Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles

Biomaterials

Volumn 31, Issue 19, 2010, Pages 5227-5236

  Peng, Kuo Ti ^a,d   Chen, Chin Fu ^b,c   Chu, I Ming ^b   Li, Yu Min ^b   Hsu, Wei Hsiu ^a,d   Hsu, Robert Wen Wei ^a,d   Chang, Pey Jium ^a,d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^d CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Biodegradable; Drug delivery; Hydrogel; Infection; Nanoparticle; Sol gel techniques

Indexed keywords

ANTIBIOTIC TREATMENT; BACTERIAL INFECTIONS; BIODEGRADABLE; BIODEGRADABLE HYDROGELS; BONE INFECTION; BONE LOSS; CRITICAL MICELLE CONCENTRATION (CMC); DEGRADATION RATE; DRUG DELIVERY SYSTEM; IMMUNOBLOTTING ANALYSIS; IN-SITU-GELLING; IN-VITRO; INFECTION; INFLAMMATORY RESPONSE; MONOMETHYL ETHERS; POLY(LACTIC-CO-GLYCOLIC ACID); SIDE EFFECT; SOFT TISSUE; SOL-GEL TECHNIQUE; SOL-GEL TRANSITIONS; SUSTAINED RELEASE; TARGET TISSUES; TEICOPLANIN; THERAPEUTIC STRATEGY; THERMO SENSITIVE; THERMO-SENSITIVE HYDROGEL;

ANTIBIOTICS; BONE; BONE CEMENT; CRITICAL MICELLE CONCENTRATION; DEGRADATION; DRUG DELIVERY; DRUG INTERACTIONS; ETHERS; ETHYLENE; ETHYLENE GLYCOL; GELS; MICELLES; MOTION PICTURE EXPERTS GROUP STANDARDS; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SOL-GEL PROCESS; SOL-GELS; SOLS;

HYDROGELS;

NANOPARTICLE; POLY(ETHYLENE GLYCOL) MONOMETHYL ETHER; POLYGLACTIN; POLYMER; TEICOPLANIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DEGRADATION KINETICS; ENCAPSULATION; HISTOPATHOLOGY; HYDROGEL; IMMUNOBLOTTING; NANOPHARMACEUTICS; NONHUMAN; OSTEOMYELITIS; PARTICLE SIZE; PHASE TRANSITION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; SUSTAINED DRUG RELEASE; TRANSITION TEMPERATURE; VISCOSITY;

ABSORBABLE IMPLANTS; ANIMALS; DELAYED-ACTION PREPARATIONS; HOT TEMPERATURE; HYDROGEL; NANOPARTICLES; OSTEOMYELITIS; RABBITS; TEICOPLANIN; TREATMENT OUTCOME;

BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS;

EID: 77952287336     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.03.027     Document Type: Article

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