Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2

Journal of Medicinal Chemistry

Volumn 50, Issue 17, 2007, Pages 3984-4002

  Moriconi, Alessio ^a   Cesta, Maria Candida ^a   Cervellera, Maria Neve ^a   Aramini, Andrea ^a   Coniglio, Silvia ^a   Colagioia, Sandro ^a   Beccari, Andrea Rosario ^a   Bizzarri, Cinzia ^a   Cavicchia, Michela Rita ^a   Locati, Massimo ^b,c   Galliera, Emanuela ^b   Di Benedetto, Paola ^a   Vigilante, Paolo ^a   Bertini, Riccardo ^a   Allegretti, Marcello ^a  

^a Research Centre   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; 4 [1 METHYL 2 OXO 2 [[4 (TRIFLUOROMETHYL) 1,3 THIAZOL 2 YL]AMINO]ETHYL]PHENYLTRIFLUOROMETHANESULFONIC ACID; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CXCL1 CHEMOKINE; INTERLEUKIN 8; INTERLEUKIN 8 ANTIBODY; N (2 CHLORO 3 FLUOROPHENYL) N' [4 CHLORO 2 HYDROXY 3 (PIPERAZIN 1 YLSULFONYL)PHENYL]UREA; REPARIXIN; SB 656933; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; INFLAMMATION; ISCHEMIA; MOLECULAR WEIGHT; NEUTROPHIL; ORGAN TRANSPLANTATION; REPERFUSION INJURY; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMOTAXIS, LEUKOCYTE; DINOPROSTONE; HUMANS; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; MACROPHAGES, PERITONEAL; MESYLATES; MICE; MODELS, MOLECULAR; MUTATION; PHENYLPROPIONATES; PROPIONIC ACIDS; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548133600     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061469t     Document Type: Article

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