Aryltriflates as a neglected moiety in medicinal chemistry: A case study from a lead optimization of CXCL8 inhibitors

ACS Medicinal Chemistry Letters

Volumn 2, Issue 10, 2011, Pages 768-773

  Moriconi, Alessio ^a   Bigogno, Chiara ^b   Bianchini, Gianluca ^a   Caligiuri, Antonio ^b   Resconi, Anna ^b   Dondio, Massimo G ^b   D'Anniballe, Gaetano ^a   Allegretti, Marcello ^a  

^a Research Center   (Italy)

^b NiKem Research   (Italy)

Author keywords

Aryltriflate; chemokine; CXCR1; CXCR2; drug profiling; dual noncompetitive inhibitor

Indexed keywords

2 [(4' TRIFLUOROMETHANESULPHONYLOXY)PHENYL] N METHANESULFONYL PROPIONAMIDE; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; TRIFLUOROMETHANESULFONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; NONHUMAN; PH; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 80054718887     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2001533     Document Type: Article

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