibiotic therapy in bone infection. Clin Orthop 167:263, 1982
4. Bajpai PK, Benghuzzi HA: Ceramic systems for long-term delivery of chemicals and biologicals. J Biomed Mater Res 22:1245, 1988
5. Lawson I, Duncan CP, Beauchamp CP, et al: The elution characteristics of tobramycin from Silastic as compared to Simplex-P® and Palacos-R® acrylic cement. Orthop Trans 16:102, 1992
6. Buchholz HW, Engelbrecht H: Über die Depotwirkung einiger Antibiotica bei Vermischung mit dem Kunstharz Palacos®. Chirurg 41:511, 1970
7. Buchholz HW, Engelbrecht H, Rottger J, Siegel A: Erkenntnisse nach Wechsel von über 400 infizierten-Huftendoprothesen. Orthop Praxis 12:1117, 1977
8. Josefsson G, Lindberg L, Wiklander B: Systemic antibiotics and gentamicin-containing bone cement in the prophylaxis of infections in total hip arthroplasty. Clin Orthop 159:194, 1981
9. Buchholz HW, Elson RA, Heinert K: Antibiotic-loaded acrylic cement: current concepts. Clin Orthop 190:96, 1984
10. Murray WR: Use of antibiotic-containing bone cement. Clin Orthop 190:89, 1984
11. Buchholz HW, Elson RA, Engelbrecht E et al: Management of deep infection of total hip replacement. J Bone Joint Surg 63B:342, 1981
12. Duncan CP, Beauchamp CP: The antibiotic-loaded hip replacement: a valuable tool in the management of the complex infected total hip arthroplasty. J Bone Joint Surg 73B(suppl. II): 115, 1991
13. Duncan CP, Beauchamp CP: Total hip replacement for the management of chronic infection. J Bone Joint Surg 74B(suppl. III):275, 1992
14. Duncan CP, Beauchamp CP: A temporary antibiotic-loaded joint replacement system for management of complex infections. Orthop Clin North Am 24:751, 1993
15. Garvin KL, Fitzgerald RH, Salvati EA et al: Reconstruction of the infected total hip and knee arthroplasty with gentamicin-impregnated Palacos® bone cement. Instr Course Lect 42:293, 1993
16. Seligson D, Henry SL: Treatment of compound fractures. Am J Surg 161:693, 1991
17. Calhoun JH, Henry SL, Anger DM et al: The treatment of infected nonunions with gentamicin-polymethylmethacrylate antibiotic beads. Clin Orthop 295:23, 1993
18. Hedström S, Lidgren L, Törholm C et al: Antibiotic containing bone cement beads in the treatment of deep muscle and skeletal infections. Acta Orthop Scand 51:863, 1980
19. Majid SA, Lindberg LT, Gunterberg B, Siddiki MS: Gentamicin-PMMA beads in the treatment of chronic osteomyelitis. Acta Orthop Scand 56:265, 1985
20. Lawson KJ, Marks KE, Brems J, Rehm S: Vancomycin vs tobramycin elution from polymethylmethacrylate: an in vitro study. Orthopedics 13:521, 1990