Preparation, antibacterial properties and biocompatibility studies on vancomycin-poly(D,L)-lactic loaded plates

International Orthopaedics

Volumn 34, Issue 5, 2010, Pages 755-759

  Tang, LiangHua ^a   Zhao, ChangHong ^b   Xiong, Yan ^a   Wang, AiMin ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Bioengineering College   (China)

Author keywords

[No Author keywords available]

Indexed keywords

POLY DEXTRO LEVO LACTIC ACID; POLYMER; UNCLASSIFIED DRUG; VANCOMYCIN; ALLOY; ANTIINFECTIVE AGENT; BIOMATERIAL; TITANIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIOSTASIS; BIOCOMPATIBILITY; BONE PLATE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG DELIVERY SYSTEM; FEMALE; FIBROBLAST; GUINEA PIG; IN VITRO STUDY; INFECTION PREVENTION; MALE; MATERIAL COATING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SKIN SENSITIZATION; STAPHYLOCOCCUS AUREUS; TOXICITY TESTING; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECT; HEMOLYSIS; MICROBIOLOGICAL EXAMINATION;

ALLOYS; ANIMALS; ANTI-BACTERIAL AGENTS; BONE PLATES; CELL LINE; COATED MATERIALS, BIOCOMPATIBLE; FEMALE; FIBROBLASTS; GUINEA PIGS; HEMOLYSIS; MALE; MICE; MICROBIAL SENSITIVITY TESTS; RABBITS; RATS; STAPHYLOCOCCUS AUREUS; TITANIUM; TOXICITY TESTS; VANCOMYCIN;

EID: 77955958400     PISSN: 03412695     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00264-009-0808-z     Document Type: Article

References (19)

1. Harris LG, Richards RG (2006) Staphylococci and implant surfaces: A review. Injury 37(suppl 2):S3-S14
2. Maurer DJ, Merkow RL, Gustilo RB (1989) Infection after intramedullary nailing of severe open tibial fractures initially treated with external fixation. J Bone Joint Surg Am 71(6):835-838
3. Schmidmaier G, Wildemann B, Stemberger A et al (2001) Biodegradable poly (D, L-lactide) coating of implants for continuous release of growth factors. J Biomed Mater Res, Applied Biomat 58(4):449-455
4. Schmidmaier G, Wildemann B, Bail H et al (2001) Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-ß1) from a biodegradable poly(D, Llactide) coating of osteosynthetic implants accelerates fracture healing in rats. Bone 28(4):341-350
5. Hutmacher D, Hurzeler MB, Schliephake H (1996) A review of material properties of biodegradable and bioresorbable polymers and devices for GTR and GBR applications. Int J Oral Maxillofac Implants 11(5):667-678
6. Kulkarni RK, Moore EG, Hegyeli AF et al (1971) Biodegradable poly(lactic acid) polymers. J Biomed Mater Res 5(3):169-181
7. Kulkarni RK, Pani KC, Neuman C et al (1966) Polylactic acid for surgical implants. Arch Surg 93(5):839-843
8. Barth E, Myrvik QM, Wagner W et al (1989) In vitro and in vivo comparative colonization of Staphylococcus aureus and Staphylococcus epidermidis on orthopaedic implant materials. Biomaterials 10(5):325-328
9. Von Eiff C, Proctor RA, Peters G (2001) Coagulase-negative staphylococci. Pathogens have major role in nosocomial infections. Postgrad Med 110(4):63-76
10. Petty W, Spanier S, Shuster JJ et al (1985) The influence of skeletal implants on incidence of infection. Experiments in a canine model. J Bone Joint Surg Am 67(8):1236-1244
11. Gollwitzer H, Ibrahim K, Meyer H et al (2003) Antibacterial poly (D, L-lactic acid) coating of medical implants using a biodegradable drug delivery technology. JAC 51(3):585-591
12. Acar JF, Goldstein GW (1991) Antibiotics in laboratory medicine, 3rd edn. Williams, Wilkins, Baltimore, USA, pp 17-52
13. ISO (2006) ISO 10993-4:2002/Amd 1:2006. Biological evaluation of medical devices - part 4: Selection of tests for interactions with blood. International Organization for Standardization, Geneva, Switzerland
14. ISO (1999) ISO 10993-5:1999. Biological evaluation of medical devices - part 5: Tests for in vitro cytotoxicity. International Organization for Standardization, Geneva, Switzerland
15. ISO (2006) ISO 10993-10:2002/Amd 1:2006. Biological evaluation of medical devices - part 10: Tests for irritation and delayed-type hypersensitivity. International Organization for Standardization, Geneva, Switzerland
16. ISO (2006) ISO 10993-11:2006. Biological evaluation of medical devices - part 11: Tests for systemic toxicity. International Organization for Standardization, Geneva, Switzerland
17. Schmidmaier G, Lucke M, Wildemann B et al (2006) Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: A review. Injury 37(suppl 2):S105-S112
18. Montali A (2006) Antibacterial coating systems. Injury 37(Suppl 2):S81-S86
19. Hudetz D, UrsicHudetz S, Harris LG et al (2008) Weak effect of metal type and ica genes on staphylococcal infection of titanium and stainless steel implants. Clin Microbiol Infect 14 (12):1135-1145