Gentamicin negatively influenced osteogenic function in vitro

International Orthopaedics

Volumn 31, Issue 2, 2007, Pages 223-228

  Ince, Akif ^a,b,c   Schütze, Norbert ^a   Karl, Nadja ^a   Löhr, Jochen F ^b   Eulert, Jochen ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b ENDO Klinik   (Germany)

^c NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; GENTAMICIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; CELL LINE; CELL SURVIVAL; GENE EXPRESSION; GENTAMICINS; HUMANS; OSTEOGENESIS; POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 34248357157     PISSN: 03412695     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00264-006-0144-5     Document Type: Article

References (25)

1. Beardmore AA, Brooks DE, Wenke JC, Thomas DB (2005) Effectiveness of local antibiotic delivery with an osteoinductive and osteoconductive bone-graft substitute. J Bone Joint Surg Am 87:107-112
2. Blau HM, Chiu CP, Webster C (1983) Cytoplasmic activation of human nuclear genes in stable heterocaryons. Cell 32:1171-1180
3. Boyan BD, Schwartz Z, Bonewald LF, Swain LD (1989) Localization of 1,25-(OH)2D3-responsive alkaline phosphatase in osteoblast-like cells (ROS 17/2.8, MG 63, and MC 3T3) and growth cartilage cells in culture. J Biol Chem 264:11879-11886
4. Campbell AA, Song L, Li XS, Nelson BJ, Bottoni C, Brooks DE, DeJong ES (2000) Development, characterization, and anti-microbial efficacy of hydroxyapatite-chlorhexidine coatings produced by surface-induced mineralization. J Biomed Mater Res 53:400-407
5. Celil AB, Hollinger JO, Campbell PG (2005) Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling. J Cell Biochem 95:518-528
6. Darouiche RO, Farmer J, Chaput C, Mansouri M, Saleh G, Landon GC (1998) Anti-infective efficacy of antiseptic-coated intramedullary nails. J Bone Joint Surg Am 80:1336-1340
7. DeJong ES, DeBerardino TM, Brooks DE, Nelson BJ, Campbell AA, Bottoni CR, Pusateri AE, Walton RS, Guymon CH, McManus AT (2001) Antimicrobial efficacy of external fixator pins coated with a lipid stabilized hydroxyapatite/ chlorhexidine complex to prevent pin tract infection in a goat model. J Trauma 50:1008-1014
8. Hendrich C, Noth U, Stahl U, Merklein F, Rader CP, Schutze N, Thull R, Tuan RS, Eulert J (2002) Testing of skeletal implant surfaces with human fetal osteoblasts. Clin Orthop 394:278-289
9. Huddleston PM, Steckelberg JM, Hanssen AD, Rouse MS, Bolander ME, Patel R (2000) Ciprofloxacin inhibition of experimental fracture healing. J Bone Joint Surg Am 82:161-173
10. Ince A, Seemann K, Frommelt L, Katzer A, Lohr JF (2004) One-stage revision of shoulder arthroplasty in the case of periprosthetic infection (in German). Z Orthop Ihre Grenzgeb 142:611-617
11. Isefuku S, Joyner CJ, Simpson AH (2003) Gentamicin may have an adverse effect on osteogenesis. J Orthop Trauma 17:212-216
12. Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K (1996) A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Biol Pharm Bull 19:1518-1520
13. Jadlowiec J, Koch H, Zhang X, Campbell PG, Seyedain M, Sfeir C (2004) Phosphophoryn regulates the gene expression and differentiation of NIH3T3, MC3T3-E1, and human mesenchymal stem cells via the integrin/MAPK signaling pathway. J Biol Chem 279:53323-53330
14. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T (1994) Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127:1755-1766
15. Keating JF, Blachut PA, O'Brien PJ, Meek RN, Broekhuyse H (1996) Reamed nailing of open tibial fractures: does the antibiotic bead pouch reduce the deep infection rate? J Orthop Trauma 10:298-303
16. McKee MD, Wild LM, Schemitsch EH, Waddell JP (2002) The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma 16:622-627
17. Miclau T, Edin ML, Lester GE, Lindsey RW, Dahners LE (1998) Effect of ciprofloxacin on the proliferation of osteoblast-like MG-63 human osteosarcoma cells in vitro. J Orthop Res 16:509-512
18. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29
19. Pedersen JG, Lund B (1988) Effects of gentamicin and monomer on bone. An in vitro study. J Arthroplasty 3(Suppl):S63-S68
20. Perry AC, Prpa B, Rouse MS, Piper KE, Hanssen AD, Steckelberg JM, Patel R (2003) Levofloxacin and trovafloxacin inhibition of experimental fracture-healing. Clin Orthop 414:95-100
21. Sakano S, Murata Y, Miura T, Iwata H, Sato K, Matsui N, Seo H (1993) Collagen and alkaline phosphatase gene expression during bone morphogenetic protein (BMP)-induced cartilage and bone differentiation. Clin Orthop Relat Res 292:337-344
22. Steinbrink K, Frommelt L (1995) Treatment of periprosthetic infection of the hip using one-stage exchange surgery (in German). Orthopade 24:335-343
23. Sundin DP, Sandoval R, Molitoris BA (2001) Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking. J Am Soc Nephrol 12:114-123
24. Wahlig H, Dingeldein E, Buchholz HW, Buchholz M, Bachmann F (1984) Pharmacokinetic study of gentamicin-loaded cement in total hip replacements. Comparative effects of varying dosage. J Bone Joint Surg Br 66:175-179
25. Yaffe D, Saxel O (1977) Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature 270:725-727