Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs)

Journal of Medicinal Chemistry

Volumn 53, Issue 8, 2010, Pages 3320-3329

  Kieser, Karen J ^a,b   Kim, Dong Wook ^a   Carlson, Kathryn E ^a   Katzenellenbogen, Benita S ^b   Katzenellenbogen, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,2 DIPHENYL 1 BUTENYL)CINNAMIC ACID; 4 (1,2 DIPHENYL 1 BUTENYL)CINNAMIC ACID DERIVATIVE; ACRYLIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; BICYCLO[3.3.1]NONANE DERIVATIVE; CARBONATE DEHYDRATASE XII; CARBOXYL GROUP; CYCLOFENIL; CYCLOFENIL DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ETHYLENE DERIVATIVE; FULVESTRANT; GW 7604; MESSENGER RNA; PROGESTERONE RECEPTOR; PROTEIN PS2; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TRIARYLETHYLENE ACRYLIC ACID; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PHARMACOPHORE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ACRYLATES; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BICYCLO COMPOUNDS; BINDING, COMPETITIVE; BREAST NEOPLASMS; CARBONIC ANHYDRASES; CELL LINE, TUMOR; CYCLOFENIL; DOWN-REGULATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; LIGANDS; MICROFILAMENT PROTEINS; NEUROPEPTIDES; NUCLEAR PROTEINS; RADIOLIGAND ASSAY; RECEPTORS, PROGESTERONE; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 77951122039     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100047k     Document Type: Article

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